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公开(公告)号：US20080242699A1
公开(公告)日：2008-10-02
申请号：US12019799
申请日：2008-01-25
IPC分类号： A61K31/472 , C07D217/24 , A61P25/28
CPC分类号： C07D217/24 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The invention relates to 6-cyclohexylamine-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I′) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及式（I）的6-环己胺取代的异喹啉酮衍生物或式（I'）的异喹啉衍生物，其用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的磷酸化相关的疾病 的肌球蛋白轻链磷酸酶，以及含有这些化合物的组合物。
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公开(公告)号：US20090088429A1
公开(公告)日：2009-04-02
申请号：US11961193
申请日：2007-12-20
申请人： Oliver PLETTENBURG , Armin HOFMEISTER , Dieter KADEREIT , Stefan PEUKERT , Sven RUF , Kurt RITTER , Matthias LOEHN , Yuri IVASHCHENKO , Peter MONECKE , Matthias DREYER , Aimo KANNT
发明人： Oliver PLETTENBURG , Armin HOFMEISTER , Dieter KADEREIT , Stefan PEUKERT , Sven RUF , Kurt RITTER , Matthias LOEHN , Yuri IVASHCHENKO , Peter MONECKE , Matthias DREYER , Aimo KANNT
IPC分类号： A61K31/4725 , C07D401/12 , A61K31/506 , A61K31/496 , A61K31/5377 , A61P35/00 , A61P9/10 , A61P19/10 , A61P25/28
CPC分类号： C07D405/14 , C07D401/12 , C07D401/14 , C07D409/14
摘要： The invention relates to 6-piperidinyl-substituted isoquinoline derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-哌啶基取代的异喹啉衍生物， 化合物。
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公开(公告)号：US20100081671A1
公开(公告)日：2010-04-01
申请号：US12487386
申请日：2009-06-18
申请人： Oliver PLETTENBURG , Armin HOFMEISTER , Dieter KADEREIT , Stefan PEUKERT , Sven RUF , Matthias LÖHN , Peter MONECKE , Alexander SCHIFFER , Aimo KANNT , Markus KOHLMANN
发明人： Oliver PLETTENBURG , Armin HOFMEISTER , Dieter KADEREIT , Stefan PEUKERT , Sven RUF , Matthias LÖHN , Peter MONECKE , Alexander SCHIFFER , Aimo KANNT , Markus KOHLMANN
IPC分类号： A61K31/497 , C07D217/00 , A61K31/47 , A61P9/00 , A61K31/4725 , C07D401/12
CPC分类号： C07D217/24 , C07D401/04 , C07D401/12 , C07D401/14
摘要： The invention relates to 6-substituted isoquinoline derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代的异喹啉衍生物和含有这些化合物的组合物。
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公开(公告)号：US20100056518A1
公开(公告)日：2010-03-04
申请号：US12487479
申请日：2009-06-18
申请人： Oliver PLETTENBURG , Armin HOFMEISTER , Katrin LORENZ , Joachim BRENDEL , Matthias Löhn , John Weston
发明人： Oliver PLETTENBURG , Armin HOFMEISTER , Katrin LORENZ , Joachim BRENDEL , Matthias Löhn , John Weston
IPC分类号： A61K31/5377 , C07D217/22 , A61K31/47 , C07D413/02 , C07D403/02 , A61K31/496 , A61P9/00 , A61P25/00 , A61P37/00 , A61P3/00
CPC分类号： C07D217/24 , C07D401/12
摘要： The invention relates to 6-substituted isoquinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代的异喹诺酮衍生物和含有这些化合物的组合物。
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5.发明申请Substituted isoquinoline and isoquinolinone derivatives as inhibitors of RHO-Kinase 有权取代的异喹啉和异喹啉酮衍生物作为RHO-激酶的抑制剂公开(公告)号：US20100063025A1
公开(公告)日：2010-03-11
申请号：US12487403
申请日：2009-06-18
IPC分类号： A61K31/4725 , C07D401/12 , C07D401/14 , A61K31/55 , A61P9/12 , A61P11/00 , A61P9/00 , A61P9/10 , A61P25/00 , A61P1/16 , A61P3/10 , A61P3/00 , A61P35/00
CPC分类号： C07D401/12 , C07D401/14
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物， 化合物。
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公开(公告)号：US20100105650A1
公开(公告)日：2010-04-29
申请号：US12487455
申请日：2009-06-18
IPC分类号： A61K31/4725 , C07D401/12 , C07D401/14 , A61K31/55 , A61P9/12 , A61P27/02 , A61P9/00
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及可用于治疗和/或预防与肌球蛋白轻链磷酸酶的Rho-激酶和/或Rho-激酶介导的磷酸化有关的疾病的式（I）的6-取代异喹啉和异诺酮酮衍生物， 化合物。
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7.发明申请N-Substituted (Benzoimidazol-2-yl)phenylamines, Processes for Their Preparation, Their Use as a Medicament or Diagnostic Aid, and a Medicament Comprising Them 失效N-取代的（苯并咪唑-2-基）苯胺，其制备方法，用作药物或诊断辅助剂，以及包括它们的药物公开(公告)号：US20100168196A1
公开(公告)日：2010-07-01
申请号：US12722634
申请日：2010-03-12
申请人： Uwe HEINELT , Hans-Jochen LANG , Armin HOFMEISTER , Klaus WIRTH , Martin HUG
发明人： Uwe HEINELT , Hans-Jochen LANG , Armin HOFMEISTER , Klaus WIRTH , Martin HUG
IPC分类号： A61K31/4184 , C07D235/30 , A61P11/00 , A61P13/12 , A61P1/00 , A61P9/12 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/18 , A61P9/10 , A61P7/02 , A61P1/16 , A61P33/00 , A61P33/02 , A61P33/06
CPC分类号： C07D235/30
摘要： This invention is directed to the compound of formula (I), compositions containing said compounds to inhibit the sodium-proton exchanger of subtype 3 (NHE3) which are useful in the prevention or treatment of various disorders in a patient suffering from a disease state, such as, renal disorders including acute or chronic renal failure, disorders of biliary function and for respiratory disorders such as snoring or sleep apnea or for stroke.
摘要翻译： 本发明涉及式（I）化合物，含有抑制亚型3（NHE3）的钠 - 质子交换剂的所述化合物的组合物，其可用于预防或治疗患有疾病状态的患者中的各种疾病， 例如包括急性或慢性肾衰竭，胆汁功能障碍和呼吸系统疾病如打鼾或睡眠呼吸暂停或中风的肾脏疾病。
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8.发明申请N-Substituted (Benzoimidazol-2-yl)phenylamines, Processes for Their Preparation, Their Use as a Medicament or Diagnostic Aid, and a Medicament Comprising Them 审中-公开N-取代的（苯并咪唑-2-基）苯胺，其制备方法，用作药物或诊断辅助剂，以及包括它们的药物公开(公告)号：US20080167359A1
公开(公告)日：2008-07-10
申请号：US12027033
申请日：2008-02-06
申请人： Uwe HEINELT , Hans-Jochen LANG , Armin HOFMEISTER , Klaus WIRTH , Martin HUG
发明人： Uwe HEINELT , Hans-Jochen LANG , Armin HOFMEISTER , Klaus WIRTH , Martin HUG
IPC分类号： A61K31/4184 , C07D235/04 , A61P11/00 , A61P13/12 , A61P9/00 , A61P25/00 , A61P3/00 , A61P33/00
CPC分类号： C07D235/30
摘要： This invention is directed to the compound of formula (I), compositions containing said compounds to inhibit the sodium-proton exchanger of subtype 3 (NHE3) which are useful in the prevention or treatment of various disorders in a patient suffering from a disease state, such as, renal disorders including acute or chronic renal failure, disorders of biliary function and for respiratory disorders such as snoring or sleep apnea or for stroke.
摘要翻译： 本发明涉及式（I）化合物，含有抑制亚型3（NHE3）的钠 - 质子交换剂的所述化合物的组合物，其可用于预防或治疗患有疾病状态的患者中的各种疾病， 例如包括急性或慢性肾衰竭，胆汁功能障碍和呼吸系统疾病如打鼾或睡眠呼吸暂停或中风的肾脏疾病。
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9.发明申请SUBSTITUTED TETRAHYDRO-2H-ISOQUINOLIN-1-ONE DERIVATIVES, AND METHODS FOR THE PRODUCTION AND USE THEREOF 审中-公开取代的四氢-2H-异喹啉-1-酮衍生物及其生产和使用方法公开(公告)号：US20110021462A1
公开(公告)日：2011-01-27
申请号：US12850328
申请日：2010-08-04
IPC分类号： A61K31/69 , A61K31/472 , A61K31/4725 , A61P9/10 , A61P19/02 , A61P9/00 , A61P25/28 , A61P27/02 , A61P43/00 , A61P25/00 , A61P35/00 , A61P3/10 , A61P21/00
CPC分类号： C07D413/14 , C07D217/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/14
摘要： This invention relates to compounds according to the general formula (I), where the definitions of the substituents R1, R2, Ar and X are as specified in the description, and to their physiologically tolerated salts, methods for the preparation of these compounds and their use as medicaments. These compounds are poly(ADP-ribose) polymerase (PARP) inhibitors.
摘要翻译： 本发明涉及根据通式（I）的化合物，其中取代基R 1，R 2，Ar和X的定义如说明书中所述，及其生理上可耐受的盐，制备这些化合物的方法及其制备方法 用作药物。 这些化合物是聚（ADP-核糖）聚合酶（PARP）抑制剂。
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10.发明申请SUBSTITUTED TETRAHYDROISOCHINOLINES AS MMP INHIBITORS, RELATED PRODUCTION METHOD AND USE AS MEDICINE 有权作为基质金属蛋白酶抑制剂的相关生产方法和作为药物使用的取代的四氢吲哚公开(公告)号：US20080090821A1
公开(公告)日：2008-04-17
申请号：US11862818
申请日：2007-09-27
IPC分类号： A61K31/472 , A61K31/496 , A61K31/5377 , A61P19/00 , A61P29/00 , A61P35/00 , A61P9/00 , C07D401/02 , C07D413/02
CPC分类号： C07D217/26 , C07D403/12
摘要： The present invention is directed to a compound of formula (1), wherein R1, R2, R3, R4, A, L and n are as defined herein, its pharmaceutical composition, preparation and uses as a MMP inhibitor.
摘要翻译： 本发明涉及式（1）的化合物，其中R 1，R 2，R 3，R 4 A，L和n如本文所定义，其药物组合物，制剂和用作MMP抑制剂。
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