Process for the enzymatic synthesis of pyroglutamic esters
    10.
    发明申请
    Process for the enzymatic synthesis of pyroglutamic esters 审中-公开
    酶原合成焦谷氨酸酯的方法

    公开(公告)号:US20060074259A1

    公开(公告)日:2006-04-06

    申请号:US11240933

    申请日:2005-09-30

    IPC分类号: C07C229/00

    摘要: A process for the preparation of compounds according to the general formula (I), in which R is a hydrocarbon radical of an alcohol, wherein one or more alcohols of the general formula (II) R—OH  (II) in which R is as defined above, are esterified and/or transesterified without using significant amounts of solvents, preferably without solvents, preferably under reduced pressure at temperatures below 100° C. in the presence of enzymes from the class of hydrolases with a compound according to the general formula (III), in which R1 is either hydrogen or a linear or branched alkyl or alkenyl group having 1 to 3 carbon atoms is provided.

    摘要翻译: 一种制备根据通式(I)的化合物的方法,其中R是醇的烃基,其中一种或多种通式(II)的醇<β在线式描述=“In 线性公式“end =”lead“?> R-OH(II)<?in-line-formula description =”在线公式“end =”tail“?>其中R如上定义,被酯化, /或在不使用大量溶剂的情况下,优选不用溶剂,优选在低于100℃的温度下,在来自一类水解酶的酶与根据通式(III)的化合物存在下进行酯交换反应,其中R 提供氢或具有1〜3个碳原子的直链或支链烷基或链烯基。