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1.发明授权Compositions, use and method for the use of surface active proteins in topical drug delivery across keratin 有权组合物，使用和使用表面活性蛋白在角蛋白局部药物递送中的应用公开(公告)号：US08758730B2
公开(公告)日：2014-06-24
申请号：US13202112
申请日：2010-02-19
申请人： Andreas Buthe , Andreas Hafner , Franz Kaufmann , Babette Fiedler , Guido Meurer , Gordon Bradley
发明人： Andreas Buthe , Andreas Hafner , Franz Kaufmann , Babette Fiedler , Guido Meurer , Gordon Bradley
CPC分类号： A61K9/0014 , A61K31/522 , A61K38/02 , A61K45/06 , A61K47/42 , A61K2300/00
摘要： The present invention provides the use of surface active proteins, especially class I and class II hydrophobins, in topically applied pharmaceutical formulations. The invention is particularly directed to topically applied pharmaceutical products for enhancing the penetration to achieve a transungual delivery of a prophylactically and/or therapeutically effective amount of an active ingredient (drug) to a patient (including animals and humans) into and/or through a nail, of the animal or human body, in order to treat one or more of a variety of diseases or disorders. Related embodiments of the invention are also disclosed.
摘要翻译： 本发明提供了表面活性蛋白质，特别是I类和II类疏水蛋白在局部施用的药物制剂中的用途。 本发明特别涉及用于增强渗透性以实现预防和/或治疗有效量的活性成分（药物）向患者（包括动物和人）递送到和/或通过 指甲，动物或人体，以治疗各种疾病或病症中的一种或多种。 还公开了本发明的相关实施例。
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2.发明授权公开(公告)号：US08226967B2
公开(公告)日：2012-07-24
申请号：US13130128
申请日：2009-11-13
申请人： Andreas Buthe , Andreas Hafner , Franz Kaufmann , Esther Gabor , Guido Meurer , Jürgen Eck , Gordon Bradley
发明人： Andreas Buthe , Andreas Hafner , Franz Kaufmann , Esther Gabor , Guido Meurer , Jürgen Eck , Gordon Bradley
CPC分类号： A61K9/4891 , A61K9/0065 , A61K9/2063 , A61K9/2095 , A61K9/2873 , C07K14/37
摘要： The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e.g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.
摘要翻译： 本发明涉及用于制药技术中的表面活性疏水蛋白的用途，特别是作为涂覆液使用的赋形剂。 提供了将疏水蛋白与盖仑组合物混合或用含疏水蛋白的溶液处理药物形式的表面以改变盖仑膜形式的药物性质的方法。 在本发明的优选实施方案中，疏水蛋白用于改善药物组合物的性质，例如， 作为表面活性剂或增加耐受霜冻形式的崩解以实现延缓药物释放。 通过使用表面活性蛋白质作为赋形剂来修饰的盖仑形式可以是胶囊，片剂，丸剂，微粒，囊泡和栓剂，尽管可以预见到更多的盖仑制剂形式。 用于本发明目的的表面活性蛋白质可以从其各自的天然来源分离或通过重组技术制备并在合适的宿主中表达。
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公开(公告)号：US08394618B2
公开(公告)日：2013-03-12
申请号：US12820063
申请日：2010-06-21
申请人： Andreas Buthe , Ping Wang , Songtao Wu , Hongfei Jia , Masahiko Ishii , Minjuan Zhang
发明人： Andreas Buthe , Ping Wang , Songtao Wu , Hongfei Jia , Masahiko Ishii , Minjuan Zhang
CPC分类号： C12N9/20 , C12N11/08 , D06M10/001
摘要： A substrate or coating is provided that includes a lipase with enzymatic activity toward a component of a fingerprint. Also provided is a process for facilitating the removal of fingerprints is provided wherein an inventive substrate or coating including a lipase is capable of enzymatically degrading of one or more components of the fingerprint to facilitate fingerprint removal from the substrate or said coating. Applying heat to the substrate or coating increases the rate of fingerprint removal.
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公开(公告)号：US08383088B2
公开(公告)日：2013-02-26
申请号：US12528357
申请日：2008-02-29
申请人： Barbara Wagner , Sébastien Mongiat , Bernd Herzog , Werner Baschong , Andreas Buthe , Reinhold Öhrlein
发明人： Barbara Wagner , Sébastien Mongiat , Bernd Herzog , Werner Baschong , Andreas Buthe , Reinhold Öhrlein
IPC分类号： A61K8/00 , A61K8/18 , A61Q17/04 , A61Q1/02 , A61Q19/04 , A61Q1/00 , A61Q1/12 , A61Q5/00 , A61Q9/00
CPC分类号： C07D493/04 , A61K8/4973 , A61K8/498 , A61K2800/522 , A61Q17/04 , C07D491/04
摘要： The present invention relates to derivatives of the 1H-pyrano[4,3-b]benzofuran-1-one structure and their nitrogen analogues which possess powerful antioxidant properties combined with a highly effective UV absorbing functionality in one molecule. These compounds are especially useful in cosmetical and dermatological formulations.
摘要翻译： 本发明涉及具有强大抗氧化性能的1H-吡喃并[4,3-b]苯并呋喃-1-酮结构的衍生物及其在一个分子中与高效UV吸收官能团结合的氮类似物。 这些化合物在美容和皮肤病学制剂中特别有用。
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公开(公告)号：US20110159050A1
公开(公告)日：2011-06-30
申请号：US13002777
申请日：2009-06-23
IPC分类号： A61K9/14 , C07C233/25 , A61K31/167 , C07C233/65 , A61K31/166 , C07D207/34 , A61K31/40 , C07C215/64 , A61K31/137
CPC分类号： B01D9/005 , A61K9/1688 , C07K14/37
摘要： Disclosed is a process for modifying the morphology and/or polymorphism of an organic substance, which process comprises treating the solid substance, or a solution or dispersion thereof, with one or more amphiphilic proteins.
摘要翻译： 公开了一种用于改变有机物质的形态和/或多态性的方法，该方法包括用一种或多种两亲性蛋白质处理固体物质或其溶液或分散体。
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公开(公告)号：US08455107B2
公开(公告)日：2013-06-04
申请号：US12528366
申请日：2008-02-27
申请人： Esther Gabor , Andreas Buthe , Jürgen Eck , Franz Kaufmann , Hans-Jörg Koch , Guido Meurer
发明人： Esther Gabor , Andreas Buthe , Jürgen Eck , Franz Kaufmann , Hans-Jörg Koch , Guido Meurer
IPC分类号： B32B23/04
CPC分类号： D21H17/22 , B27K3/002 , B27K3/15 , B27K2240/70 , C08L89/00 , C08L97/02 , D06M15/15 , D21C5/005 , D21H17/005 , D21H19/50 , Y10T428/31971 , Y10T428/31978 , Y10T428/31986 , Y10T428/31989 , Y10T428/31993
摘要： By treatment with hydrophobins, cellulosic materials such as paper, cardboard, cotton or, especially, wood-based materials, such as solid wood, glued wood products or particle board, can be effectively protected against absorption of and attack by water and/or moisture.
摘要翻译： 通过用疏水蛋白处理，可以有效地防止纤维素材料如纸，纸板，棉花，或特别是木质材料，例如实木，胶木制品或刨花板，以防止水和/或水分的吸收和侵袭 。
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7.发明申请Coatings Containing Polymer Modified Enzyme For Stable Self-Cleaning Of Organic Stains 有权含有聚合物改性酶的涂料用于有机污渍的稳定自清洁公开(公告)号：US20130065291A1
公开(公告)日：2013-03-14
申请号：US13229277
申请日：2011-09-09
申请人： Hongfei Jia , Ping Wang , Liting Zhang , Andreas Buthe , Xueyan Zhao , Songtao Wu , Masahiko Ishii , Minjuan Zhang
发明人： Hongfei Jia , Ping Wang , Liting Zhang , Andreas Buthe , Xueyan Zhao , Songtao Wu , Masahiko Ishii , Minjuan Zhang
IPC分类号： C09D189/00
CPC分类号： C09D189/00 , A61K47/60 , C08G65/33337 , C08L2203/02 , C08L2205/02 , C09D5/024 , C09D7/40 , C09D175/16 , C12N9/14 , C12N9/20 , C12N9/2408 , C12N9/2411 , C12N9/54 , C12N9/96 , C12N11/06 , C12N11/08
摘要： Bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.
摘要翻译： 提供了通过耐风化来防止灭活的生物活性涂层，包括与化学修饰的酶相关的碱，以及任选地存在于碱中并独立于酶的第一聚氧乙烯。 涂层任选地覆盖在基底上以形成有助于从食品，昆虫或环境中去除有机污渍或有机材料的活性涂层。
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公开(公告)号：US20090017519A1
公开(公告)日：2009-01-15
申请号：US12168350
申请日：2008-07-07
CPC分类号： C12N11/08 , C09D183/04 , C12N11/00
摘要： The invention is directed to enzyme preparations which are obtainable by enzyme immobilizates which comprise enzymes or microorganisms containing enzymes immobilized on an inert carrier being provided with a silicone coating obtained by hydrosilylation, to a process for producing such enzyme preparations and to the use of enzyme preparations as an industrial biocatalyst.
摘要翻译： 本发明涉及可通过酶制剂获得的酶制剂，其包含酶或微生物，其含有固定在惰性载体上的酶，其中提供有通过氢化硅烷化获得的硅氧烷涂层，制备该酶制剂的方法和使用酶制剂 作为工业生物催化剂。
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公开(公告)号：US08404470B2
公开(公告)日：2013-03-26
申请号：US12168350
申请日：2008-07-07
IPC分类号： C12N11/08
CPC分类号： C12N11/08 , C09D183/04 , C12N11/00
摘要： The invention is directed to enzyme preparations which are obtainable by enzyme immobilizates which comprise enzymes or microorganisms containing enzymes immobilized on an inert carrier being provided with a silicone coating obtained by hydrosilylation, to a process for producing such enzyme preparations and to the use of enzyme preparations as an industrial biocatalyst.
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10.发明申请公开(公告)号：US20110268792A1
公开(公告)日：2011-11-03
申请号：US13130128
申请日：2009-11-13
申请人： Andreas Buthe , Andreas Hafner , Franz Kaufmann , Esther Gabor , Guido Meurer , Jürgen Eck , Gordon Bradley
发明人： Andreas Buthe , Andreas Hafner , Franz Kaufmann , Esther Gabor , Guido Meurer , Jürgen Eck , Gordon Bradley
CPC分类号： A61K9/4891 , A61K9/0065 , A61K9/2063 , A61K9/2095 , A61K9/2873 , C07K14/37
摘要： The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e.g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.
摘要翻译： 本发明涉及用于制药技术中的表面活性疏水蛋白的用途，特别是作为涂覆液使用的赋形剂。 提供了将疏水蛋白与盖仑组合物混合或用含疏水蛋白的溶液处理药物形式的表面以改变盖仑膜形式的药物性质的方法。 在本发明的优选实施方案中，疏水蛋白用于改善药物组合物的性质，例如， 作为表面活性剂或增加耐受霜冻形式的崩解以实现延缓药物释放。 通过使用表面活性蛋白质作为赋形剂来修饰的盖仑形式可以是胶囊，片剂，丸剂，微粒，囊泡和栓剂，尽管可以预见到更多的盖仑制剂形式。 用于本发明目的的表面活性蛋白质可以从它们各自的天然来源中分离或者通过重组技术制备并在合适的宿主中表达。
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