公开(公告)号：US06662030B2

公开(公告)日：2003-12-09

申请号：US09080470

申请日：1998-05-18

申请人： Omar S. Khalil ,  Frits F. M. de Mul ,  Charles F. Hanna ,  Arnold F. Stalder ,  Shu-jen Yeh ,  Xiaomao Wu ,  Michael G. Lowery ,  Johannes S. Kanger ,  René A. Bolt

发明人： Omar S. Khalil ,  Frits F. M. de Mul ,  Charles F. Hanna ,  Arnold F. Stalder ,  Shu-jen Yeh ,  Xiaomao Wu ,  Michael G. Lowery ,  Johannes S. Kanger ,  René A. Bolt

IPC分类号： A61B500

CPC分类号： A61B5/1491 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/6824 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043 ,  G01N21/4795

摘要： Devices and methods for non-invasively measuring at least one parameter of a sample, such as the presence or concentration of an analyte, in a body part wherein the temperature is controlled. The present invention measures light that is reflected, scattered, absorbed, or emitted by the sample from an average sampling depth, dav, that is confined within a temperature controlled region in the tissue. This average sampling depth is preferably less than 2 mm, and more preferably less than 1 mm. Confining the sampling depth into the tissue is achieved by appropriate selection of the separation between the source and the detector and the illumination wavelengths. In another aspect, the invention involves a method and apparatus for non-invasively measuring at least one parameter of a body part with temperature stepping. In another aspect, the invention involves a method and apparatus for non-invasively measuring at least one parameter of a body part with temperature modulation. In another aspect, the invention provides an improved method of measuring at least one parameter of a tissue sample comprising the steps of: (a) lowering the temperature of said tissue sample to a temperature that is lower than the normal physiological temperature of the body; and (b) determining at least one optical property of said tissue sample.

摘要翻译： 用于非侵入性地测量样品的至少一个参数（例如分析物的存在或浓度）在其中控制温度的身体部位中的装置和方法。 本发明测量被从组织中的温度控制区域内限定的平均采样深度dav反射，散射，吸收或发射的光。 该平均采样深度优选小于2mm，更优选小于1mm。 通过适当选择源和检测器之间的距离以及照明波长来实现将采样深度限制在组织中。 在另一方面，本发明涉及一种用于非侵入性地测量具有温度步进的身体部位的至少一个参数的方法和装置。 在另一方面，本发明涉及一种用于通过温度调制非侵入性地测量身体部位的至少一个参数的方法和装置。 另一方面，本发明提供了一种测量组织样本的至少一个参数的改进方法，包括以下步骤：（a）将所述组织样本的温度降低到低于身体的正常生理温度的温度; 和（b）确定所述组织样品的至少一种光学性质。