公开(公告)号：US20240254462A1

公开(公告)日：2024-08-01

申请号：US18405286

申请日：2024-01-05

申请人： Omega Therapeutics, Inc.

发明人： Laura Anh Nguyen ,  Jeremiah D. Farelli ,  Adam Walter Scheidegger ,  Abigail Elizabeth Witt ,  Justin Chen ,  James Scott Sullivan

IPC分类号： C12N9/22 ,  A61K9/51 ,  A61K38/00 ,  C12N9/10 ,  C12N15/113 ,  C12N15/86

CPC分类号： C12N9/22 ,  A61K9/5123 ,  C12N9/1007 ,  C12N15/113 ,  C12N15/86 ,  A61K38/00 ,  C07K2319/81 ,  C12N2310/20 ,  C12Y305/01098

摘要： The present invention provides agents and compositions for modulating expression (e.g., enhanced or reduced expression) of a secreted frizzled related protein 1 (SFRP1) gene by targeting an SFRP1 expression control region and methods of use thereof for treating an SFRP1 associated disorder, e.g., hair loss.