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公开(公告)号：US10716548B2
公开(公告)日：2020-07-21
申请号：US15366230
申请日：2016-12-01
发明人： Yair Pilpel , Sivan Doron , Yuri Zherdev , Lior Erez , Ashley DeAnglis
摘要： The invention relates to syringes for storing and mixing components.
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公开(公告)号：US11246579B2
公开(公告)日：2022-02-15
申请号：US16910698
申请日：2020-06-24
发明人： Yair Pilpel , Sivan Doron , Yuri Zherdev , Lior Erez , Ashley DeAnglis
摘要： The invention relates to syringes for storing and mixing components.
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3.发明申请DEVICE AND METHOD FOR PREPARING AND ADMINISTERING ONE-COMPONENT FIBRIN SEALANT 审中-公开用于制备和管理单组分纤维素密封剂的装置和方法公开(公告)号：US20150272562A1
公开(公告)日：2015-10-01
申请号：US14668341
申请日：2015-03-25
发明人： Ashley DeAnglis , Yair Pilpel , Yuri Zherdev , Sivan Doron , Lior Erez
CPC分类号： A61B17/00491 , A61K38/36 , A61K38/363 , A61K38/4833 , A61L24/106 , A61M3/005 , A61M2202/045 , C12Y304/21005
摘要： Provided herein are systems for preparing and delivering fibrin sealant to a surface and methods of use thereof. In one embodiment, the system comprises: a. a quantity of a liquid mixture disposed within a container, the mixture comprising: I. fibrin or II. fibrinogen and Factor II; and b. a resin bed disposed within a vessel, the vessel capable of being in fluid communication with the container, wherein when in fluid communication, passage of the mixture through the vessel results in modification of the concentration of small molecules inhibitor(s) and/or inducer(s) within the mixture, favoring fibrin clot formation.
摘要翻译： 本文提供了用于制备和递送纤维蛋白密封剂到表面的系统及其使用方法。 在一个实施例中，系统包括：a。 一定量的液体混合物置于容器内，该混合物包括：I.血纤蛋白或II。 纤维蛋白原和因子II; 和b。 设置在容器内的树脂床，容器能够与容器流体连通，其中当流体连通时，混合物通过容器导致改变小分子抑制剂和/或诱导剂的浓度 在混合物中，有利于血纤维蛋白凝块的形成。
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公开(公告)号：US11957324B2
公开(公告)日：2024-04-16
申请号：US17318740
申请日：2021-05-12
发明人： Ashley DeAnglis , Yair Pilpel , Yuri Zherdev , Sivan Doron , Lior Erez
CPC分类号： A61B17/00491 , A61K38/36 , A61K38/363 , A61K38/4833 , A61L24/106 , A61M3/005 , A61M2202/045 , C12Y304/21005
摘要： Provided herein are systems for preparing and delivering fibrin sealant to a surface and methods of use thereof. In one embodiment, the system comprises: a. a quantity of a liquid mixture disposed within a container, the mixture comprising: I. fibrin or II. fibrinogen and Factor II; and b. a resin bed disposed within a vessel, the vessel capable of being in fluid communication with the container, wherein when in fluid communication, passage of the mixture through the vessel results in modification of the concentration of small molecules inhibitor(s) and/or inducer(s) within the mixture, favoring fibrin clot formation.
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公开(公告)号：US20210267581A1
公开(公告)日：2021-09-02
申请号：US17318740
申请日：2021-05-12
发明人： Ashley DeAnglis , Yair Pilpel , Yuri Zherdev , Sivan Doron , Lior Erez
摘要： Provided herein are systems for preparing and delivering fibrin sealant to a surface and methods of use thereof. In one embodiment, the system comprises: a. a quantity of a liquid mixture disposed within a container, the mixture comprising: I. fibrin or II. fibrinogen and Factor II; and b. a resin bed disposed within a vessel, the vessel capable of being in fluid communication with the container, wherein when in fluid communication, passage of the mixture through the vessel results in modification of the concentration of small molecules inhibitor(s) and/or inducer(s) within the mixture, favoring fibrin clot formation.
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公开(公告)号：US11020100B2
公开(公告)日：2021-06-01
申请号：US16412487
申请日：2019-05-15
发明人： Ashley DeAnglis , Yair Pilpel , Yuri Zherdev , Sivan Doron , Lior Erez
摘要： Provided herein are systems for preparing and delivering fibrin sealant to a surface and methods of use thereof. In one embodiment, the system comprises: a. a quantity of a liquid mixture disposed within a container, the mixture comprising: I. fibrin or II. fibrinogen and Factor II; and b. a resin bed disposed within a vessel, the vessel capable of being in fluid communication with the container, wherein when in fluid communication, passage of the mixture through the vessel results in modification of the concentration of small molecules inhibitor(s) and/or inducer(s) within the mixture, favoring fibrin clot formation.
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公开(公告)号：US10433825B2
公开(公告)日：2019-10-08
申请号：US14668341
申请日：2015-03-25
发明人： Ashley DeAnglis , Yair Pilpel , Yuri Zherdev , Sivan Doron , Lior Erez
摘要： Provided herein are systems for preparing and delivering fibrin sealant to a surface and methods of use thereof. In one embodiment, the system comprises: a. a quantity of a liquid mixture disposed within a container, the mixture comprising: I. fibrin or II. fibrinogen and Factor II; and b. a resin bed disposed within a vessel, the vessel capable of being in fluid communication with the container, wherein when in fluid communication, passage of the mixture through the vessel results in modification of the concentration of small molecules inhibitor(s) and/or inducer(s) within the mixture, favoring fibrin clot formation.
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公开(公告)号：US20200315601A1
公开(公告)日：2020-10-08
申请号：US16910698
申请日：2020-06-24
发明人： Yair Pilpel , Sivan Doron , Yuri Zherdev , Lior Erez , Ashley DeAnglis
摘要： The invention relates to syringes for storing and mixing components.
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公开(公告)号：US20190314006A1
公开(公告)日：2019-10-17
申请号：US16412487
申请日：2019-05-15
发明人： Ashley DeAnglis , Yair Pilpel , Yuri Zherdev , Sivan Doron , Lior Erez
摘要： Provided herein are systems for preparing and delivering fibrin sealant to a surface and methods of use thereof. In one embodiment, the system comprises: a. a quantity of a liquid mixture disposed within a container, the mixture comprising: I. fibrin or II. fibrinogen and Factor II; and b. a resin bed disposed within a vessel, the vessel capable of being in fluid communication with the container, wherein when in fluid communication, passage of the mixture through the vessel results in modification of the concentration of small molecules inhibitor(s) and/or inducer(s) within the mixture, favoring fibrin clot formation.
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公开(公告)号：US20170156714A1
公开(公告)日：2017-06-08
申请号：US15366230
申请日：2016-12-01
发明人： Yair Pilpel , Sivan Doron , Yuri Zherdev , Lior Erez , Ashley DeAnglis
摘要： The invention relates to syringes for storing and mixing components.
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