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公开(公告)号：US20230174484A1
公开(公告)日：2023-06-08
申请号：US17997533
申请日：2021-04-30
发明人： Sanjiv KAUL , Nabil ALKAYED , Shanthi NAGARAJAN , Agostino CIANCIULLI , Fabrizio MICHELI , Teresa SEMERARO , Iuni Margaret Laura TRIST
IPC分类号： C07D209/54 , C07D207/06 , C07D267/10 , C07D491/107 , C07D211/38 , C07D231/12 , C07D207/327 , C07D295/192 , C07D213/56 , C07D209/52 , C07D211/14 , C07D217/04 , C07D223/04 , C07D261/08 , C07D263/32 , C07D213/36 , C07D495/04 , C07D217/06 , C07D487/04 , C07D213/40 , C07D295/155 , C07D213/74 , C07D401/04 , C07D417/10 , C07D401/10 , C07D403/10 , C07D409/14 , C07D403/04 , C07D409/04 , C07D241/04 , C07D413/06 , C07D249/14 , C07D241/26 , C07D213/81 , C07D249/12 , C07D249/08 , C07D401/12 , C07F5/02 , C07D413/10 , C07D401/14 , C07D265/30 , C07D279/12 , C07D491/08 , C07D221/22 , C07D265/34 , A61P9/12 , A61P9/10
CPC分类号： C07D209/54 , C07D207/06 , C07D267/10 , C07D491/107 , C07D211/38 , C07D231/12 , C07D207/327 , C07D295/192 , C07D213/56 , C07D209/52 , C07D211/14 , C07D217/04 , C07D223/04 , C07D261/08 , C07D263/32 , C07D213/36 , C07D495/04 , C07D217/06 , C07D487/04 , C07D213/40 , C07D295/155 , C07D213/74 , C07D401/04 , C07D417/10 , C07D401/10 , C07D403/10 , C07D409/14 , C07D403/04 , C07D409/04 , C07D241/04 , C07D413/06 , C07D249/14 , C07D241/26 , C07D213/81 , C07D249/12 , C07D249/08 , C07D401/12 , C07F5/025 , C07D413/10 , C07D401/14 , C07D265/30 , C07D279/12 , C07D491/08 , C07D221/22 , C07D265/34 , A61P9/12 , A61P9/10
摘要： Novel compounds that act as antagonists to human GPR39 protein are disclosed. Pharmaceutical compositions and methods of use for antagonists to human GPR39 protein are disclosed. In particular, methods of using the antagonists in the treatment of diseases or conditions including cardiovascular conditions, endocrine system and hormone disorders, cancer disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, neurological disorders and respiratory diseases are disclosed herein.
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