-
公开(公告)号：US10688164B2
公开(公告)日：2020-06-23
申请号：US15356627
申请日：2016-11-20
发明人： Jay Nelson , Scott Hansen , Meaghan H. Hancock , Louis Picker , Klaus Frueh
摘要： Disclosed herein are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an active UL128 protein and an active UL130 protein. Also disclosed are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an inactive UL128 protein and an inactive UL130 protein. Also disclosed are methods of generating an unconventional immune response using these vectors. Such an immune response is characterized by generation of a CD8+ T cell response that is predominantly restricted by MHC-II.
-
公开(公告)号：US10428118B2
公开(公告)日：2019-10-01
申请号：US15326444
申请日：2015-07-16
发明人： Klaus Frueh , Scott G. Hansen , Jay Nelson , Louis Picker , Patrizia Caposio
IPC分类号： C07K14/045 , C12N15/86 , A61K39/12 , A61K35/33 , A61K39/00 , A61K39/39 , C12N15/85 , A61K39/21 , C07K14/16 , A61P35/00
摘要： Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.
-
公开(公告)号：US20180282378A1
公开(公告)日：2018-10-04
申请号：US15326444
申请日：2015-07-16
发明人： Klaus Frueh , Scott G. Hansen , Jay Nelson , Louis Picker , Patrizia Caposio
CPC分类号： C07K14/045 , A61K35/33 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/5254 , A61K2039/5256 , A61K2039/572 , A61P35/00 , C07K14/161 , C12N15/85 , C12N15/86 , C12N2710/16143 , C12N2740/15034 , C12N2740/16234
摘要： Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.
-
4.发明授权公开(公告)号：US10532099B2
公开(公告)日：2020-01-14
申请号：US15786847
申请日：2017-10-18
发明人： Louis Picker , Scott Hansen , Klaus Frueh , Daniel Malouli , Jay Nelson , Jonah Sacha , Meaghan Hancock
摘要： Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV. Immunization with the disclosed CMV vectors allow selection of different CD8+ T cell responses—CD8+ T cells restricted by MHC-Ia, MHC-II, or by MHC-E.
-
5.发明申请公开(公告)号：US20180133321A1
公开(公告)日：2018-05-17
申请号：US15786847
申请日：2017-10-18
发明人： Louis Picker , Scott Hansen , Klaus Frueh , Daniel Malouli , Jay Nelson , Jonah Sacha , Meaghan Hancock
摘要： Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV. Immunization with the disclosed CMV vectors allow selection of different CD8+ T cell responses—CD8+ T cells restricted by MHC-Ia, MHC-II, or by MHC-E.
-
公开(公告)号：US11692012B2
公开(公告)日：2023-07-04
申请号：US17214598
申请日：2021-03-26
发明人： Klaus Frueh , Scott G. Hansen , Jay Nelson , Louis Picker , Patrizia Caposio
IPC分类号： C07K14/045 , A61K39/12 , C12N15/86 , A61K35/33 , A61K39/00 , A61K39/39 , C12N15/85 , A61K39/21 , C07K14/16 , A61P35/00
CPC分类号： C07K14/045 , A61K35/33 , A61K39/0011 , A61K39/12 , A61K39/39 , C12N15/85 , C12N15/86 , A61K39/21 , A61K2039/5254 , A61K2039/5256 , A61K2039/572 , A61P35/00 , C07K14/161 , C12N2710/16143 , C12N2740/15034 , C12N2740/16234
摘要： Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.
-
7.发明授权公开(公告)号：US11305015B2
公开(公告)日：2022-04-19
申请号：US16696403
申请日：2019-11-26
发明人： Louis Picker , Scott Hansen , Klaus Frueh , Daniel Malouli , Jay Nelson , Jonah Sacha , Meaghan Hancock
IPC分类号： A61K45/00 , A61K39/00 , A61K39/12 , C12N7/04 , C12N15/86 , C12N15/113 , A61P31/14 , C07K14/005
摘要： CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV are provided. Immunization with CMV vectors having the described features allows selection of different CD8+ T cell responses—CD8+ T cells restricted by MHC-Ia, MHC-II, or by MHC-E.
-
公开(公告)号：US10995121B2
公开(公告)日：2021-05-04
申请号：US16545561
申请日：2019-08-20
发明人： Klaus Frueh , Scott G. Hansen , Jay Nelson , Louis Picker , Patrizia Caposio
IPC分类号： C07K14/045 , A61K39/12 , C12N15/86 , A61K35/33 , A61K39/00 , A61K39/39 , C12N15/85 , A61K39/21 , C07K14/16 , A61P35/00
摘要： Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.
-
9.发明申请公开(公告)号：US20200237915A1
公开(公告)日：2020-07-30
申请号：US16696403
申请日：2019-11-26
发明人： Louis PICKER , Scott Hansen , Klaus Frueh , Daniel Malouli , Jay Nelson , Jonah Sacha , Meaghan Hancock
IPC分类号： A61K45/00 , A61K39/12 , A61P31/14 , C12N15/86 , C12N15/113 , C07K14/005 , C12N7/04 , A61K39/00
摘要： Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV. Immunization with the disclosed CMV vectors allow selection of different CD8+ T cell responses—CD8+ T cells restricted by MHC-Ia, MHC-II, or by MHC-E.
-
公开(公告)号：US20170143809A1
公开(公告)日：2017-05-25
申请号：US15356627
申请日：2016-11-20
发明人： Jay Nelson , Scott Hansen , Meaghan H. Hancock , Louis Picker , Klaus Frueh
IPC分类号： A61K39/00
摘要： Disclosed herein are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an active UL128 protein and an active UL130 protein. Also disclosed are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an inactive UL128 protein and an inactive UL130 protein. Also disclosed are methods of generating an unconventional immune response using these vectors. Such an immune response is characterized by generation of a CD8+ T cell response that is predominantly restricted by MHC-II.
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.021 秒)
