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公开(公告)号：US11447530B2
公开(公告)日：2022-09-20
申请号：US16465444
申请日：2017-12-01
发明人： T. Mark Zabriskie , Xihou Yin
摘要： This disclosure describes compositions and methods for enhanced production of enduracidin in genetically engineered strains of Streptomyces fungicidicus. In particular, the present disclosure describes the genetic manipulation of regulatory genes orf24 and orf18 associated with the enduracidin (enramycin) biosynthesis gene cluster from Streptomyces fungicidicus to generate vector constructs and recombinant strains producing greater yields of enduracidin.
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公开(公告)号：US11858967B2
公开(公告)日：2024-01-02
申请号：US17817413
申请日：2022-08-04
发明人： T. Mark Zabriskie , Xihou Yin
CPC分类号： C07K14/36 , C12N15/71 , C12P21/02 , C12N1/205 , C12R2001/465
摘要： This disclosure describes compositions and methods for enhanced production of enduracidin in genetically engineered strains of Streptomyces fungicidicus. In particular, the present disclosure describes the genetic manipulation of regulatory genes orf24 and orf18 associated with the enduracidin (enramycin) biosynthesis gene cluster from Streptomyces fungicidicus to generate vector constructs and recombinant strains producing greater yields of enduracidin.
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公开(公告)号：US20230120672A1
公开(公告)日：2023-04-20
申请号：US17817413
申请日：2022-08-04
发明人： T. Mark Zabriskie , Xihou Yin
摘要： This disclosure describes compositions and methods for enhanced production of enduracidin in genetically engineered strains of Streptomyces fungicidicus. In particular, the present disclosure describes the genetic manipulation of regulatory genes orf24 and orf18 associated with the enduracidin (enramycin) biosynthesis gene cluster from Streptomyces fungicidicus to generate vector constructs and recombinant strains producing greater yields of enduracidin.
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