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1.发明公开公开(公告)号：US20240240214A1
公开(公告)日：2024-07-18
申请号：US18561867
申请日：2022-05-17
发明人： Kechun ZHANG , Jingyu WANG , Jilong WANG
CPC分类号： C12P13/06 , C12N9/1022 , C12N9/88 , C12R2001/07 , C12R2001/15 , C12R2001/19 , C12R2001/465 , C12Y202/01006 , C12Y403/01019
摘要： A method for producing L-isoleucine at a higher yield by fermentation includes the step of using a genetic engineering method to obtain a genetically engineered strain. The genetically engineered strain has a threonine deaminase gene substantially releasing the inhibition of L-isoleucine and/or an acetylated hydroxy acid synthetase III gene substantially releasing the inhibition of L-isoleucine; and performing fermentation culture on the genetically engineered strain, adding diketobutyric acid or a raw material capable of being converted into diketobutyric acid in a culture process, and separating L-isoleucine from a culture after the end of culturing. Further provided is a genetically engineered strain for realizing high yield of L-isoleucine.
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公开(公告)号：US20240032545A1
公开(公告)日：2024-02-01
申请号：US18340513
申请日：2023-06-23
发明人： Lirong Han , Zhichun Yuan , Hao Wu , Shanshan Xu , Tingting Yu
CPC分类号： A01N63/28 , C12N1/205 , A01P3/00 , C05G3/60 , C12R2001/465
摘要： The present disclosure belongs to the technical field of microorganisms, and provides Streptomyces ardesiacus, a microbial biological control agent (MBCA) and use. The use specifically refers to prevention and treatment of various plant diseases. In the present disclosure, the Streptomyces ardesiacus has a serial number of HL-06, and has been deposited on Jun. 9, 2022, with a deposit number of CGMCC No. 25033. The HL-06 strain can degrade organic phosphorus and inorganic phosphorus, has a broad-spectrum antimicrobial activity, and can stimulate various defense enzymes of plants to improve disease resistance of the plants.
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公开(公告)号：US20240351985A1
公开(公告)日：2024-10-24
申请号：US18684596
申请日：2022-08-18
申请人： APHEA.BIO NV , Fundación Centro De Excelencia En Investigación De Medicamentos Innovadores En Andalucía, Medina
发明人： Ignacio PÉREZ-VICTORIA MORENO DE BARREDA , José Rubén TORMO BELTRÁN , Steven VANDENABEELE , Thomas SIMON , Isabel VERCAUTEREN , Victor Manuel GONZÁLEZ MENÉNDEZ
IPC分类号： C07D211/42 , A01N37/36 , A01N43/40 , A01P3/00 , C07C233/05 , C12N1/20 , C12R1/465
CPC分类号： C07D211/42 , A01N37/36 , A01N43/40 , A01P3/00 , C07C233/05 , C12N1/205 , C12R2001/465
摘要： The current invention is directed to a novel compound and compositions having said compound, wherein said compound is a compound according to formula I or formula II, or an acceptable salt thereof. The invention also relates to specific uses of said compound, particularly as antimicrobial agent.
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公开(公告)号：US20240084287A1
公开(公告)日：2024-03-14
申请号：US18327345
申请日：2023-06-01
发明人： Paul Blainey , Navpreet Ranu , Todd Gierahn , J. Christopher Love
IPC分类号： C12N15/10 , C12N1/20 , C12Q1/6806 , C12Q1/6869 , C40B30/04 , C40B40/06 , C40B40/10 , C40B50/06
CPC分类号： C12N15/1006 , C12N1/205 , C12Q1/6806 , C12Q1/6869 , C40B30/04 , C40B40/06 , C40B40/10 , C40B50/06 , C12N2310/20 , C12R2001/465 , C12Y301/11 , C12Y302/02027
摘要： The present invention relates to the analysis of complex single cell sequencing libraries. Disclosed are methods for enrichment of library members based on the presence of cell-of origin barcodes to identify and concentrate DNA that is relevant to interesting cells or components that would be expensive or difficult to study otherwise. Also, disclosed are methods of capturing cDNA library molecules by use of CRISPR systems, hybridization or PCR. The present invention allows for identifying the properties of rare cells in single cell RNA-seq data and accurately profile them through clustering approaches. Further information on transcript abundances from subpopulations of single cells can be analyzed at a lower sequencing effort. The methods also allow for linking TCR alpha and beta chains at the single cell level.
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公开(公告)号：US11882838B2
公开(公告)日：2024-01-30
申请号：US16608421
申请日：2018-04-27
CPC分类号： A01N63/10 , C12N1/20 , C12N1/205 , C12R2001/465
摘要： The present disclosure relates to bacterial inoculants, and methods for their use, to control a fungal root disease in a plant and promote plant growth in water limited conditions. In particular strains of Paenibacillus and Streptomyces are disclosed.
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公开(公告)号：US20240182525A1
公开(公告)日：2024-06-06
申请号：US18282160
申请日：2022-03-14
发明人： Jong Seog AHN , Jun Pil JANG , Jae-Hyuk JANG , Sung-Kyun KO , Min Cheol KWON , Gui Ja HWANG , Jae-Won LEE
摘要： The present invention provides a compound represented by chemical formula 1, an optical isomer thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for preventing or treating Wnt/β-catenin signaling-associated diseases, comprising same.
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公开(公告)号：US20240124831A1
公开(公告)日：2024-04-18
申请号：US18278242
申请日：2022-02-22
申请人： YEAP LTD.
发明人： Didier TOUBIA , Dominik GRABINSKI , Keren KLES , Yonatan GOSHEN
CPC分类号： C12N1/063 , A23J1/18 , A23J3/20 , C12N1/066 , C12R2001/465
摘要： Disclosed herein is a method for separating a protein from a microorganism comprising a cell wall. Further compositions comprising a first fraction, a second fraction or both, derived from a microorganism comprising a cell wall and comprising a protein content between 10% and 90% by weight of the fraction, are also disclosed.
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公开(公告)号：US20240016158A1
公开(公告)日：2024-01-18
申请号：US18036743
申请日：2021-11-11
发明人： Jin Cheol KIM , Thi Thu Hang NGUYEN , Ae Ran PARK , Nan Hee YU
CPC分类号： A01N63/28 , C12N1/205 , A01P3/00 , G01N30/02 , C12R2001/465
摘要： The present disclosure relates to a plant disease control composition comprising a culture broth of Streptomyces sp. JCK-6141 strain or an extract of the culture broth of the strain, a preparation method therefor and a plant disease control method. The culture broth of the strain or an extract thereof exhibits extremely excellent antimicrobial activity when applied to a causative pathogen of plant disease and thus may be effectively used for plant disease control.
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公开(公告)号：US11858967B2
公开(公告)日：2024-01-02
申请号：US17817413
申请日：2022-08-04
发明人： T. Mark Zabriskie , Xihou Yin
CPC分类号： C07K14/36 , C12N15/71 , C12P21/02 , C12N1/205 , C12R2001/465
摘要： This disclosure describes compositions and methods for enhanced production of enduracidin in genetically engineered strains of Streptomyces fungicidicus. In particular, the present disclosure describes the genetic manipulation of regulatory genes orf24 and orf18 associated with the enduracidin (enramycin) biosynthesis gene cluster from Streptomyces fungicidicus to generate vector constructs and recombinant strains producing greater yields of enduracidin.
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公开(公告)号：US12018305B2
公开(公告)日：2024-06-25
申请号：US17311783
申请日：2019-12-10
CPC分类号： C12P17/181 , C12N1/205 , C12R2001/465
摘要： A fermentation process is provided for the synthesis of Nigericin from Streptomyces sp. having accession number MCC 0151 and its isolation with high yield. A microbial inoculant composition is provided, comprising a biologically pure culture of Streptomyces sp. MCC 0151 for the exclusive production of Nigericin with high yield.
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