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公开(公告)号：US11896643B2
公开(公告)日：2024-02-13
申请号：US16967288
申请日：2019-02-05
Applicant: Orionis Biosciences, Inc. , VIB VZW , Universiteit Gent
Inventor： Nikolai Kley , Jan Tavernier , Anje Cauwels
IPC: A61K38/16 , A61K31/704 , C07K14/555
CPC classification number: A61K38/16 , A61K31/704 , C07K14/555 , C07K2317/24 , C07K2317/565 , C07K2317/569
Abstract: The present invention relates, in part, to agents that bind fibroblast activation protein (FAP) and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the FAP binding agents and their use in the treatment of various diseases.
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公开(公告)号：US11702477B2
公开(公告)日：2023-07-18
申请号：US15773857
申请日：2016-11-07
Applicant: Orionis Biosciences BV , VIB VZW , Universiteit Gent
Inventor： Nikolai Kley , Jan Tavernier , Leander Huyghe , Thomas Wueest
IPC: C07K16/28 , C07K14/525 , A61P35/00 , C07K14/505 , C07K14/52 , C12N15/62
CPC classification number: C07K16/2875 , A61P35/00 , C07K14/505 , C07K14/52 , C07K14/525 , C12N15/62 , C07K2317/569 , C07K2319/33 , C07K2319/75
Abstract: The present invention relates, in part, to targeted chimeric proteins with beneficial therapeutic effects, including, for example, effects mediated by mutant forms of soluble agents that are part of the chimeric proteins. Pharmaceutical compositions comprising the chimeric proteins are also provided. The present invention finds use in the treatment of various disease and disorders.
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公开(公告)号：US11753463B2
公开(公告)日：2023-09-12
申请号：US16301299
申请日：2017-05-12
Applicant: Orionis Biosciences BV , VIB VZW , Universiteit Gent
Inventor： Nikolai Kley , Jan Tavernier , Leander Huyghe , Anje Cauwels
IPC: C07K16/28 , C07K14/56 , A61K39/395 , A61K38/21 , A61P35/00 , C07K16/18 , A61K31/704 , A61K38/19 , C07K14/525 , A61K39/00
CPC classification number: C07K16/18 , A61K31/704 , A61K38/191 , A61K38/212 , A61K39/3955 , A61P35/00 , C07K14/525 , C07K14/56 , C07K16/2815 , C07K16/2818 , C07K16/2827 , A61K2039/505 , C07K2317/22 , C07K2317/24 , C07K2317/569 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/02 , C07K2319/30
Abstract: The present invention relates, in part, to chimeric proteins that bind a non-cellular structure and their use as therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the chimeric proteins and their use in the treatment of various diseases.
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公开(公告)号：US11661455B2
公开(公告)日：2023-05-30
申请号：US16075323
申请日：2017-02-06
Applicant: Orionis Biosciences BV , VIB VZW , Universiteit Gent
Inventor： Jan Tavernier , Nikolai Kley
CPC classification number: C07K16/2827 , A61P35/00 , A61K2039/505 , C07K2317/24 , C07K2317/569 , C07K2317/622
Abstract: The present invention relates, in part, to chimeric proteins that find use in various immunotherapies. Particularly, the present invention provides targeted therapeutic agents that modulate the immune system for the treatment of diseases such as cancer.
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公开(公告)号：US11384154B2
公开(公告)日：2022-07-12
申请号：US16483114
申请日：2018-02-05
Applicant: Orionis Biosciences BV , VIB VZW , Universiteit Gent
Inventor： Nikolai Kley , Jan Tavernier
Abstract: The present invention relates, in part, to chimeric proteins comprising at least one targeting moiety that recognizes and binds SIRP1α and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the chimeric proteins and their use in the treatment of various diseases.
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Patent Agency Ranking
公开(公告)号：US11001631B2
公开(公告)日：2021-05-11
申请号：US16075318
申请日：2017-02-06
Applicant: Orionis Biosciences BV , VIB VZW , Universiteit Gent
Inventor： Jan Tavernier , Nikolai Kley , Anje Cauwels , Sarah Gerlo
IPC: C07K16/28 , C07K14/715 , C07K16/24 , A61K38/00 , A61K39/395 , C07K16/00 , C07K14/56 , A61P35/00 , A61K39/00
Abstract: The present invention relates, in part, to agents that bind Clec9A and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the Clec9A binding agents and their use in the treatment of various diseases.
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公开(公告)号：US11236166B2
公开(公告)日：2022-02-01
申请号：US16075317
申请日：2017-02-06
Applicant: Orionis Biosciences BV , VIB VZW , Universiteit Gent
Inventor： Nikolai Kley , Jan Tavernier , Anje Cauwels , Sarah Gerlo
IPC: C07K16/28 , C07K14/715 , C07K16/24 , A61K38/00 , A61K39/395 , C07K16/00 , C07K14/56 , A61P35/00 , A61K39/00
Abstract: The present invention relates, in part, to agents that bind CD8 and their use as therapeutic and diagnostic agents. The present invention further relates to pharmaceutical compositions comprising the CD8 binding agents and their use in the treatment of various diseases, including, for example, cancers.
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公开(公告)号：US11236141B2
公开(公告)日：2022-02-01
申请号：US16301304
申请日：2017-05-12
Applicant: Orionis Biosciences BV , VIB VZW , Universiteit Gent
Inventor： Nikolai Kley , Jan Tavernier , Frank Peelman
Abstract: The present invention relates, in part, to chimeric proteins comprising mutant interferon-β and their use as therapeutic agents.
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公开(公告)号：US11084859B2
公开(公告)日：2021-08-10
申请号：US16344668
申请日：2017-10-24
Applicant: Orionis Biosciences NV , VIB VZW , Universiteit Gent
Inventor： Nikolai Kley , Jan Tavernier , Frank Peelman , Lennart Zabeau
Abstract: The present invention relates, in part, to chimeric proteins comprising mutant interferon-γ and their use as therapeutic agents.
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公开(公告)号：US10988538B2
公开(公告)日：2021-04-27
申请号：US16075312
申请日：2017-02-06
Applicant: Orionis Biosciences BV , VIB VZW , Universiteit Gent
Inventor： Nikolai Kley , Jan Tavernier , Sandra Van Lint , Anje Cauwels
IPC: C07K16/28 , C07K14/715 , C07K16/24 , A61K38/00 , A61K39/395 , C07K16/00 , C07K14/56 , A61P35/00 , A61K39/00
Abstract: The present invention relates, in part, to bispecific chimeric proteins that find use in various immunotherapies based on various properties, including, for example, a dual immune cell recruitment and immune signal delivery function.
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