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公开(公告)号：US11623198B2
公开(公告)日：2023-04-11
申请号：US16627086
申请日：2018-04-19
发明人： Yuji Goto , Hirotsugu Ogi , Masatomo So , Kensuke Ikenaka , Hideki Mochizuki , Shinichi Hashimoto
摘要： An ultrasound generation member according to an aspect of the present invention includes an ultrasound generation element configured to emit ultrasound in a direction of a target object in one specific container of a plurality of containers. An ultrasound emission device according to an aspect of the present invention includes the ultrasound generation member, and a drive power supply configured to apply voltage across the ultrasound generation element of the ultrasound generation member. An ultrasound emission device according to an aspect of the present invention includes the ultrasound generation member that includes, as the ultrasound generation element, a plurality of ultrasound generation elements, and a drive power supply configured to apply voltage across the plurality of ultrasound generation elements of the ultrasound generation member.
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2.发明授权公开(公告)号：US12099070B2
公开(公告)日：2024-09-24
申请号：US17425197
申请日：2020-02-03
申请人： Osaka University
发明人： Kensuke Ikenaka , Hideki Mochizuki , Cesar Aguirre Martinez , Yuji Goto , Masatomo So , Keita Kakuda , Hirotsugu Ogi , Kentaro Noi
CPC分类号： G01N33/6896 , G01N33/582 , G01N33/6845 , G01N2333/47 , G01N2800/2835
摘要： A method for discriminating between Parkinson's disease and multiple system atrophy, the method comprising the steps of: (1) preparing a solution containing α-synuclein monomers having a tendency to produce rod-like aggregates and/or a solution containing α-synuclein monomers having a tendency to produce twisted aggregates; (2) adding a biological sample from a subject to the solution(s) containing the α-synuclein monomers prepared in step (1); (3) allowing the α-synuclein monomers to aggregate in the solution(s) obtained in step (2); and (4) detecting α-synuclein aggregates formed in step (3).
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3.发明申请公开(公告)号：US20220128576A1
公开(公告)日：2022-04-28
申请号：US17425197
申请日：2020-02-03
申请人： Osaka University
发明人： Kensuke Ikenaka , Hideki Mochizuki , Cesar Aguirre Martinez , Yuji Goto , Masatomo So , Keita Kakuda , Hirotsugu Ogi , Kentaro Noi
摘要： A method for discriminating between Parkinson's disease and multiple system atrophy, the method comprising the steps of: (1) preparing a solution containing α-synuclein monomers having a tendency to produce rod-like aggregates and/or a solution containing α-synuclein monomers having a tendency to produce twisted aggregates; (2) adding a biological sample from a subject to the solution(s) containing the α-synuclein monomers prepared in step (1); (3) allowing the α-synuclein monomers to aggregate in the solution(s) obtained in step (2); and (4) detecting α-synuclein aggregates formed in step (3).
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