公开(公告)号：US11623198B2

公开(公告)日：2023-04-11

申请号：US16627086

申请日：2018-04-19

申请人： OSAKA UNIVERSITY ,  CORONA ELECTRIC Co., Ltd.

发明人： Yuji Goto ,  Hirotsugu Ogi ,  Masatomo So ,  Kensuke Ikenaka ,  Hideki Mochizuki ,  Shinichi Hashimoto

IPC分类号： B01J19/10 ,  G01N1/38 ,  H01L41/00 ,  B06B1/02

摘要： An ultrasound generation member according to an aspect of the present invention includes an ultrasound generation element configured to emit ultrasound in a direction of a target object in one specific container of a plurality of containers. An ultrasound emission device according to an aspect of the present invention includes the ultrasound generation member, and a drive power supply configured to apply voltage across the ultrasound generation element of the ultrasound generation member. An ultrasound emission device according to an aspect of the present invention includes the ultrasound generation member that includes, as the ultrasound generation element, a plurality of ultrasound generation elements, and a drive power supply configured to apply voltage across the plurality of ultrasound generation elements of the ultrasound generation member.

公开(公告)号：US11965857B2

公开(公告)日：2024-04-23

申请号：US17222324

申请日：2021-04-05

申请人： KANEKA CORPORATION ,  OSAKA UNIVERSITY

发明人： Kensuke Murashima ,  Mutsuaki Murakami ,  Hirotsugu Ogi ,  Koichi Kusakabe

IPC分类号： G01N29/00 ,  G01N29/12 ,  G01N29/24 ,  G01N33/48 ,  G01N33/483

CPC分类号： G01N29/12 ,  G01N29/2418 ,  G01N33/483 ,  G01N2291/0256

摘要： A vibrator that is capable of vibrating without using an electrode and has good detection sensitivity is provided. A carbon-based material vibrator for vibration by light irradiation has a biological substance or a substance capable of identifying a biological substance immobilized on the vibrator. The vibrator may not include a counter electrode for applying a voltage to the vibrator. The carbon-based material may be graphite. A thermal conductivity λ1 in a plane direction of the carbon-based material is 100 times or more than a thermal conductivity λ2 in a thickness direction of the carbon-based material.

公开(公告)号：US11313716B2

公开(公告)日：2022-04-26

申请号：US16635753

申请日：2018-06-21

申请人： OSAKA UNIVERSITY

发明人： Hirotsugu Ogi ,  Tomoyuki Nonaka ,  Fumihito Kato

IPC分类号： G01H11/08 ,  G01H13/00 ,  H01L41/313 ,  H01L41/332 ,  H01L41/337 ,  B81B3/00 ,  G01N29/02 ,  G01N5/02

摘要： A vibration detection element includes substrates, support members, and an oscillator, and may be used as a biosensor and/or for liquid inspection by analysis of oscillator resonant frequency change. The substrates have a space portion, and the support members protrude from the surfaces of the respective substrates into the space portion. The oscillator is disposed between the support members and is capable of vibrating in the space portion. The support members may each include multiple supports which prevent the oscillator from contacting the substrate surfaces. During manufacturing the oscillator may be transferred from the support member of a glass flow path substrate to a silicon flow path substrate by placement of the silicon substrate support member against the oscillator and subsequent removal of the adhesive from the glass substrate support member.

公开(公告)号：US12099070B2

公开(公告)日：2024-09-24

申请号：US17425197

申请日：2020-02-03

申请人： Osaka University

发明人： Kensuke Ikenaka ,  Hideki Mochizuki ,  Cesar Aguirre Martinez ,  Yuji Goto ,  Masatomo So ,  Keita Kakuda ,  Hirotsugu Ogi ,  Kentaro Noi

IPC分类号： G01N33/68 ,  G01N33/58

CPC分类号： G01N33/6896 ,  G01N33/582 ,  G01N33/6845 ,  G01N2333/47 ,  G01N2800/2835

摘要： A method for discriminating between Parkinson's disease and multiple system atrophy, the method comprising the steps of: (1) preparing a solution containing α-synuclein monomers having a tendency to produce rod-like aggregates and/or a solution containing α-synuclein monomers having a tendency to produce twisted aggregates; (2) adding a biological sample from a subject to the solution(s) containing the α-synuclein monomers prepared in step (1); (3) allowing the α-synuclein monomers to aggregate in the solution(s) obtained in step (2); and (4) detecting α-synuclein aggregates formed in step (3).

公开(公告)号：US20220128576A1

公开(公告)日：2022-04-28

申请号：US17425197

申请日：2020-02-03

申请人： Osaka University

发明人： Kensuke Ikenaka ,  Hideki Mochizuki ,  Cesar Aguirre Martinez ,  Yuji Goto ,  Masatomo So ,  Keita Kakuda ,  Hirotsugu Ogi ,  Kentaro Noi

IPC分类号： G01N33/68 ,  G01N33/58

摘要： A method for discriminating between Parkinson's disease and multiple system atrophy, the method comprising the steps of: (1) preparing a solution containing α-synuclein monomers having a tendency to produce rod-like aggregates and/or a solution containing α-synuclein monomers having a tendency to produce twisted aggregates; (2) adding a biological sample from a subject to the solution(s) containing the α-synuclein monomers prepared in step (1); (3) allowing the α-synuclein monomers to aggregate in the solution(s) obtained in step (2); and (4) detecting α-synuclein aggregates formed in step (3).

公开(公告)号：US20210223212A1

公开(公告)日：2021-07-22

申请号：US17222324

申请日：2021-04-05

申请人： KANEKA CORPORATION ,  OSAKA UNIVERSITY

发明人： Kensuke Murashima ,  Mutsuaki Murakami ,  Hirotsugu Ogi ,  Koichi Kusakabe

IPC分类号： G01N29/12 ,  G01N33/483 ,  G01N29/24

摘要： A vibrator that is capable of vibrating without using an electrode and has good detection sensitivity is provided. A carbon-based material vibrator for vibration by light irradiation has a biological substance or a substance capable of identifying a biological substance immobilized on the vibrator. The vibrator may not include a counter electrode for applying a voltage to the vibrator. The carbon-based material may be graphite. A thermal conductivity λ1 in a plane direction of the carbon-based material is 100 times or more than a thermal conductivity λ2 in a thickness direction of the carbon-based material.