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公开(公告)号：US20050037347A1
公开(公告)日：2005-02-17
申请号：US10451000
申请日：2001-12-21
IPC分类号： A61P13/08 , A61P15/00 , A61P35/00 , C07K14/47 , C12N15/12 , C12Q1/68 , C07H21/04 , C07K14/72 , C07K16/30 , G01N33/574
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide consisting of an amino acid sequence which is identical or substantially identical with an amino acid sequence represented by SEQ ID No. 1 or No. 2, (b) a polypeptide consisting of an amino acid sequence represented by SEQ ID No. 1 or No. 2 in which part of amino acids are deleted, substituted or added, and having substantially the same biological activity as the function of the polypeptide (a). The present invention is further related to an antibody binding to the polypeptide or protein, an anti-cancer agent comprising the antibody, a method of screening a substance that binds to the protein or a peptide fragment thereof, and a polynucleotide having at least 15 bases and hybridizing with the DNA according to the present invention under stringent conditions, and a method of detecting cancer with the use of said polynucleotide. The DNA according to the present invention is a cancer-associated gene, and that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译： 本发明涉及包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）由与SEQ ID NO：1所示氨基酸序列相同或基本相同的氨基酸序列组成的多肽 1或2，（b）由SEQ ID No.1或No.2所示的氨基酸序列组成的多肽，其中部分氨基酸被缺失，取代或添加并且具有基本上相同的生物活性 作为多肽（a）的功能。 本发明还涉及与多肽或蛋白质结合的抗体，包含抗体的抗癌剂，筛选与蛋白质结合的物质或其肽片段的方法，以及具有至少15个碱基的多核苷酸 并且在严格条件下与根据本发明的DNA杂交，以及使用所述多核苷酸检测癌症的方法。 根据本发明的DNA是癌相关基因，并且可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
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公开(公告)号：US08008437B2
公开(公告)日：2011-08-30
申请号：US12099513
申请日：2008-04-08
IPC分类号： C07K5/00
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding a polypeptide represented by SEQ ID NO:1 or SEQ ID NO:2. The DNA according to the present invention is highly expressed in prostatic adenocarcinoma and ovarian carcinoma, and is a cancer-associated gene, so that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译： 本发明涉及包含编码由SEQ ID NO：1或SEQ ID NO：2表示的多肽的核苷酸序列的DNA。 根据本发明的DNA在前列腺腺癌和卵巢癌中高度表达，并且是癌相关基因，使得可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
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公开(公告)号：US20080262202A1
公开(公告)日：2008-10-23
申请号：US12099513
申请日：2008-04-08
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding a polypeptide represented by SEQ ID NO:1 or SEQ ID NO:2. The DNA according to the present invention is highly expressed in prostatic adenocarcinoma and ovarian carcinoma, and is a cancer-associated gene, so that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译： 本发明涉及包含编码由SEQ ID NO：1或SEQ ID NO：2表示的多肽的核苷酸序列的DNA。 根据本发明的DNA在前列腺腺癌和卵巢癌中高度表达，并且是癌相关基因，使得可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
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公开(公告)号：US07375199B2
公开(公告)日：2008-05-20
申请号：US10451000
申请日：2001-12-21
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention is related to a DNA comprising a nucleotide sequence encoding a polypeptide represented by SEQ ID NO:1 or SEQ ID NO:2. The DNA according to the present invention is highly expressed in prostatic adenocarcinoma and ovarian carcinoma, and is a cancer-associated gene, so that it is possible to inhibit cancer by blocking the binding of the present protein to its ligand. Accordingly, the present antibody is used not only in the detection of the present protein, but also as an agent for the treatment or prevention of cancers such as prostatic adenocarcinoma and ovarian carcinoma.
摘要翻译： 本发明涉及包含编码由SEQ ID NO：1或SEQ ID NO：2表示的多肽的核苷酸序列的DNA。 根据本发明的DNA在前列腺腺癌和卵巢癌中高度表达，并且是癌相关基因，使得可以通过阻断本发明蛋白质与其配体的结合来抑制癌症。 因此，本发明的抗体不仅用于检测本发明的蛋白质，而且用作治疗或预防前列腺腺癌和卵巢癌等癌症的药剂。
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5.发明申请Method of efficiently recombining orf encoded by cdna and template vector, trap vector and primer to be used therein 审中-公开由cdna和模板载体有效重组或编码的方法，其中使用的捕获载体和引物公开(公告)号：US20050106719A1
公开(公告)日：2005-05-19
申请号：US10491192
申请日：2003-12-04
申请人： Takahiro Nagase , Daisuke Nakajima , Osamu Ohara
发明人： Takahiro Nagase , Daisuke Nakajima , Osamu Ohara
摘要： The object of the present invention is to solve the problems in excising a DNA region (or gene) with conventional restriction enzymes, or in amplification of the DNA region by PCR. The present invention provides a method for precisely, quickly and simply cloning a target ORF, for example the target ORF encoding a protein, particularly the target ORF encoding a long-chain ORF comprising bases as many as several thousand bp in cDNA, and means such as various vectors used for the cloning method,
摘要翻译： 本发明的目的是解决用常规限制酶切除DNA区域（或基因）或通过PCR扩增DNA区域的问题。 本发明提供了精确，快速和简单地克隆靶ORF的方法，例如编码蛋白质的靶ORF，特别是编码包含cDNA多达数千bp的碱基的长链ORF的靶ORF， 作为用于克隆方法的各种载体，
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公开(公告)号：US20060063152A1
公开(公告)日：2006-03-23
申请号：US10204639
申请日：2001-12-20
申请人： Osamu Ohara , Takahiro Nagase , Daisuke Nakajima
发明人： Osamu Ohara , Takahiro Nagase , Daisuke Nakajima
CPC分类号： C07K14/47 , A61K2039/505
摘要： Novel DNAs containing the regions which encode proteins have been directly cloned from cDNA libraries derived from the human adult whole brain, the human adult hippocampus and the human embryonic whole brain, the nucleotide sequences thereof have been determined, and their functions have been identified. The present invention provides DNA which comprises the nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide comprising an amino acid sequence which is identical or substantially identical to an amino acid sequence represented by any one of SEQ ID NOS: 1 to 70; (b) a polypeptide comprising an amino acid sequence derived from the amino acid sequence represented by any one of SEQ ID NOS: 1 to 70 by deletion, substitution or addition of a section of amino acids, and having biological activity which is substantially the same characteristic with the function of the polypeptide of (a); a recombinant polypeptide, which is encoded by the above DNA; and a protein containing the polypeptide.
摘要翻译： 含有编码蛋白质的区域的新DNA已经从源自人成年全脑，人成年海马和人胚胎全脑的cDNA文库直接克隆，其核苷酸序列已被确定，其功能已被鉴定。 本发明提供包含编码以下多肽（a）或（b）的核苷酸序列的DNA：（a）包含与SEQ ID NO：1中任一项所示的氨基酸序列相同或基本相同的氨基酸序列的多肽 NOS：1〜70; （b）通过缺失，取代或添加一部分氨基酸，并且具有基本相同的生物活性的多肽，其包含衍生自SEQ ID NO：1至70中任一个所示氨基酸序列的氨基酸序列的多肽 具有（a）的多肽的功能的特征; 由上述DNA编码的重组多肽; 和含有多肽的蛋白质。
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公开(公告)号：US20120219804A1
公开(公告)日：2012-08-30
申请号：US13037119
申请日：2011-02-28
申请人： Kazuho Uchida , Tsutomu Ando , Daisuke Nakajima , Jiong Liu , Ken Eberts
发明人： Kazuho Uchida , Tsutomu Ando , Daisuke Nakajima , Jiong Liu , Ken Eberts
CPC分类号： C08J7/042 , C08J2369/00 , C08J2433/00 , C08J2483/04 , Y10T428/31511
摘要： A layered body (1) is provided in which a first layer (3) is deposited at one side on at least one surface of a resin substrate (2), a second layer (4) is deposited on the other side of the first layer (3) opposite to the one side thereof at which the first layer (3) is deposited on the resin substrate (2), the first layer (3) is a first organic-inorganic hybrid layer containing a (meth)acrylic resin and a silane compound, and the second layer (4) is a second organic-inorganic hybrid layer obtained by curing a composition made of a solution obtained by hydrolysis and condensation using a composition which contains a silane compound (A) containing at least one epoxy group and represented by the following Formula (1), an aluminum alkoxide (B) represented by the following Formula (2) and a tetrafunctional silane compound (C) represented by the following Formula (3): Si(R1)p(OR2)4-p Formula (1); Al(OR3)3 Formula (2); and Si(OR4)4 Formula (3).
摘要翻译： 提供层叠体（1），其中在树脂基板（2）的至少一个表面上的一侧上沉积第一层（3），在第一层的另一侧上沉积第二层（4） （3）与第一层（3）沉积在树脂基板（2）上的一侧相对的第一层（3）是含有（甲基）丙烯酸树脂的第一有机 - 无机混合层和 硅烷化合物，第二层（4）是通过使用含有含有至少一个环氧基的硅烷化合物（A）的组合物固化由通过水解和缩合获得的溶液制成的组合物而获得的第二有机 - 无机混合层，以及 由下式（1）表示的由下式（2）表示的烷氧基铝（B）和由下式（3）表示的四官能性硅烷化合物（C）表示：Si（R 1）p（OR 2）4 - p式（1）; Al（OR3）3式（2）; 和Si（OR 4）4式（3）。
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公开(公告)号：US07829810B2
公开(公告)日：2010-11-09
申请号：US12078104
申请日：2008-03-27
申请人： Daisuke Nakajima
发明人： Daisuke Nakajima
CPC分类号： H01H13/705 , H01H2209/07 , H01H2209/074 , H01H2221/004 , H01H2221/08
摘要： The present invention provides a pushbutton switch cover sheet formed by using a thin metal plate, in which damage or deformation, such as bending or denting, of the thin metal plate is prevented, thereby making it possible to continuously maintain a satisfactory design. The pushbutton switch cover sheet comprising: a plurality of display portions; a plurality of depressing-operation portions for effecting key input on the display portions, respectively; a base sheet formed of a rubber-like elastic material; and a thin metal plate provided on the base sheet, wherein a reinforcing member formed of a polymeric material is provided for each depressing-operation portion so as to be adjacent to the thin metal plate in a direction of a thickness of the thin metal plate.
摘要翻译： 本发明提供一种通过使用薄金属板形成的按钮开关盖板，其中防止了薄金属板的损伤或变形，例如弯曲或凹陷，从而使得可以连续地保持令人满意的设计。 所述按钮开关盖板包括：多个显示部分; 多个按压操作部分，用于分别在显示部分上进行键输入; 由橡胶状弹性材料形成的基片; 以及设置在基片上的薄金属板，其中，在每个按压操作部分上设置由聚合物材料形成的加强件，以便在薄金属板的厚度方向上与薄金属板相邻。
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9.发明授权Pneumatic radial tire with polyethylene terephthalate cord belt reinforcing layer 有权带聚对苯二甲酸乙二醇酯帘线带增强层的气动子午线轮胎公开(公告)号：US07584774B2
公开(公告)日：2009-09-08
申请号：US10574618
申请日：2004-10-01
申请人： Daisuke Nakajima
发明人： Daisuke Nakajima
CPC分类号： B60C9/22 , C08G2380/00 , Y10T152/10783
摘要： This invention relates to a pneumatic radial tire having low road noise and flat spot and a high high-speed durability, and more particularly to a pneumatic radial tire comprising a radial carcass (5), a belt (6) disposed outside a crown portion of the carcass in a radial direction and comprised of at least two belt layers, and a belt reinforcing layer (7A, 7B) disposed outside the belt in the radial direction, characterized in that the belt reinforcing layer 7A, 7B is formed by continuously and spirally winding a polyethylene terephthalate cord(s) in a circumferential direction of the tire, and this cord has an elastic modulus of not less than 2.5 mN/dtex·% under a load of 29.4 N measured at 160° C.
摘要翻译： 本发明涉及一种具有低道路噪声和平坦点以及高高速耐久性的充气子午线轮胎，更具体地说，涉及一种充气子午线轮胎，其包括径向胎体（5），带（6） 所述胎体沿径向形成并且包括至少两个带束层，以及沿径向设置在所述带外侧的带束层增强层（7A，7B），其特征在于，所述带束层增强层7A，7B通过连续和螺旋形成 在轮胎的圆周方向上缠绕聚对苯二甲酸乙二醇酯帘线，并且在160℃下测量的29.4N的负荷下，该绳的弹性模量不小于2.5mN / dtex。％。
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公开(公告)号：US20080185274A1
公开(公告)日：2008-08-07
申请号：US12078108
申请日：2008-03-27
申请人： Daisuke Nakajima
发明人： Daisuke Nakajima
IPC分类号： H01H13/04
CPC分类号： H01H13/705 , H01H2209/07 , H01H2209/074 , H01H2221/004 , H01H2221/08
摘要： The present invention provides a pushbutton switch cover sheet formed by using a thin metal plate, in which damage or deformation, such as bending or denting, of the thin metal plate is prevented, thereby making it possible to continuously maintain a satisfactory design. The pushbutton switch cover sheet comprising: a plurality of display portions; a plurality of depressing-operation portions for effecting key input on the display portions, respectively; a base sheet formed of a rubber-like elastic material; and a thin metal plate provided on the base sheet, wherein a reinforcing member formed of a polymeric material is provided for each depressing-operation portion so as to be adjacent to the thin metal plate in a direction of a thickness of the thin metal plate.
摘要翻译： 本发明提供一种通过使用薄金属板形成的按钮开关盖板，其中防止了薄金属板的损伤或变形，例如弯曲或凹陷，从而使得可以连续地保持令人满意的设计。 所述按钮开关盖板包括：多个显示部分; 多个按压操作部分，用于分别在显示部分上进行键输入; 由橡胶状弹性材料形成的基片; 以及设置在基片上的薄金属板，其中，在每个按压操作部分上设置由聚合物材料形成的加强件，以便在薄金属板的厚度方向上与薄金属板相邻。
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