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    Process for the preparation of substituted acetic acids and derivatives thereof
    1.
    发明授权
    Process for the preparation of substituted acetic acids and derivatives thereof 失效
    取代乙酸及其衍生物的制备方法

    公开(公告)号：US4417073A

    公开(公告)日：1983-11-22

    申请号：US324929

    申请日：1981-11-25

    申请人： Otto Ackermann ,  Gerhard Daum

    发明人： Otto Ackermann ,  Gerhard Daum

    IPC分类号： C07C69/22 ,  B01J21/00 ,  B01J21/12 ,  B01J23/00 ,  C07B61/00 ,  C07C51/00 ,  C07C51/38 ,  C07C53/122 ,  C07C53/124 ,  C07C53/126 ,  C07C53/128 ,  C07C57/30 ,  C07C59/64 ,  C07C67/00 ,  C07C67/32 ,  C07C69/24 ,  C07C69/612 ,  C07C69/614 ,  C07C69/736 ,  C07C253/00 ,  C07C253/30 ,  C07C255/03 ,  C07C255/33 ,  C07C255/37 ,  C07C69/76

    CPC分类号： C07C253/30 ,  C07C51/38

    摘要： A process for the preparation of substituted acetic acids and derivatives thereof, having the formula ##STR1## wherein X is --COOH, --COOY or --CN,Y is --CH.sub.3 or --C.sub.2 H.sub.5,R.sub.1 is a saturated, branched or unbranched aliphatic radical having from 1 to 6 carbon atoms, a phenyl radical, or a phenyl radical substituted by alkyl or alkoxy groups, andR.sub.2 is hydrogen or a saturated, branched or unbranched aliphatic radical having from 1 to 6 carbon atoms, a phenyl radical, or a phenyl radical substituted by alkyl or alkoxy groups,wherein R.sub.1 and R.sub.2 may be the same or different which process comprises converting the corresponding malonic or cyanoacetic ester of the formula ##STR2## wherein Z is --COOY or --CN, andY, R.sub.1 and R.sub.2 are identified as above at elevated temperature in the presence of a catalyst, e.g., a catalyst containing from about 50 to 75 weight percent SiO.sub.2 and from 15 to 19 weight percent Al.sub.2 O.sub.3 and exhibit ignition losses ranging from 15 to 20 weight percent.

    摘要翻译： 具有式（I）的取代的乙酸及其衍生物的方法，其中X是-COOH，-COOY或-CN，Y是-CH 3或-C 2 H 5，R 1是饱和的，支链的或未分支的 具有1至6个碳原子的脂族基团，苯基或被烷基或烷氧基取代的苯基，R 2是氢或具有1至6个碳原子的饱和，支链或非支链脂族基团，苯基， 或被烷基或烷氧基取代的苯基，其中R 1和R 2可以相同或不同，该方法包括将其中Z为-COOY或-CN的式Ⅹ（II）的相应的丙二酸或氰基乙酸酯转化为 Y，R1和R2如上所述在升高的温度下在催化剂存在下进行鉴定，例如含有约50-75％（重量）SiO 2和15- 19％（重量）Al 2 O 3的催化剂，并显示出15至20重量％的点火损失 百分。

    Process for the preparation of pyridylamino-methylenemalonic acid derivatives
    2.
    发明授权
    Process for the preparation of pyridylamino-methylenemalonic acid derivatives 失效
    吡啶氨基甲基亚胺酸衍生物的制备方法

    公开(公告)号：US4013656A

    公开(公告)日：1977-03-22

    申请号：US625287

    申请日：1975-10-23

    申请人： Otto Ackermann ,  Otto Bleh, deceased ,  Dieter Morgenstern

    发明人： Otto Ackermann ,  Otto Bleh, deceased ,  Dieter Morgenstern

    IPC分类号： C07D213/74 ,  C07D213/57 ,  C07D213/55

    CPC分类号： C07D213/74

    摘要： A process for preparing a pyridylaminomethylenemalonic acid derivative of the formula: ##STR1## which comprises reacting together a pyridyl compound of the formula: ##STR2## an alkoxy compound of the formula: ##STR3## and a malonic acid derivative of the formula selected of the group of ##STR4## wherein: R.sub.5 and R.sub.7 are the groups -- OOR.sub.4 or OOR.sub.5 or .tbd.NR is a substituted or unsubstituted alkyl radical, preferably a C.sub.1 - C.sub.4 alkyl radical;R.sub.1, r.sub.2 and R.sub.3 are each independently substituted or unsubstituted alkyl radicals, preferably C.sub.1 - C.sub.2 alkyl radicals;R.sub.4 and R.sub.5 are each independently substituted or unsubstituted alkyl radicals, preferably C.sub.1 - C.sub.8 alkyl radicalsAt a temperature of 60.degree. to 160.degree. C.

    Process of performing cyclization reactions using benzyl or pyridylamino malonic acid derivatives
    6.
    发明授权
    Process of performing cyclization reactions using benzyl or pyridylamino malonic acid derivatives 失效
    使用苄基或吡啶基氨基丙二酸衍生物进行环化反应的方法

    公开(公告)号：US4079058A

    公开(公告)日：1978-03-14

    申请号：US728812

    申请日：1976-10-01

    申请人： Otto Ackermann ,  Karl-Theo VON Meszoly ,  Arnold Lenz

    发明人： Otto Ackermann ,  Karl-Theo VON Meszoly ,  Arnold Lenz

    IPC分类号： C07D215/56 ,  C07D471/04 ,  C07D491/056

    CPC分类号： C07D471/04 ,  C07D215/56

    摘要： Process of producing a naphthyridine or quinoline compound of the formula: ##STR1## wherein R.sub.2, R.sub.3, R.sub.4, and R.sub.6 can be alkyl, and R.sub.1 is nitrogen or CH. The corresponding pyridyl- or phenylaminomethylenemalonic acid diester is cyclized to yield said compound and an alcohol. The malonic acid diester at below reaction temperature is added to a solvent, e.g., diphenyl benzene, at above reaction temperature in proportion so that the mixture attains reaction temperature. Good yields at high throughputs are achieved.

    摘要翻译： 制备下式的萘啶或喹啉化合物的方法：其中R 2，R 3，R 4和R 6可以是烷基，R 1是氮或CH。 将相应的吡啶基或苯基氨基亚甲基丙二酸二酯环化，得到所述化合物和醇。 在低于反应温度的丙二酸二酯以比例的高于反应温度的溶剂例如二苯基苯中加入，使混合物达到反应温度。 实现高产量的良好产率。

    Method of preparing alkoxymethylenemalonic acid esters
    7.
    发明授权
    Method of preparing alkoxymethylenemalonic acid esters 失效
    制备烷氧基亚甲基丙二酸酯的方法

    公开(公告)号：US4058553A

    公开(公告)日：1977-11-15

    申请号：US582474

    申请日：1975-05-30

    申请人： Otto Ackermann ,  Otto Bleh, deceased ,  Walter Rogler

    发明人： Otto Ackermann ,  Otto Bleh, deceased ,  Walter Rogler

    IPC分类号： C07C69/708 ,  C07C69/66

    CPC分类号： C07C69/708

    摘要： Preparation of alkoxymethylene malonic acid ester of formula: ##STR1## wherein R and each R' is an alkyl group, by reaction of malonic acid diester and ortho formic acid triester. The reaction is performed in the presence of a carboxylic acid or a carboxylic acid anhydride and a Lewis acid. The ortho ester is initially present in amount of at least 1,4 mols per mole of the malonic acid ester starting material. Alcohol formed during the reaction is removed during the reaction.

    摘要翻译： 制备式：其中R和每个R'是烷基，通过丙二酸二异构体和邻甲酸三酯的反应制得。 反应在羧酸或羧酸酐和路易斯酸存在下进行。 原始酯最初以每摩尔丙二酸酯起始材料至少为1,4摩尔的量存在。 反应期间形成的醇在反应期间被除去。