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公开(公告)号：US20230084931A1
公开(公告)日：2023-03-16
申请号：US17817065
申请日：2022-08-03
发明人： James Anthony Clarke , James White , Richard Muscat , Jessica Mary May Knott , Ramiz Iqbal Nathani , Andrew John Heron , Mark John Bruce , Lakmal Jayasinghe , Domenico Caprotti , David Jackson Stoddart , Rebecca Victoria Bowen , Christopher James Wright , Paul Richard Moody
IPC分类号： C12Q1/6869 , G01N33/487
摘要： Methods of characterizing an analyte using a nanopore. One aspect features methods for characterizing a double-stranded polynucleotide using a nanopore, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.
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公开(公告)号：US11920193B2
公开(公告)日：2024-03-05
申请号：US16972039
申请日：2019-06-06
发明人： James Anthony Clarke , James White , Richard Muscat , Jessica Mary May Johnson , Ramiz Iqbal Nathani , Andrew John Heron , Mark John Bruce , Lakmal Nishantha Jayasinghe , Domenico Caprotti , David Jackson Stoddart , Rebecca Victoria Bowen , Christopher James Wright , Paul Richard Moody
IPC分类号： C12Q1/6869 , G01N33/487
CPC分类号： C12Q1/6869 , G01N33/48721
摘要： Methods of characterizing an analyte using a detector such as a nanopore and an enzyme are provided. One aspect features methods for characterizing a double-stranded polynucleotide using a detector, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.
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公开(公告)号：US11649480B2
公开(公告)日：2023-05-16
申请号：US16304114
申请日：2017-05-25
IPC分类号： C12Q1/6806 , C12Q1/6869
CPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q2521/10 , C12Q2521/513 , C12Q2522/101 , C12Q2525/155 , C12Q2525/191 , C12Q2535/122 , C12Q2565/631 , C12Q1/6869 , C12Q2535/122 , C12Q2565/631 , C12Q1/6806 , C12Q2521/10 , C12Q2521/513 , C12Q2525/155 , C12Q2525/191 , C12Q2522/101
摘要： The invention relates to a method for modifying a template double stranded polynucleotide, especially for characterisation using nanopore sequencing. The method produces from the template a plurality of modified double stranded polynucleotides. These modified polynucleotides can then be characterised.
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公开(公告)号：US11466317B2
公开(公告)日：2022-10-11
申请号：US16465987
申请日：2017-11-29
发明人： James Clarke , James White , Richard Muscat , Jessica Mary May Knott , Ramiz Iqbal Nathani , Andrew John Heron , Mark John Bruce , Lakmal Nishantha Jayasinghe , Domenico Caprotti , David Jackson Stoddart , Rebecca Victoria Bowen , Christopher James Wright , Paul Richard Moody
IPC分类号： C12Q1/6869 , G01N33/487
摘要： Methods of characterizing an analyte using a nanopore. One aspect features methods for characterizing a double-stranded polynucleotide using a nanopore, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.
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公开(公告)号：US20220186274A1
公开(公告)日：2022-06-16
申请号：US17509988
申请日：2021-10-25
IPC分类号： C12P19/34 , C12Q1/6869 , C12N9/12 , C12Q1/68
摘要： The invention relates to a method for modifying a template double stranded polynucleotide, especially for characterisation using nanopore sequencing. The method produces from the template a plurality of modified double stranded polynucleotides. These modified polynucleotides can then be characterised.
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