公开(公告)号：US20240308987A1

公开(公告)日：2024-09-19

申请号：US18665334

申请日：2024-05-15

申请人： SHENZHEN BAY LABORATORY ,  PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOL

发明人： Zhendong ZHU ,  Zhengshuang XU ,  Ting LI ,  Chao CHE ,  Xingye REN ,  Sigui CHEN ,  Jiayin ZHANG ,  Ben ZHANG ,  Qi YANG ,  Chuanbing ZHANG ,  Zhen YANG

IPC分类号： C07D403/14 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/506 ,  A61P35/00 ,  C07D205/04 ,  C07D213/56 ,  C07D213/75 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D409/14 ,  C07D417/14

CPC分类号： C07D403/14 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/506 ,  A61P35/00 ,  C07D205/04 ,  C07D213/56 ,  C07D213/75 ,  C07D401/12 ,  C07D401/14 ,  C07D403/10 ,  C07D409/14 ,  C07D417/14

摘要： A small molecule inhibitor targeting EB virus antigen protein, and/or a pharmaceutical composition comprising same, capable of being used for treating diseases caused by EB virus infection, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus or rheumatoid arthritis, especially nasopharyngeal carcinoma. The present disclosure further provides a small molecule inhibitor against nasopharyngeal carcinoma, and/or a pharmaceutical composition comprising same, capable of being used for treating nasopharyngeal carcinoma.

公开(公告)号：US20180149568A1

公开(公告)日：2018-05-31

申请号：US15579397

申请日：2015-06-05

申请人： PEKING UNIVERSITY

发明人： Li ZHANG ,  Dacheng ZHANG ,  Fang YANG ,  Wei WANG ,  Dayu TIAN ,  Peng LIU ,  Ting LI ,  Kui LUO

IPC分类号： G01N3/307

CPC分类号： G01N3/307 ,  G01N2203/001 ,  G01N2203/0035 ,  G01N2203/0039 ,  G01N2203/0067 ,  G01N2203/0087 ,  G01N2203/0208 ,  G01N2203/0244 ,  G01N2203/0248 ,  G01N2203/0286 ,  G01N2203/0605 ,  G01N2203/0682

摘要： Disclosed is an apparatus for in-situ testing impact strength of a micro-structure, comprising: a flexible beam, one end of which being fixed; an impact mass block disposed at the other end of the flexible beam and configured to exert an impact on the micro-structure; and a locking member comprising a beam arm and a plurality of locking teeth, wherein the beam arm is perpendicular to the flexible beam and one end of the beam arm is fixed, and wherein the plurality of locking teeth are distributed at intervals along the beam arm, such that the other end of the flexible beam is engaged to one of the plurality of locking teeth when the flexible beam is loaded. A method for testing an impact strength of a micro-structure is also disclosed.

公开(公告)号：US20230157996A1

公开(公告)日：2023-05-25

申请号：US18073748

申请日：2022-12-02

申请人： Shenzhen Bay Laboratory ,  Peking University Shenzhen Graduate School

发明人： Zhendong ZHU ,  Zhengshuang XU ,  Ting LI ,  Chao CHE ,  Qingzhou ZHANG ,  Sigui CHEN ,  Huangcan CHEN ,  Dehu XIANG ,  Zhen YANG

IPC分类号： A61K31/4025 ,  A61P31/20

CPC分类号： A61K31/4025 ,  A61P31/20

摘要： The present application provides a small-molecule inhibitor targeting an EB virus nuclear antigen protein, and/or a pharmaceutical composition containing the same, which can be used for the treatment of a disease caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present application further provides a small-molecule inhibitor targeting an EB virus nuclear antigen protein, and/or a pharmaceutical composition containing the same, which can be used for the treatment of a disease caused by EBV infection in a lytic and/or latent phase.