公开(公告)号：US11367603B2

公开(公告)日：2022-06-21

申请号：US16869115

申请日：2020-05-07

Applicant: PERKINELMER HEALTH SCIENCES CANADA INC

Inventor： Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/26 ,  H01J49/04

Abstract: A device for providing analyte to an analyzer is described. In some examples, the device comprises a substrate comprising a plurality of wells formed therein at predetermined locations. Each of the wells can be capable of containing an analyte without mixing with analytes in other of the wells. Each of the wells can also have a well exit to allow analyte to exit therefrom. A channel can be in flow communication with at least one of the well exits, and can guide analyte ions exiting therefrom to the mass analyzer. The wells may be filled prior to use in association with the mass analyzer. The substrate may be used as part of a fraction collector if desired.

公开(公告)号：US10658168B2

公开(公告)日：2020-05-19

申请号：US15970517

申请日：2018-05-03

Applicant: PERKINELMER HEALTH SCIENCES CANADA INC.

Inventor： Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/42 ,  H01J49/16 ,  H01J49/06

Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.

公开(公告)号：US11631578B2

公开(公告)日：2023-04-18

申请号：US17403033

申请日：2021-08-16

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/16 ,  H01J49/42 ,  H01J49/06

Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.

公开(公告)号：US11094520B2

公开(公告)日：2021-08-17

申请号：US16877353

申请日：2020-05-18

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/16 ,  H01J49/42 ,  H01J49/06

Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.

公开(公告)号：US20200350150A1

公开(公告)日：2020-11-05

申请号：US16869115

申请日：2020-05-07

Applicant: PERKINELMER HEALTH SCIENCES CANADA INC

Inventor： Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/04 ,  H01J49/26

Abstract: A device for providing analyte to an analyzer is described. In some examples, the device comprises a substrate comprising a plurality of wells formed therein at predetermined locations. Each of the wells can be capable of containing an analyte without mixing with analytes in other of the wells. Each of the wells can also have a well exit to allow analyte to exit therefrom. A channel can be in flow communication with at least one of the well exits, and can guide analyte ions exiting therefrom to the mass analyzer. The wells may be filled prior to use in association with the mass analyzer. The substrate may be used as part of a fraction collector if desired.

公开(公告)号：US20190341241A1

公开(公告)日：2019-11-07

申请号：US15970517

申请日：2018-05-03

Applicant: Perkinelmer Health Sciences Canada Inc.

Inventor： Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/16 ,  H01J49/06 ,  H01J49/42

Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.