公开(公告)号：US11637005B2

公开(公告)日：2023-04-25

申请号：US17485658

申请日：2021-09-27

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Samad Bazargan ,  Hamid Badiei

IPC: H01J49/00 ,  H01J49/04

Abstract: Certain embodiments described herein are directed to methods and systems of detecting two or more analytes present in a single system such as a nanoparticle or nanostructure. In some examples, the methods and systems can estimate data gaps and fit intensity curves to obtained detection values so the amount of the two or more analytes present in the single system can be quantified.

公开(公告)号：US11367603B2

公开(公告)日：2022-06-21

申请号：US16869115

申请日：2020-05-07

Applicant: PERKINELMER HEALTH SCIENCES CANADA INC

Inventor： Frenny Kaushal ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/26 ,  H01J49/04

Abstract: A device for providing analyte to an analyzer is described. In some examples, the device comprises a substrate comprising a plurality of wells formed therein at predetermined locations. Each of the wells can be capable of containing an analyte without mixing with analytes in other of the wells. Each of the wells can also have a well exit to allow analyte to exit therefrom. A channel can be in flow communication with at least one of the well exits, and can guide analyte ions exiting therefrom to the mass analyzer. The wells may be filled prior to use in association with the mass analyzer. The substrate may be used as part of a fraction collector if desired.

公开(公告)号：US11169024B2

公开(公告)日：2021-11-09

申请号：US16639475

申请日：2018-08-16

Applicant: University of Rochester ,  PerkinElmer Health Sciences Canada, Inc.

Inventor： Jannick Rolland-Thompson ,  Aaron Bauer ,  Dennis Yates ,  Mahsa Farsad

IPC: G01J3/18 ,  G01J3/02 ,  G01J3/28

Abstract: An echelle spectrometer includes a slit opening for incoming light, a collimator which collimates a diverging beam of light generated through the slit, a reflective echelle grating which disperses the collimated light along a first dimension; a cross-disperser which disperses at least a portion of the collimated light in a second dimension orthogonal to the first dimension to create a two-dimensional spectral field-of-view; and an imaging system which images the two-dimensional spectral field-of-view onto a detector; wherein the imaging system comprises primary, secondary, and tertiary tilted mirrors, where each of the tilted mirrors comprises a freeform, rotationally non-symmetric surface shape.

公开(公告)号：US11133161B2

公开(公告)日：2021-09-28

申请号：US16920887

申请日：2020-07-06

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Samad Bazargan ,  Hamid Badiei

IPC: H01J49/00 ,  H01J49/04

Abstract: Certain embodiments described herein are directed to methods and systems of detecting two or more analytes present in a single system such as a nanoparticle or nanostructure. In some examples, the methods and systems can estimate data gaps and fit intensity curves to obtained detection values so the amount of the two or more analytes present in the single system can be quantified.

公开(公告)号：US20210223158A1

公开(公告)日：2021-07-22

申请号：US16629063

申请日：2019-01-15

Applicant: PerkinElmer Health Sciences Canada, Inc.

Inventor： Chady Stephan ,  David Hilligoss

IPC: G01N15/14 ,  G01N21/73 ,  G01N33/28

Abstract: A system and method of using the system for analyzing liquid samples obtain from viscous sources. The system includes a sample delivery system, a particle counter configured to receive a liquid sample from the liquid sample delivery system, a composition analyzer configured to receive the liquid sample from the particle counter, a feed system configured to draw the liquid sample through the particle counter and subsequently inject the liquid sample into the composition analyzer; and a processor to process and analyze data from the particle counter and composition analyzer.

公开(公告)号：US10658167B2

公开(公告)日：2020-05-19

申请号：US16147683

申请日：2018-09-29

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Heather Gamble ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/14 ,  H01J27/20 ,  G01N30/72 ,  H01J49/04

Abstract: An ion source comprising a chamber and an electron collector is described. In one configuration, the chamber comprises a sample inlet and an ion outlet. The chamber may also include an electron inlet configured to receive electrons from an electron source. The electron collector can be arranged in opposition to the electron inlet. The chamber can be configured to direct an electron beam from the electron source along a path with the chamber transverse to a path between the gas inlet and the ion outlet. The chamber may comprise an ion guide that includes a guide axis offset from an axis of the ion outlet.

公开(公告)号：US20190326109A1

公开(公告)日：2019-10-24

申请号：US15958781

申请日：2018-04-20

Applicant: PERKINELMER HEALTH SCIENCES CANADA INC.

Inventor： Heather GAMBLE ,  Gholamreza JAVAHERY ,  Lisa COUSINS ,  Charles JOLLIFFE

IPC: H01J49/14

Abstract: A mass analyzer includes two chambers for ionizing gas to form ions and/or introducing reaction gases to aid in ionization. A first chamber includes an electron to allow electron bombardment of a first gas. A second chamber receives a second gas and ions from the first chamber to allow interaction between the second gas, and the ions from the first chamber. The first and/or second gas may include analyte.

公开(公告)号：US20190221417A1

公开(公告)日：2019-07-18

申请号：US16209140

申请日：2018-12-04

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Chady Stephan ,  Samad Bazargan

IPC: H01J49/10 ,  H01J49/04 ,  G01N30/72 ,  H01J49/16

Abstract: Methods and systems of identifying two or more elements in a single individual particle are described. In some examples, an optical emission from each of an ionized first element and an ionized second element can simultaneously be detected to identify at least a first element in a particle from a plurality of particles using the optical emission from the ionized first element, and to identify at least a second element in the particle from the plurality of particles using the optical emission from the second ionized element. The identified first element and the identified second element can be used to identify a source of the particle from a plurality of particles.

公开(公告)号：US20190189416A1

公开(公告)日：2019-06-20

申请号：US16146752

申请日：2018-09-28

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Chady Stephan ,  Hamid Badiei ,  Serguei Savtchenko ,  Samad Barzagan

IPC: H01J49/10 ,  H01J49/04 ,  G01N30/72 ,  H01J49/16

CPC classification number: H01J49/107 ,  G01N30/7273 ,  H01J49/045 ,  H01J49/049 ,  H01J49/167

Abstract: Devices, systems and methods including a spray chamber are described. In certain examples, the spray chamber may be configured with an outer chamber configured to provide tangential gas flows. In other instances, an inner tube can be positioned within the outer chamber and may comprise a plurality of microchannels. In some examples, the outer chamber may comprise dual gas inlet ports. In some instances, the spray chamber may be configured to provide tangential gas flow and laminar gas flows to prevent droplet formation on surfaces of the spray chamber. Optical emission devices, optical absorption devices and mass spectrometers using the spray chamber are also described.

公开(公告)号：US11581177B2

公开(公告)日：2023-02-14

申请号：US16519925

申请日：2019-07-23

Applicant: PerkinElmer Health Sciences Canada, Inc. ,  Perkin Elmer Yuhan Hoesa

Inventor： Chady Stephan ,  Chung Ryu

IPC: H01J49/04 ,  H01J49/10

Abstract: Systems and methods for use in introducing samples to an analytical instrument. The systems and methods are adaptable to process either a liquid sample or a gaseous sample, including samples containing particle contaminants, for subsequent analysis using an analytical instrument.