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公开(公告)号：US09764040B2
公开(公告)日：2017-09-19
申请号：US15280563
申请日：2016-09-29
Applicant: PFIZER INC.
Inventor： Chakrapani Subramanyam , Frank Erich Koehn , Kenneth John Dirico , Alessandra S. Eustaquio , Michael Eric Green , Haiyin He , Min He , Christopher John O'Donnell , Sujiet Puthenveetil , Anokha Ratnayake , Jesse Alexander Teske , Hui Yu Yang
IPC: A61K38/00 , A61K47/48 , C07D309/10 , C07D405/12 , C07D493/20 , A61K45/06 , C07D309/14 , C07D405/14 , C07D493/10 , A61K31/351 , A61K31/397 , A61K31/453 , A61K31/496 , A61K31/501 , A61K31/35 , A61K31/4025
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
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公开(公告)号：US20160022626A1
公开(公告)日：2016-01-28
申请号：US14818455
申请日：2015-08-05
Applicant: PFIZER INC.
Inventor： Chakrapani SUBRAMANYAM , Frank Erich Koehn , Kenneth John Dirico , Alessandra S. Eustaquio , Michael Eric Green , Haiyin He , Min He , Christopher John O'Donnell , Sujiet Puthenveetil , Anokha Ratnayake , Jesse Alexander Teske , Hui Yu Yang
IPC: A61K31/351 , A61K47/48 , A61K31/496 , A61K31/501 , A61K31/453 , A61K31/397
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
Abstract translation: 本发明涉及新颖的细胞毒素剪接抑制物类似物及其衍生物，其抗体药物偶联物及其用于治疗包括癌症在内的医学病症的方法。
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公开(公告)号：US09504669B2
公开(公告)日：2016-11-29
申请号：US14818455
申请日：2015-08-05
Applicant: PFIZER INC.
Inventor： Chakrapani Subramanyam , Frank Erich Koehn , Kenneth John Dirico , Alessandra S. Eustaquio , Michael Eric Green , Haiyin He , Min He , Christopher John O'Donnell , Sujiet Puthenveetil , Anokha Ratnayake , Jesse Alexander Teske , Hui Yu Yang
IPC: A61K38/00 , A61K31/351 , C07D309/10 , C07D405/12 , C07D493/20 , A61K45/06 , A61K47/48 , C07D309/14 , C07D405/14 , C07D493/10 , A61K31/397 , A61K31/453 , A61K31/496 , A61K31/501
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
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公开(公告)号：US09169264B2
公开(公告)日：2015-10-27
申请号：US14069057
申请日：2013-10-31
Applicant: PFIZER INC.
Inventor： Chakrapani Subramanyam , Frank Erich Koehn , Kenneth John Dirico , Alessandra S. Eustaquio , Michael Eric Green , Haiyin He , Min He , Christopher John O'Donnell , Sujiet Puthenveetil , Anokha Ratnayake , Jesse Alexander Teske , Hui Yu Yang
IPC: A61K38/00 , C07K16/00 , C07D493/10 , C07D309/10 , C07D405/12 , C07D493/20 , A61K45/06 , A61K47/48 , C07D309/14 , C07D405/14
CPC classification number: A61K47/6855 , A61K31/35 , A61K31/351 , A61K31/397 , A61K31/4025 , A61K31/453 , A61K31/496 , A61K31/501 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K47/6889 , C07D309/10 , C07D309/14 , C07D405/12 , C07D405/14 , C07D493/10 , C07D493/20
Abstract: The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
Abstract translation: 本发明涉及新颖的细胞毒素剪接抑制物类似物及其衍生物，其抗体药物偶联物及其用于治疗包括癌症在内的医学病症的方法。
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