公开(公告)号：US20240181028A1

公开(公告)日：2024-06-06

申请号：US18513738

申请日：2023-11-20

Applicant: Pfizer Inc.

Inventor： Catherine Alex ,  Annaliesa Sybil Anderson ,  Bishwa Raj Bhetuwal ,  Zecheng Chen ,  Kaushik Dutta ,  Caitlyn Gallagher ,  Jianxin Gu ,  Isis Kanevsky ,  Jin-Hwan Kim ,  Justin Keith Moran ,  Suddham Singh ,  Naveen Surendran ,  Abhishek Ravindra Vartak ,  YuYing Yang

IPC: A61K39/09 ,  A61K47/64

CPC classification number: A61K39/092 ,  A61K47/646

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in Prevnar, Synflorix and/or Prevnar 13. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions.

公开(公告)号：US12121588B2

公开(公告)日：2024-10-22

申请号：US16480792

申请日：2018-02-01

Applicant: PFIZER INC.

Inventor： Kaushik Dutta ,  Jose Manuel Gomes ,  Frank W. Kotch ,  Vimalkumar B. Patel ,  Amarnauth Shastrie Prashad ,  Renee L. Procopio-Melino ,  Xiaotian Zhong

IPC: A61K47/42 ,  A61K47/50 ,  A61K47/64 ,  A61K47/68 ,  C07B31/00 ,  C07B33/00 ,  C07K1/00 ,  C07K16/30 ,  C07K1/107 ,  C07K1/20

CPC classification number: A61K47/6843 ,  A61K47/6855 ,  A61K47/6889 ,  C07K1/00 ,  C07K16/3015 ,  C07K1/1077 ,  C07K1/20 ,  C07K2317/14

Abstract: Optimizing production of selectively capped, and uncapped, cysteines on antibodies by manipulation of cell growth conditions including the deliberate depletion of cysteine and/or cystine in the cell culture process by way of media components, batch duration, or cell density to achieve efficient production of proteins including antibody-drug-conjugates (ADCs).; conjugating a TNB-capped cysteine-containing protein by reacting it with a reducing agent capable of detaching the TNB-capping moieties from the protein without significantly reducing antibody inter-chain sulfur bonds, and conjugating reduced sulfur bonds on the protein to a payload through a reactive linking moiety.

公开(公告)号：US20240350608A1

公开(公告)日：2024-10-24

申请号：US18634326

申请日：2024-04-12

Applicant: Pfizer Inc.

Inventor： Bishwa Raj Bhetuwal ,  Kaushik Dutta ,  Jianxin Gu ,  Sunayana Kapil ,  Jin-Hwan Kim ,  Justin Keith Moran ,  Suddham Singh ,  YuYing Yang

IPC: A61K39/09 ,  A61K39/00 ,  A61K39/385 ,  A61K47/64

CPC classification number: A61K39/092 ,  A61K47/646 ,  A61K39/385 ,  A61K2039/55516

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

公开(公告)号：US20240325515A1

公开(公告)日：2024-10-03

申请号：US18621962

申请日：2024-03-29

Applicant: Pfizer Inc.

Inventor： Kaushik Dutta ,  Caitlyn Gallagher ,  Isis Kanevsky ,  Jin-hwan Kim ,  Justin Keith Moran ,  Suddham Singh ,  Abhishek Ravindra Vartak

IPC: A61K39/09 ,  A61K39/00 ,  A61K47/42 ,  A61P31/04

CPC classification number: A61K39/092 ,  A61K47/42 ,  A61P31/04 ,  A61K2039/55505

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.

公开(公告)号：US20230405137A1

公开(公告)日：2023-12-21

申请号：US18252124

申请日：2021-11-04

Applicant: Pfizer Inc.

Inventor： Paul Wayne Brown ,  Kaushik Dutta ,  Jason Arnold Lotvin ,  Kelly Jeffrey Sackett

IPC: A61K47/64 ,  A61K39/09 ,  A61P31/04

CPC classification number: A61K47/646 ,  A61K39/092 ,  A61P31/04 ,  A61K2039/6037

Abstract: The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic compositions and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumococcal infections using said novel immunogenic compositions.