公开(公告)号：US09751937B2

公开(公告)日：2017-09-05

申请号：US14626321

申请日：2015-02-19

Applicant: PFIZER INC.

Inventor： Michelle M. Mader ,  James R. Apgar ,  Kevin D. Parris

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/22 ,  A61K45/06 ,  C07K16/00

CPC classification number: C07K16/22 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/622 ,  C07K16/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.

公开(公告)号：US08992913B2

公开(公告)日：2015-03-31

申请号：US13916379

申请日：2013-06-12

Applicant: Pfizer Inc.

Inventor： Michelle M. Mader ,  James R. Apgar ,  Kevin D. Parris

IPC: A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/18 ,  C07K16/22 ,  C12N15/11 ,  C12N15/12 ,  C12N15/13

CPC classification number: C07K16/22 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/622 ,  C07K16/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.

Abstract translation: 本公开提供与先前的抗GDF-8抗体相比，能够在宿主细胞中显着更高水平的表达的改进的中和抗GDF-8抗体。 还提供了使用包含此类抗体的组合物以增加肌肉质量或强度以及治疗或预防肌肉疾病，神经肌肉疾病，代谢障碍，脂肪组织病症或骨骼疾病的方法。