公开(公告)号：US20240382654A1

公开(公告)日：2024-11-21

申请号：US18663594

申请日：2024-05-14

Applicant: POSTECH Research and Business Development Foundation ,  INDUSTRY-ACADEMIC COORPERATION FOUNDATION DAEGU HAANY UNIVERSITY

Inventor： Jae Yun KIM ,  Tugce SEN ,  Jae Yeon LEE ,  Dong-Woo CHO

IPC: A61L27/36 ,  A61L27/54 ,  A61L27/56

Abstract: The present invention relates to a chemical cross-linking based porous material for tissue regeneration and hemostasis, including an extracellular matrix of decellularized kidney tissue, and a method for production thereof. The porous material including an extracellular matrix of decellularized kidney tissues according to the present invention forms a chemical cross-linking bond, while the final product does not contain any existing cross-linking agent component, whereby the porous material can be utilized in biocompatible substances. Further, the porous material of the present invention does not only have rapid hemostasis but also delays degradation in a long term to thus exhibit tissue regeneration effects, so that the porous material is expected to be usefully applicable for treatment of different diseases due to tissue damage in a variety of tissues, or for hemostasis and tissue regeneration at removal of tissues or incision operation.

公开(公告)号：US20230174950A1

公开(公告)日：2023-06-08

申请号：US17995114

申请日：2020-11-24

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

Inventor： Yong Kyun KIM ,  Dong-Woo CHO ,  Sun Ah NAM ,  Jin Won KIM ,  Jae Yeon LEE ,  Jae Yun KIM

IPC: C12N5/071 ,  A61K35/22

CPC classification number: C12N5/0697 ,  A61K35/22 ,  C12N5/0686 ,  C12N2506/45 ,  C12N2513/00 ,  C12N2533/54 ,  C12N2533/90

Abstract: The present invention relates to a kidney organoid having a nephron-like structure and a production method therefor. A kidney organoid culture system using kidney dECM hydrogels according to the present invention induced the vascularization of the kidney organoid and the expression of podocytes, tubular transporters, and cilium genes, and has an effect of forming a more mature nephron-like structure. Therefore, the kidney organoid produced by the method of the present invention is an option for treating nephron loss through transplantation into humans, and is expected to be utilized as a kidney on a chip, which is an in vitro kidney model.

公开(公告)号：US20210268150A1

公开(公告)日：2021-09-02

申请号：US17021130

申请日：2020-09-15

Applicant: POSTECH Research and Business Development Foundation

Inventor： Dong-Woo CHO ,  Jae Yun KIM ,  Jae Yeon LEE

IPC: A61L27/36 ,  A61L27/38 ,  A61L27/54 ,  A61L27/52

Abstract: The method for decellularization of kidney tissue according to the present invention, the decellularized material produced through the method, and a bioink comprising the decellularized material have the effect of maximizing the effect of kidney treatment by maximizing the content of components specialized for kidney treatment such as the collecting duct and renal tubule of the kidney.