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公开(公告)号：US20250108555A1
公开(公告)日：2025-04-03
申请号：US18834811
申请日：2023-01-04
Applicant: POSTECH Research and Business Development Foundation , PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
Inventor： Dong-Woo CHO , Byoung Soo KIM , Won-Woo CHO , Min Jun AHN
IPC: B29C64/106 , B29C64/209 , B29C64/264 , B29L31/00 , B33Y10/00 , B33Y70/00 , B33Y80/00
Abstract: The present invention relates to a method for producing an artificial scalp model using a 3D printing-based multi-point multi-nozzles, and an artificial scalp model manufactured by using same, in which a dermal mimetic body can be created by using a plurality of nozzle arrays, a pore mimic structure can be generated, and hair follicle spheroids can then be created by 3D printing. In the method for producing an artificial scalp model using a 3D printing-based multi-point multi-nozzles and the artificial scalp model manufactured by using same, according to the present invention, by mimicking the hair of a healthy scalp, a plurality of arrayed hair follicle cells can be generated by 3D printing, and by using this, the effect of maximizing the treatment effect of scarring alopecia is obtained.
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公开(公告)号：US20240382654A1
公开(公告)日：2024-11-21
申请号：US18663594
申请日：2024-05-14
Applicant: POSTECH Research and Business Development Foundation , INDUSTRY-ACADEMIC COORPERATION FOUNDATION DAEGU HAANY UNIVERSITY
Inventor： Jae Yun KIM , Tugce SEN , Jae Yeon LEE , Dong-Woo CHO
Abstract: The present invention relates to a chemical cross-linking based porous material for tissue regeneration and hemostasis, including an extracellular matrix of decellularized kidney tissue, and a method for production thereof. The porous material including an extracellular matrix of decellularized kidney tissues according to the present invention forms a chemical cross-linking bond, while the final product does not contain any existing cross-linking agent component, whereby the porous material can be utilized in biocompatible substances. Further, the porous material of the present invention does not only have rapid hemostasis but also delays degradation in a long term to thus exhibit tissue regeneration effects, so that the porous material is expected to be usefully applicable for treatment of different diseases due to tissue damage in a variety of tissues, or for hemostasis and tissue regeneration at removal of tissues or incision operation.
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Patent Agency Ranking
公开(公告)号：US20210268150A1
公开(公告)日：2021-09-02
申请号：US17021130
申请日：2020-09-15
Inventor： Dong-Woo CHO , Jae Yun KIM , Jae Yeon LEE
Abstract: The method for decellularization of kidney tissue according to the present invention, the decellularized material produced through the method, and a bioink comprising the decellularized material have the effect of maximizing the effect of kidney treatment by maximizing the content of components specialized for kidney treatment such as the collecting duct and renal tubule of the kidney.
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公开(公告)号：US20220072203A1
公开(公告)日：2022-03-10
申请号：US17126449
申请日：2020-12-18
Applicant: POSTECH Research and Business Development Foundation , THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION
Inventor： Dong-Woo CHO , Wonil Han , Narendra K. Singh , Yong Kyun Kim , Sun Ah Nam
Abstract: The present disclosure is related to a perfusable-type bio-dual proximal tubule cell construct and a producing method thereof capable of applying an in vitro artificial organ model configured to include a first bioink comprising a decellularized substance derived from a mammalian kidney tissue and human umbilical vascular endothelial cells (HUVECs) and a second bioink comprising the decellularized substance and renal proximal tubular epithelial cells (RPTECs), wherein the first bioink and the second bioink are coaxial and printed in tubular constructs having different inner diameters.
According to the present disclosure, it is possible to use the renal proximal tubule-on-a-chip as a bioreactor capable of observing a biological drug reaction similar to a real drug by perfusing various drugs to the renal proximal tubule-on-a-chip.-
5.发明申请公开(公告)号：US20200163747A1
公开(公告)日：2020-05-28
申请号：US16616593
申请日：2017-06-02
Inventor： Jeong Hun PARK , Dong-Woo CHO , Jung-Seob LEE , Ju Young PARK , Min Jun AHN , Inn Chul NAM , Sung Won KIM , Jae Yeon Lee , Jin Woo LEE , Sun Hwa PARK , Byeong Gon YUN
Abstract: The present invention relates to a bellows framework having a concave-convex structure on at least one of outer and inner sides using three-dimensional printing technology and a method of producing thereof, and an artificial tracheal replacement comprising an epithelium part formed on the inner side of the bellows framework and an annular cartilage part formed along the circumference of concave-convex grooves on the outer side and a method of producing thereof.
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6.发明申请公开(公告)号：US20250109383A1
公开(公告)日：2025-04-03
申请号：US18834936
申请日：2023-01-04
Applicant: POSTECH Research and Business Development Foundation , PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
Inventor： Dong-Woo CHO , Byoung Soo KIM , Won-Woo CHO , Min Jun AHN
Abstract: The present invention relates to a method for producing an adipose model through environmental control and an adipose model created using same, the method comprising the steps of: providing a first bioink, which is cell-unfriendly; creating a bath suspension with a predetermined volume by using the first bioink; providing a second bioink comprising preadipocytes; 3Dprinting the second bioink in the bath suspension so as to produce an adipose model; and culturing the bath suspension in which the adipose model is disposed. The method for producing an adipose model through environmental control and the adipose model created using same, according to the present disclosure, form environments for a 3D-printed adipose model, and limit the proliferation area of adipose cells and induce the differentiation thereof, and thus can maximize similarity with actual adipose tissues.
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公开(公告)号：US20230174950A1
公开(公告)日：2023-06-08
申请号：US17995114
申请日：2020-11-24
Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION , POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION
Inventor： Yong Kyun KIM , Dong-Woo CHO , Sun Ah NAM , Jin Won KIM , Jae Yeon LEE , Jae Yun KIM
CPC classification number: C12N5/0697 , A61K35/22 , C12N5/0686 , C12N2506/45 , C12N2513/00 , C12N2533/54 , C12N2533/90
Abstract: The present invention relates to a kidney organoid having a nephron-like structure and a production method therefor. A kidney organoid culture system using kidney dECM hydrogels according to the present invention induced the vascularization of the kidney organoid and the expression of podocytes, tubular transporters, and cilium genes, and has an effect of forming a more mature nephron-like structure. Therefore, the kidney organoid produced by the method of the present invention is an option for treating nephron loss through transplantation into humans, and is expected to be utilized as a kidney on a chip, which is an in vitro kidney model.
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