公开(公告)号：US11919971B2

公开(公告)日：2024-03-05

申请号：US16302023

申请日：2017-05-16

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Daniel Christopher Leslie ,  Thomas Doyle ,  Anna Waterhouse ,  Melissa Rodas ,  Alexander L. Watters ,  Michael Super ,  Donald E. Ingber

IPC: C07K17/08 ,  C08L25/06 ,  C08L83/04 ,  G01N33/543 ,  G01N33/545 ,  C08K5/05

CPC classification number: C07K17/08 ,  C08L25/06 ,  C08L83/04 ,  G01N33/54393 ,  G01N33/545 ,  C08K5/05 ,  C08L2203/02

Abstract: This disclosure provides, e.g., methods for coupling Formation of Surface Carboxylates on PES an entity to a solid substrate. The method can comprise treating the with Exposure Time substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.