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公开(公告)号：US20240209073A1
公开(公告)日：2024-06-27
申请号：US18422712
申请日：2024-01-25
发明人： Tarlochan S. Nijjar , Robin Barbour , Philip James Dolan, III , Yue Liu , Svetlana Alexander , Mark E. Renz
CPC分类号： C07K16/18 , C12N15/63 , A61K9/0019 , A61K45/06 , C07K2317/565
摘要： The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.
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公开(公告)号：US11267877B2
公开(公告)日：2022-03-08
申请号：US16753307
申请日：2018-10-05
发明人： Joshua Reginald Salmans , Svetlana Alexander , Robin Barbour , Jeffrey N. Higaki , Tarlochan S. Nijjar
IPC分类号： C07K16/18 , A61K31/713 , A61K45/06 , A61K39/00
摘要： The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, and for monitoring the efficacy of TTR therapies, among other applications.
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公开(公告)号：US20210261652A1
公开(公告)日：2021-08-26
申请号：US17181997
申请日：2021-02-22
发明人： Tarlochan S. Nijjar , Robin BARBOUR , Philip James DOLAN, III , Yue LIU , Svetlana ALEXANDER , Mark E. RENZ
摘要： The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.
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公开(公告)号：US10597441B2
公开(公告)日：2020-03-24
申请号：US16144923
申请日：2018-09-27
发明人： Jose Saldanha , Tarlochan S. Nijjar
摘要： The present application discloses humanized 1H7 antibodies. The antibodies bind to human alpha synuclein and can be used for treatment and diagnosis of Lewy body disease.
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公开(公告)号：US10464999B2
公开(公告)日：2019-11-05
申请号：US15201423
申请日：2016-07-02
摘要： The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.
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公开(公告)号：US10442855B2
公开(公告)日：2019-10-15
申请号：US15199236
申请日：2016-06-30
摘要： The invention provides antibodies that specifically bind to medin. The antibodies have the capacity to bind to monomeric, misfolded, aggregated, fibril or deposited forms of medin. The antibodies can be used for treating or effecting prophylaxis of diseases associated with medin, medin accumulation or accumulation of medin deposits (e.g., medin amyloidosis). The antibodies can also be used for diagnosing medin amyloidosis and inhibiting or reducing aggregation of medin, among other applications.
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公开(公告)号：US20190153080A1
公开(公告)日：2019-05-23
申请号：US16144923
申请日：2018-09-27
发明人： Jose Saldanha , Tarlochan S. Nijjar
摘要： The present application discloses humanized 1H7 antibodies. The antibodies bind to human alpha synuclein and can be used for treatment and diagnosis of Lewy body disease.
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公开(公告)号：US10118960B2
公开(公告)日：2018-11-06
申请号：US15587255
申请日：2017-05-04
发明人： Jose Saldanha , Tarlochan S. Nijjar
摘要： The present application discloses humanized 1H7 antibodies. The antibodies bind to human alpha synuclein and can be used for treatment and diagnosis of Lewy body disease.
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公开(公告)号：US09951131B2
公开(公告)日：2018-04-24
申请号：US14329475
申请日：2014-07-11
发明人： Robin Barbour , Tarlochan S. Nijjar
IPC分类号： C07K16/26 , A61K39/395 , G01N33/66 , A61K39/00
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/92 , G01N33/66 , Y10T436/144444
摘要： The invention provides monoclonal antibody 3H6 and related antibodies. The 3H6 antibody binds to an epitope within residues 28-36 of IAPP. The antibodies of the invention are useful, for example, for treating disorders associated with IAPP accumulation, particularly accumulation of IAPP deposits. Such disorders include type 2 diabetes, metabolic syndrome, impaired insulin tolerance, impaired glucose tolerance, insulinomas, and related conditions.
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公开(公告)号：US20160251418A1
公开(公告)日：2016-09-01
申请号：US15009662
申请日：2016-01-28
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.
摘要翻译： 本发明提供了特异性结合转甲状腺素蛋白（TTR）的抗体。 抗体可用于治疗或预防与TTR积累或TTR沉积物积聚（例如，TTR淀粉样变性）相关的疾病或病症。 抗体也可用于诊断TTR淀粉样变性和抑制或减少TTR的聚集，以及其他应用。
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