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公开(公告)号：US10059761B2
公开(公告)日：2018-08-28
申请号：US14656619
申请日：2015-03-12
发明人： Stephen Jed Tam , Yue Liu , Robin Barbour , Theodore Yednock , Kenneth Flanagan
IPC分类号： C07K16/18 , G01N33/574 , A61K47/48 , A61K39/00
CPC分类号： C07K16/18 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/57488 , G01N2333/78
摘要： The invention provides antibodies that specifically bind to the LG4-5 modules of the G domain of laminin α4. The antibodies can preferentially stain cancer or tumor cells or tissue. The antibodies can be used for detecting cancer, evaluating the efficacy of a cancer therapy, treating cancer, and treating obesity or obesity-related diseases, among other applications.
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公开(公告)号：US20180208646A1
公开(公告)日：2018-07-26
申请号：US15918937
申请日：2018-03-12
发明人： Stephen Jed Tam , Yue Liu , Robin Barbour , Theodore Yednock , Kenneth Flanagan
IPC分类号： C07K16/18 , G01N33/574 , A61K47/68 , A61K39/00
CPC分类号： C07K16/18 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/57488 , G01N2333/78
摘要： The invention provides antibodies that specifically bind to the LG4-5 modules of the G domain of laminin α4. The antibodies can preferentially stain cancer or tumor cells or tissue. The antibodies can be used for detecting cancer, evaluating the efficacy of a cancer therapy, treating cancer, and treating obesity or obesity-related diseases, among other applications.
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公开(公告)号：US10889636B2
公开(公告)日：2021-01-12
申请号：US15918937
申请日：2018-03-12
发明人： Stephen Jed Tam , Yue Liu , Robin Barbour , Theodore Yednock , Kenneth Flanagan
IPC分类号： A61K47/68 , C07K16/18 , G01N33/574 , A61K39/00
摘要： The invention provides antibodies that specifically bind to the LG4-5 modules of the G domain of laminin α4. The antibodies can preferentially stain cancer or tumor cells or tissue. The antibodies can be used for detecting cancer, evaluating the efficacy of a cancer therapy, treating cancer, and treating obesity or obesity-related diseases, among other applications.
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公开(公告)号：US20170158755A1
公开(公告)日：2017-06-08
申请号：US15125569
申请日：2015-03-12
发明人： Kenneth Flanagan , Stephen Jed Tam , Yue Liu , Theodore Yednock , Robin Barbour
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： The invention provides antibodies that specifically bind to the LG1-3 modules of the G domain of laminin α4. The antibodies have the capacity to inhibit binding of laminin α4 to MCAM. The antibodies can be used for inhibiting undesired immune responses, treatment of cancer, or treatment of obesity or obesity-related diseases, among other applications.
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公开(公告)号：US20170002077A1
公开(公告)日：2017-01-05
申请号：US15125568
申请日：2015-03-12
发明人： Stephen Jed Tam , Theodore Yednock , Yue Liu , Nicholas Schwab , Heinz Wiendl , Tilman Schneider-Hohendorf
CPC分类号： C07K16/2839 , A61K2039/507 , A61K2039/54 , A61K2039/545 , C07K16/3092 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The present application provides evidence that a combined blockade against alpha-4 integrin and MCAM is more effective than against either molecule alone. In consequence, the invention provides methods of combination treatment in which both an antagonist of alpha-4 integrin and an MCAM antagonist are administered to a subject having or at risk of multiple sclerosis or other autoimmune disease.
摘要翻译： 本申请提供证据表明，针对α-4整联蛋白和MCAM的联合阻断比单独的任一分子更有效。 因此，本发明提供了组合治疗方法，其中将α-4整联蛋白和MCAM拮抗剂的拮抗剂二者施用于具有多发性硬化或其它自身免疫疾病风险的受试者。
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公开(公告)号：US20150259408A1
公开(公告)日：2015-09-17
申请号：US14656619
申请日：2015-03-12
发明人： Stephen Jed Tam , Yue Liu , Robin Barbour , Theodore Yednock
IPC分类号： C07K16/18 , A61K47/48 , G01N33/574
CPC分类号： C07K16/18 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/57488 , G01N2333/78
摘要： The invention provides antibodies that specifically bind to the LG4-5 modules of the G domain of laminin α4. The antibodies can preferentially stain cancer or tumor cells or tissue. The antibodies can be used for detecting cancer, evaluating the efficacy of a cancer therapy, treating cancer, and treating obesity or obesity-related diseases, among other applications.
摘要翻译： 本发明提供了特异性结合层粘连蛋白α4的G结构域的LG4-5模块的抗体。 抗体可以优先染色癌症或肿瘤细胞或组织。 抗体可以用于检测癌症，评估癌症治疗的疗效，治疗癌症以及治疗肥胖或肥胖相关疾病以及其它应用。
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公开(公告)号：US20200165336A1
公开(公告)日：2020-05-28
申请号：US16691525
申请日：2019-11-21
摘要： Described herein are MCAM antagonists, including MCAM antagonist antibodies capable of inhibiting the interaction between MCAM and it ligand, a laminin a4 chain, e.g., an ct4 chain of laminin 41 1. These MCAM antagonists, e.g., anti-MCAM antibodies, may be useful to treat neuroinflammatory conditions, for example, multiple sclerosis and Parkinson's disease, by inhibiting the infiltration of MCAM-expressing cells into the central nervous system (CNS), e.g., extravasation of TH 17 cells into the CNS.
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公开(公告)号：US10654920B2
公开(公告)日：2020-05-19
申请号：US15991998
申请日：2018-05-29
发明人： Stephen Jed Tam , Yue Liu , Robin Barbour , Theodore Yednock , Kenneth Flanagan
IPC分类号： G01N33/574 , C07K16/18 , A61K47/68 , A61K39/00
摘要： The invention provides antibodies that specifically bind to the LG4-5 modules of the G domain of laminin α4. The antibodies can preferentially stain cancer or tumor cells or tissue. The antibodies can be used for detecting cancer, evaluating the efficacy of a cancer therapy, treating cancer, and treating obesity or obesity-related diseases, among other applications.
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公开(公告)号：US20180371067A1
公开(公告)日：2018-12-27
申请号：US15991998
申请日：2018-05-29
发明人： Stephen Jed Tam , Yue Liu , Robin Barbour , Theodore Yednock , Kenneth Flanagan
IPC分类号： C07K16/18
摘要： The invention provides antibodies that specifically bind to the LG4-5 modules of the G domain of laminin α4. The antibodies can preferentially stain cancer or tumor cells or tissue. The antibodies can be used for detecting cancer, evaluating the efficacy of a cancer therapy, treating cancer, and treating obesity or obesity-related diseases, among other applications.
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