公开(公告)号：US20240189475A1

公开(公告)日：2024-06-13

申请号：US18316623

申请日：2023-05-12

Applicant: PUKYONG NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

Inventor： Won-Kyo Jung ,  Milan Pathum Chandika ,  Tae-Hee Kim ,  Se-Chang Kim

IPC: A61L15/26 ,  A61L15/40 ,  A61L15/42 ,  A61L27/18 ,  A61L27/36 ,  A61L27/50

CPC classification number: A61L15/26 ,  A61L15/40 ,  A61L15/42 ,  A61L27/18 ,  A61L27/3633 ,  A61L27/50 ,  B82Y5/00

Abstract: An example embodiment of the present disclosure relates to a nanofiber scaffold including polycaprolactone (poly(ε-caprolactone; PCL), decellularized extracellular matrix (dECM) and usnic acid (UA), and a preparation method thereof. The nanofiber scaffold of an example embodiment of the present disclosure has a uniform nanofiber structure, good fluid absorption and retention, moderate release rate, high mechanical stability, thermal stability, and semi-crystalline structure, and exhibits excellent antibacterial efficacy against fungi/bacteria such as Candida albicans, and good compatibility with human-derived fibroblasts.