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1.发明授权公开(公告)号：US09139654B2
公开(公告)日：2015-09-22
申请号：US12977843
申请日：2010-12-23
申请人： Pablo Umaña , Joël Jean-Mairet , James E. Bailey , M. Sean Bailey
发明人： Pablo Umaña , Joël Jean-Mairet , James E. Bailey
CPC分类号： C07K16/2887 , C07K16/00 , C07K16/2896 , C07K16/3053 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2319/30 , C12P21/005 , Y10S977/802
摘要： The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins with improved therapeutic properties, e.g., antibodies, antibody fragments, or a fusion protein that includes a region equivalent to the Fc region of an immunoglobulin, with enhanced Fc-mediated cellular cytotoxicity.
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2.发明授权Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity 有权抗体糖基化变体具有增加的抗体依赖性细胞毒性公开(公告)号：US08021856B2
公开(公告)日：2011-09-20
申请号：US11199232
申请日：2005-08-09
发明人： Pablo Umaña , Joël Jean-Mairet , James E. Bailey
IPC分类号： C12P21/08 , A61K39/395
CPC分类号： C07K16/2887 , A61K2039/505 , C07K16/00 , C07K16/2896 , C07K16/30 , C07K16/3038 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C12N9/1051 , C12P21/005 , Y02P20/52
摘要： The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to glycosylation engineering to generate proteins with improved therapeutic properties, including antibodies with increased antibody-dependent cellular cytotoxicity.
摘要翻译： 本发明涉及蛋白质的糖基化工程领域。 更具体地，本发明涉及产生具有改善的治疗性质的蛋白质的糖基化工程，包括具有增加的抗体依赖性细胞毒性的抗体。
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3.发明授权公开(公告)号：US06602684B1
公开(公告)日：2003-08-05
申请号：US09294584
申请日：1999-04-20
申请人： Pablo Umaña , Joël Jean-Mairet , James E. Bailey
发明人： Pablo Umaña , Joël Jean-Mairet , James E. Bailey
IPC分类号： C12P2100
CPC分类号： C07K16/2887 , C07K16/00 , C07K16/2896 , C07K16/3053 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2319/30 , C12P21/005 , Y10S977/802
摘要： The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins with improved therapeutic properties, e.g., antibodies, antibody fragments, or a fusion protein that includes a region equivalent to the Fc region of an immunoglobulin, with enhanced Fc-mediated cellular cytotoxicity.
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4.发明授权Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity 有权用于改善抗体依赖性细胞毒性的抗体的糖基化工程公开(公告)号：US08623644B2
公开(公告)日：2014-01-07
申请号：US12790715
申请日：2010-05-28
申请人： Pablo Umaña , Joël Jean-Mairet , M. Sean Bailey
发明人： Pablo Umaña , Joël Jean-Mairet , James E. Bailey
IPC分类号： C12N5/10
CPC分类号： C07K16/2887 , C07K16/00 , C07K16/2896 , C07K16/3053 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2319/30 , C12P21/005 , Y10S977/802
摘要： The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins with improved therapeutic properties, e.g., antibodies, antibody fragments, or a fusion protein that includes a region equivalent to the Fc region of an immunoglobulin, with enhanced Fc-mediated cellular cytotoxicity.
摘要翻译： 本发明涉及蛋白质的场糖基化工程。 更具体地，本发明涉及蛋白质的糖基化工程，以提供具有改善的治疗性质的蛋白质，例如抗体，抗体片段或融合蛋白，其包含与免疫球蛋白的Fc区相当的区域，具有增强的Fc- 介导的细胞毒性。
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5.发明申请Glycosylation Engineering of Antibodies for Improving Antibody-Dependent Cellular Cytotoxicity 有权用于改善抗体依赖性细胞毒性的抗体的糖基化工程公开(公告)号：US20120122206A1
公开(公告)日：2012-05-17
申请号：US12790715
申请日：2010-05-28
申请人： Pablo Umaña , Joël Jean-Mairet
发明人： Pablo Umaña , Joël Jean-Mairet
CPC分类号： C07K16/2887 , C07K16/00 , C07K16/2896 , C07K16/3053 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2319/30 , C12P21/005 , Y10S977/802
摘要： The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins with improved therapeutic properties, e.g., antibodies, antibody fragments, or a fusion protein that includes a region equivalent to the Fc region of an immunoglobulin, with enhanced Fc-mediated cellular cytotoxicity.
摘要翻译： 本发明涉及蛋白质的场糖基化工程。 更具体地，本发明涉及蛋白质的糖基化工程，以提供具有改善的治疗性质的蛋白质，例如抗体，抗体片段或融合蛋白，其包含与免疫球蛋白的Fc区相当的区域，具有增强的Fc- 介导的细胞毒性。
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6.发明授权公开(公告)号：US09068005B2
公开(公告)日：2015-06-30
申请号：US12409349
申请日：2009-03-23
申请人： Pablo Umaña , Joël Jean-Mairet , M. Sean Bailey
发明人： Pablo Umaña , Joël Jean-Mairet , James E. Bailey
CPC分类号： C07K16/2887 , C07K16/00 , C07K16/2896 , C07K16/3053 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2319/30 , C12P21/005 , Y10S977/802
摘要： The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins with improved therapeutic properties, e.g., antibodies, antibody fragments, or a fusion protein that includes a region equivalent to the Fc region of an immunoglobulin, with enhanced Fc-mediated cellular cytotoxicity.
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7.发明授权公开(公告)号：US08999324B2
公开(公告)日：2015-04-07
申请号：US13196724
申请日：2011-08-02
申请人： Pablo Umaña , Joël Jean-Mairet
发明人： Pablo Umaña , Joël Jean-Mairet , James E. Bailey
IPC分类号： A61K39/395 , C12P21/08 , C12N9/10 , C07K16/00 , C07K16/28 , C07K16/30 , C12P21/00 , A61K39/00
CPC分类号： C07K16/2887 , A61K2039/505 , C07K16/00 , C07K16/2896 , C07K16/30 , C07K16/3038 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C12N9/1051 , C12P21/005 , Y02P20/52
摘要： The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to glycosylation engineering to generate proteins with improved therapeutic properties, including antibodies with increased antibody-dependent cellular cytotoxicity.
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8.发明授权公开(公告)号：US08629248B2
公开(公告)日：2014-01-14
申请号：US12790716
申请日：2010-05-28
申请人： Pablo Umaña , Joël Jean-Mairet , M. Sean Bailey
发明人： Pablo Umaña , Joël Jean-Mairet , James E. Bailey
IPC分类号： C07K16/00
CPC分类号： C07K16/2887 , C07K16/00 , C07K16/2896 , C07K16/3053 , C07K2317/14 , C07K2317/24 , C07K2317/41 , C07K2317/732 , C07K2319/30 , C12P21/005 , Y10S977/802
摘要： The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins with improved therapeutic properties, e.g., antibodies, antibody fragments, or a fusion protein that includes a region equivalent to the Fc region of an immunoglobulin, with enhanced Fc-mediated cellular cytotoxicity.
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