公开(公告)号：US09861303B2

公开(公告)日：2018-01-09

申请号：US14631095

申请日：2015-02-25

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： Tatsurou Kawamura ,  Yasuaki Okumura ,  Masaru Minamiguchi ,  Masahiko Shioi

IPC: A61B5/1455 ,  A61B5/145 ,  G01N21/64 ,  G01N21/65

CPC classification number: A61B5/14532 ,  A61B5/1451 ,  A61B5/1455 ,  G01N21/64 ,  G01N21/658

Abstract: An exemplary apparatus for measuring the concentration of a test substance in an organism disclosed herein includes: a measurement system which measures first and second concentrations that are concentrations of the test substance at positions A and B, respectively, where the positions A and B are located inside of the organism but outside of the blood vessel of the organism, and the position B is located more distant from the blood vessel than the position A is; and a decision circuit which determines, based on the first and second concentrations, whether or not an equilibrium has been established yet between a concentration of the test substance inside of the blood vessel and a concentration of the test substance measured at a position inside of the organism but outside of the blood vessel of the organism.

公开(公告)号：US11435286B2

公开(公告)日：2022-09-06

申请号：US16908788

申请日：2020-06-23

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： Yoshiki Sasaki ,  Tatsurou Kawamura ,  Hiroto Yanagawa

IPC: G01N21/64 ,  G01N33/569 ,  G01N33/58

Abstract: A pathogen detection apparatus includes a collector that collects a pathogen in air; a reactor that causes the pathogen collected by the collector to react with a labeled substance; a time measurer that measures time from start of reaction in the reactor; a detector that detects a quantity of labeled substance that has reacted with the pathogen; and a controller. The controller calculates a gradient value on the basis of a predetermined time period from the start of reaction measured by the time measurer and the quantity of labeled substance detected by the detector, and determines, on the basis of the gradient value, a time interval to next collection that is to be performed by the collector.

公开(公告)号：US10194939B2

公开(公告)日：2019-02-05

申请号：US14941007

申请日：2015-11-13

Applicant: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.

Inventor： Masaru Minamiguchi ,  Yasuaki Okumura ,  Tatsurou Kawamura ,  Takahiro Aoki ,  Masahiko Shioi

IPC: A61B5/00 ,  A61B17/34 ,  A61B5/1459 ,  G01N21/65 ,  G01N21/64 ,  A61B5/1455 ,  A61B5/145

Abstract: A sensor embedding device according to the present disclosure is a sensor embedding device which embeds a sensor in a subject, the sensor having a sensing region in which to detect a state of the subject, including: a needle to be inserted in the subject, the needle having a hole; a sensor retainer to retain the sensor so that the sensor is ready to be embedded inside the subject in such a manner that the sensing region is oriented in a predetermined direction; and a movable section to move the sensor into the subject with a slide of the sensor retainer inside the hole.

公开(公告)号：US11604188B2

公开(公告)日：2023-03-14

申请号：US16905915

申请日：2020-06-19

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： Tatsurou Kawamura

IPC: G01N33/543 ,  G01N21/64 ,  G01N33/553 ,  G01N33/58 ,  G02B5/00

Abstract: A detection apparatus includes: a substrate; a metal nanostructure on a surface of the substrate and on which immobilized antibodies having a property of binding with a detection object substance are immobilized, the metal microstructure generating a surface plasmon by being irradiated with excitation light; an introducer that introduces labeled antibodies having a property of binding with the detection object substance and labeled with a fluorescent material, and a test solution containing the detection object substance into the metal nanostructure; a light source that irradiates the metal nanostructure with the excitation light from the back surface side of the substrate; and a photodetector that detects the detection object substance based on fluorescence generated from the fluorescent material in response to irradiation of the excitation light. The metal nanostructure includes a light transmissive portion that transmits, to the surface side of the substrate, the excitation light emitted from the back surface side thereof.

公开(公告)号：US10684254B2

公开(公告)日：2020-06-16

申请号：US15366143

申请日：2016-12-01

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： Yasuaki Okumura ,  Tatsurou Kawamura ,  Noriko Shimba

IPC: G01N27/447 ,  B03C5/00 ,  G01N33/543

Abstract: The present invention provides a method for detecting an analyte with high sensitivity. In the present method, a solution is supplied onto a substrate comprising a first electrode and a second electrode. Then, an alternating voltage is applied between the first electrode and the second electrode to aggregate, onto the surface between the first electrode and the second electrode by dielectrophoresis, bioparticles and dielectric particles contained in the solution. The aggregated bioparticles are broken to release the analyte contained in the bioparticles. The released analyte is bound to a first antibody and a second antibody to cause the dielectric particles to be immobilized onto the substrate through formation of a sandwich structure composed of the first antibody, the analyte, and the second antibody. Finally, the analyte is detected through the fluorescent substance contained in the immobilized dielectric particles.