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28 条记录 (耗时 0.019 秒)

    7-(substituted)cycloalkylamino-1 -(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
    1.
    发明授权
    7-(substituted)cycloalkylamino-1 -(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids 失效
    7-（取代的）环烷基氨基-1-（取代的）-6-氟-1,4-二氢-4-氧代-3-喹啉羧酸

    公开(公告)号：US4992449A

    公开(公告)日：1991-02-12

    申请号：US473498

    申请日：1990-02-01

    申请人： Panayota Bitha ,  Yang-I Lin

    发明人： Panayota Bitha ,  Yang-I Lin

    IPC分类号： A61K31/47 ,  A61P31/04 ,  C07D215/56

    CPC分类号： C07D215/56

    摘要： Novel antibacterial compounds of the formula: ##STR1## in which R.sub.1 is alkyl (C.sub.1 -C.sub.4), cycloalkyl (C.sub.3 -C.sub.6), alkoxy (C.sub.1 -C.sub.4), alkylamino (C.sub.1 -C.sub.3), vinyl, phenyl, benzyl, --CH.sub.2 CH.sub.2 F or mono or polysubstituted phenyl (wherein the substituent is halogen, CF.sub.3 or OCH.sub.2 F); n is an integer of from 1 to 4; and R.sub.2 is cis or trans hydroxy, amino, mono or disubstituted alkyl (C.sub.1 -C.sub.3) amino and the pharmacologically accepted salts thereof are described.

    (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
    4.
    发明授权
    (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes 失效
    （2,2'-双（氨基甲基）-1,3-丙二醇-N，N'）铂络合物

    公开(公告)号：US4760157A

    公开(公告)日：1988-07-26

    申请号：US825023

    申请日：1986-01-31

    申请人： Ralph G. Child ,  Panayota Bitha ,  Joseph J. Hlavka ,  Yang-I Lin

    发明人： Ralph G. Child ,  Panayota Bitha ,  Joseph J. Hlavka ,  Yang-I Lin

    IPC分类号： A61K31/66 ,  A61K31/28 ,  A61P35/00 ,  C07F15/00 ,  C07F17/02

    CPC分类号： C07F15/0093

    摘要： Novel organic-platinum compounds selected from those of the formulae: ##STR1## wherein L and L' are selected from the group consisting of halide, nitrate, sulfate and a monobasic carboxylate such as acetate or hydroxy acetate or L and L' taken together are a dibasic carboxylate selected from the group consisting of ##STR2## oxalic acid, methylmalonic acid, succinic acid and tartronic acid, or L and L' taken together are a tribasic carboxylate selected from the group consisting of ##STR3## taken together is ascorbic acid and X is selected from the group consisting of halogen and hydroxy.

    摘要翻译： 新型有机铂化合物，其选自下式：其中L和L'选自卤化物，硝酸盐，硫酸盐和一元羧酸盐如乙酸盐或羟基乙酸盐或L和 L'一起是选自草酸，甲基丙二酸，琥珀酸和丙醇二酸的二元羧酸盐，或L和L'一起是选自以下的三元羧酸盐： 组合在一起的 + TR 是抗坏血酸，X选自卤素和羟基。

    3,6-disubstituted penam sulfone derivatives
    6.
    发明授权
    3,6-disubstituted penam sulfone derivatives 失效
    3,6-二取代的penam砜衍生物

    公开(公告)号：US06395726B1

    公开(公告)日：2002-05-28

    申请号：US09489623

    申请日：2000-01-24

    申请人： Yang-I. Lin ,  Panayota Bitha ,  Zhong Li ,  Gerardo D. Francisco

    发明人： Yang-I. Lin ,  Panayota Bitha ,  Zhong Li ,  Gerardo D. Francisco

    IPC分类号： A01N4300

    CPC分类号： C07D499/00

    摘要： Compounds are provided having the following formulae I and II: wherein n is 0 or 1 and when n=1, R is a 5 or 6 membered heterocyclic ring, hydroxy, halogen, oxo, carbamoyl, alkoxy, or disubstituted amino, when n=0, R is an ester, cyano or amide group; X is CH or NH; R3 is cyano, methoxy, or acetamido; R1 is hydrogen, alkyl, a negative charge, a cation selected from the group consisting of sodium, potassium and tetraalkylammonium and acyloxyalkyl, or alkoxycarbonyloxyalkyl; and R2 is hydrogen, acyl, trisubstituted silyl carbamoyl or an amino acid residue; or pharmaceutically acceptable salts thereof.

    摘要翻译： 提供具有下列通式I和II的化合物：其中n为0或1，当n = 1时，当n = 0时，R为5或6元杂环，羟基，卤素，氧代，氨基甲酰基，烷氧基或二取代的氨基， R是酯，氰基或酰胺基; X是CH或NH; R3是氰基，甲氧基或乙酰氨基; R1是氢，烷基，负电荷，选自钠，钾和四烷基铵的阳离子和酰氧基烷基 ，或烷氧基羰氧基烷基; 和R2是氢，酰基，三取代甲硅烷基氨基甲酰基或氨基酸残基; 或其药学上可接受的盐。