Transient receptor potential vanilloid 1 and uses thereof
    1.
    发明申请
    Transient receptor potential vanilloid 1 and uses thereof 审中-公开
    瞬时受体电位香草素1及其用途

    公开(公告)号:US20090131302A1

    公开(公告)日:2009-05-21

    申请号:US12082281

    申请日:2008-04-10

    IPC分类号: A61K38/00 A61K31/165 A61P1/00

    CPC分类号: A61K31/164 A61K31/20

    摘要: The present invention describes methods of retarding the development of visceral and somatic hypersensitivities in an individual. Further, the present invention describes a potentially important role for the transient receptor potential vanilloid 1 (TRPV1) in initiation and maintenance of the chronic visceral hypersensitivity and its role in development of irritable bowel syndrome.

    摘要翻译: 本发明描述了延缓个体内脏和体细胞超敏反应发展的方法。 此外,本发明描述了瞬时受体潜在香草酸1(TRPV1)在起始和维持慢性内脏超敏反应中的潜在重要作用及其在肠易激综合征发展中的作用。

    Multipart lost foam pattern and method of making same
    2.
    发明授权
    Multipart lost foam pattern and method of making same 失效
    多部分失去泡沫的图案及其制作方法

    公开(公告)号:US4673023A

    公开(公告)日:1987-06-16

    申请号:US681960

    申请日:1984-12-14

    申请人: John H. Winston

    发明人: John H. Winston

    摘要: A lost foam pattern including a first lost foam piece having a tapered inner surface defining an indentation, and a second lost foam piece received in the indentation and having a tapered outer surface in frictional engagement with the tapered inner surface, the first lost foam piece and second lost foam piece being fixedly connected solely by virtue of the frictional engagement.

    摘要翻译: 一种消失泡沫图案,包括具有限定凹陷的锥形内表面的第一消失泡沫片和容纳在所述凹陷中的第二凹陷泡沫片,并且具有与所述锥形内表面摩擦接合的锥形外表面,所述第一消失泡沫片和 第二个消失的泡沫片由于摩擦接合而完全固定连接。

    Lost foam pattern assembly equipment
    3.
    发明授权
    Lost foam pattern assembly equipment 失效
    失去泡沫图案装配设备

    公开(公告)号:US4572762A

    公开(公告)日:1986-02-25

    申请号:US583661

    申请日:1984-02-27

    申请人: John H. Winston

    发明人: John H. Winston

    摘要: A machine for assembling lost foam pattern sections. The machine has an upper retainer for holding an upper pattern section in a generally horizontal position with the surfaces to be glued facing downwardly to be contacted by a glue plate having a raised configuration depicting the glue pattern desired on the to-be-glued surfaces of the upper section. The machine provides for application of glue to the glue plate prior to moving the glue plate into contact with the upper section to transfer glue to the upper section. A lower retainer for a lower pattern section is moved into contact with the upper section long enough for the glue to set.

    摘要翻译: 用于组装失去泡沫图案部分的机器。 机器具有上部保持器,用于将上部图案部分保持在大致水平的位置,其中待胶合的表面面向下以与具有凸起构造的胶板接触,该凸起构造描绘了待粘合表面上期望的胶合图案 上部分。 在将胶板移动到与上部接触之前,该机器将胶水施加到胶板上,以将胶转移到上部。 用于下部图案部分的下部保持器被移动以与上部部分接触足够长以使胶水固定。

    Connecting rod cap alignment fixture
    4.
    发明授权
    Connecting rod cap alignment fixture 失效
    连杆盖对齐夹具

    公开(公告)号:US4223937A

    公开(公告)日:1980-09-23

    申请号:US887479

    申请日:1978-03-17

    申请人: John H. Winston

    发明人: John H. Winston

    CPC分类号: B25B1/241 B25B1/14

    摘要: A fixture for assisting in positioning the end cap of a connecting rod relative to the remainder of the rod, which fixture comprises a frame including a gauge portion having spaced ends, a first pair of angularly related wedge surfaces at one end of the gauge portion, and a handle portion extending from the other end of the gauge portion, a subframe carried by the frame for movement toward and away from the first pair of wedge surfaces and including a second pair of angularly related wedge surfaces located in spaced facing relation to the first pair of wedge surfaces, and means on the subframe and on the frame for moving the subframe relative to the first pair of wedge surfaces.

    摘要翻译: 一种用于协助相对于所述杆的其余部分定位连杆的端盖的夹具,所述夹具包括框架,所述框架包括具有间隔开的端部的量规部分,所述量规部分的一端处的第一对角度相关的楔形表面, 以及从所述量规部分的另一端延伸的手柄部分,由所述框架承载的用于朝向和远离所述第一对楔形表面移动的子架,并且包括第二对成角度相关的楔形表面,所述楔形表面位于与所述第一对 一对楔形表面,以及在子框架和框架上的装置,用于相对于第一对楔形表面移动子框架。

    Piston and piston ring construction
    5.
    发明授权
    Piston and piston ring construction 失效
    活塞和活塞环结构

    公开(公告)号:US4883029A

    公开(公告)日:1989-11-28

    申请号:US35596

    申请日:1987-04-07

    申请人: John H. Winston

    发明人: John H. Winston

    摘要: A piston assembly comprising a piston reciprocally movable along an axis and including a generally cylindrical outer surface having therein a circumferentially extending groove partially defined by a surface having therein a recess, and a piston ring located in the groove and including a lower surface extending generally perpendicularly to the axis, a first arcuate segment having an upper surface inclined radially inwardly and downwardly and having a maximum thickness and a radially inwardly decreasing thickness, and a second arcuate segment extending into the recess and having a substantially constant thickness across the radial extent thereof, the constant thickness being substantially equal to the maximum thickness.

    摘要翻译: 一种活塞组件,包括可沿轴线往复移动的活塞并且包括大致圆柱形的外表面,其中具有部分地由其中具有凹部的表面限定的周向延伸的凹槽和位于所述凹槽中的活塞环,并且包括大致垂直延伸的下表面 具有上表面径向向内和向下倾斜并具有最大厚度和径向向内减小的厚度的第一弧形段,以及延伸到所述凹部中并且在其径向范围内具有基本上恒定的厚度的第二弧形段, 恒定厚度基本上等于最大厚度。

    Apparatus and method for uniform powder feed
    6.
    发明授权
    Apparatus and method for uniform powder feed 失效
    均匀粉末进料的装置和方法

    公开(公告)号:US4059310A

    公开(公告)日:1977-11-22

    申请号:US379361

    申请日:1973-07-16

    IPC分类号: B65G53/66

    CPC分类号: B65G53/66

    摘要: Disclosed herein is an apparatus for uniformly feeding particulate matter into a carrier gas, which apparatus includes a particulate matter inlet duct communicating with a carrier gas conduit, a device for introducing into the conduit upstream of the inlet duct, a flow of carrier gas which is maintained under constant pressure prior to introduction, a particulate matter pump communicating with the inlet duct and operable at a variable pumping rate to supply particulate matter through the inlet duct to the conduit, a device for sensing the pressure in the conduit, and a control connected to the pressure sensing means for varying the pumping rate of the pump in accordance with pressure variation in the conduit to maintain a uniform feed of particulate matter into the carrier gas flowing in the conduit.

    摘要翻译: 本文公开了一种用于将颗粒物质均匀地输送到载气中的装置,该装置包括与载气导管连通的颗粒物质入口管道,用于引入入口管道上游的导管的装置, 在引入之前保持在恒定压力下的颗粒物质泵,其与入口管道连通并且以可变的泵送速率可操作以通过入口管道向管道提供颗粒物质,用于感测管道中的压力的​​装置和连接的控制器 到压力感测装置,用于根据管道中的压力变化来改变泵的泵送速率,以保持颗粒物质均匀地进入流入管道的载气中。