公开(公告)号：US11130789B2

公开(公告)日：2021-09-28

申请号：US11658220

申请日：2005-07-22

申请人： Parry John Guilford ,  Natalie Jane Kerr ,  Robert Craig Pollock

发明人： Parry John Guilford ,  Natalie Jane Kerr ,  Robert Craig Pollock

IPC分类号： C07K14/47 ,  G01N33/574 ,  C12Q1/6886

摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including bladder tumors. Members of the BTM or UBTM family can be highly and consistently accumulated in bladder tumor tissue and other tumor tissue, and/or can be accumulated in urine of patients, and thus are markers for bladder and other types of cancer. In certain embodiments, BTMs or UBTMs can accumulate in the urine, and detection of UBTM family members can be an effective diagnostic approach. In some embodiments, quantitative PCR methods have advantages over microarray methods. In other embodiments, detection and quantification of a plurality of BTMs or UBTMs can increase the sensitivity and specificity of detection of bladder cancer, and therefore provides methods for determining the stage and type of bladder cancer. Kits provide easy, convenient ways for carrying out the methods of this invention.

公开(公告)号：US20100273148A1

公开(公告)日：2010-10-28

申请号：US11658220

申请日：2005-07-22

申请人： Parry John Guilford ,  Natalie Jane Kerr ,  Robert Craig Pollock

发明人： Parry John Guilford ,  Natalie Jane Kerr ,  Robert Craig Pollock

IPC分类号： C12Q1/68 ,  G01N33/68 ,  C12Q1/26 ,  C40B30/00 ,  G01N33/566 ,  G01N33/573 ,  C12M1/00

CPC分类号： C07K14/47 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57488 ,  G01N2800/52

摘要： Early detection of tumors is a major determinant of survival of patients suffering from tumors, including bladder tumors. Members of the BTM or UBTM family can be highly and consistently accumulated in bladder tumor tissue and other tumor tissue, and/or can be accumulated in urine of patients, and thus are markers for bladder and other types of cancer. In certain embodiments, BTMs or UBTMs can accumulate in the urine, and detection of UBTM family members can be an effective diagnostic approach. In some embodiments, quantitative PCR methods have advantages over microarray methods. In other embodiments, detection and quantification of a plurality of BTMs or UBTMs can increase the sensitivity and specificity of detection of bladder cancer, and therefore provides methods for determining the stage and type of bladder cancer. Kits provide easy, convenient ways for carrying out the methods of this invention.

摘要翻译： 肿瘤的早期检测是患有肿瘤的患者（包括膀胱肿瘤）的主要决定因素。 BTM或UBTM家族的成员可以高度一致地积聚在膀胱肿瘤组织和其他肿瘤组织中，和/或可以积聚在患者的尿液中，因此是膀胱癌和其他类型癌症的标志物。 在某些实施方案中，BTM或UBTM可以积聚在尿液中，并且UBTM家族成员的检测可以是有效的诊断方法。 在一些实施方案中，定量PCR方法优于微阵列方法。 在其他实施方案中，多个BTM或UBTM的检测和定量可以增加膀胱癌检测的灵敏度和特异性，因此提供了确定膀胱癌的阶段和类型的方法。 试剂盒提供方便实施本发明方法的方便。