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1.Methods of treating a tumor that expresses APRIL by administering BCMA 有权
标题翻译: 通过施用BCMA治疗表达APRIL的肿瘤的方法公开(公告)号:US07276241B2
公开(公告)日:2007-10-02
申请号:US10115192
申请日:2002-04-02
CPC分类号: C07K14/70575 , A61K38/00 , A61K2039/505 , C07K2319/30
摘要: A novel receptor in the TNF family is provided: APRIL-R. Chimeric molecules and antibodies to APRIL-R and methods of use thereof are also provided.
摘要翻译: 提供TNF家族中的新型受体:APRIL-R。 还提供了嵌合分子和对APRIL-R的抗体及其使用方法。
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公开(公告)号:US20050124543A1
公开(公告)日:2005-06-09
申请号:US11048669
申请日:2005-02-01
IPC分类号: C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/16 , A61P11/00 , A61P15/00 , A61P17/00 , A61P17/02 , A61P19/02 , A61P19/04 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P43/00 , C07K14/52 , C07K14/525 , C07K14/705 , C07K19/00 , C12N5/02 , C07K14/74 , C07K16/28
CPC分类号: C07K14/52 , A61K38/00 , C07K14/70575
摘要: A newly identified heteromeric ligand of the Tumor Necrosis Factor (TNF)-family, referred to hereinafter as “APBF” has been identified.
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公开(公告)号:US20120189634A1
公开(公告)日:2012-07-26
申请号:US13044317
申请日:2011-03-09
IPC分类号: A61K39/395 , A61P35/00
CPC分类号: C07K14/70578 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要: A method of treating a mammal for a condition associated with undesired cell proliferation comprising administering to said mammal an effective amount of a TACI reagent, wherein said reagent extends mean survival time of said mammal by about 10% or more as compared to the absence of administering the TACI reagent.
摘要翻译: 一种治疗哺乳动物与不期望的细胞增殖相关的病症的方法,包括向所述哺乳动物施用有效量的TACI试剂,其中所述试剂与所述哺乳动物的不存在施用相比,将所述哺乳动物的平均存活时间延长约10%或更多 TACI试剂。
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公开(公告)号:US20150139992A1
公开(公告)日:2015-05-21
申请号:US14452870
申请日:2014-08-06
申请人: Jeffrey Browning , Christine Ambrose , Fabienne MacKay , Jurg Tschopp , Pascal Schneider , Jeffrey Thompson
发明人: Jeffrey Browning , Christine Ambrose , Fabienne MacKay , Jurg Tschopp , Pascal Schneider , Jeffrey Thompson
IPC分类号: C07K14/715 , C07K16/24
CPC分类号: C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要: A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
摘要翻译: 提供TNF家族中的新型受体:BAFF-R。 还提供了嵌合分子和对BAFF-R的抗体及其使用方法。
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5.Methods of screening for a compound that inhibits the interaction between BAFF and BCMA 有权
标题翻译: 筛选抑制BAFF和BCMA之间相互作用的化合物的方法公开(公告)号:US08828669B2
公开(公告)日:2014-09-09
申请号:US13401610
申请日:2012-02-21
申请人: Jeffrey Browning , Christine Ambrose , Fabienne MacKay , Jurg Tschopp , Pascal Schneider , Jeffrey Thompson
发明人: Jeffrey Browning , Christine Ambrose , Fabienne MacKay , Jurg Tschopp , Pascal Schneider , Jeffrey Thompson
IPC分类号: G01N33/53 , A61K39/395 , A61K38/17 , C07K14/705 , A61K39/00
CPC分类号: C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要: A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
摘要翻译: 提供TNF家族中的新型受体:BAFF-R。 还提供了嵌合分子和对BAFF-R的抗体及其使用方法。
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公开(公告)号:US07083785B2
公开(公告)日:2006-08-01
申请号:US10077438
申请日:2002-02-15
申请人: Jeffrey Browning , Christine Ambrose , Fabienne MacKay , Jurg Tschopp , Pascal Schneider , Jeffrey Thompson
发明人: Jeffrey Browning , Christine Ambrose , Fabienne MacKay , Jurg Tschopp , Pascal Schneider , Jeffrey Thompson
IPC分类号: A61K39/395 , C07K16/28 , C12P21/08
CPC分类号: C07K14/7151 , A61K38/17 , A61K39/00 , A61K39/395 , A61K2039/505 , C07K14/70575 , C07K16/241 , C07K2319/00
摘要: A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.
摘要翻译: 提供TNF家族中的新型受体:BAFF-R。 还提供了嵌合分子和对BAFF-R的抗体及其使用方法。
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公开(公告)号:US06875846B2
公开(公告)日:2005-04-05
申请号:US10214065
申请日:2002-08-07
IPC分类号: C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/16 , A61P11/00 , A61P15/00 , A61P17/00 , A61P17/02 , A61P19/02 , A61P19/04 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P43/00 , C07K14/52 , C07K14/525 , C07K14/705 , C07K19/00 , C12N5/02 , C07H21/04
CPC分类号: C07K14/52 , A61K38/00 , C07K14/70575
摘要: A newly identified heteromeric ligand of the Tumor Necrosis Factor (TNF)-family, referred to hereinafter as “APBF” has been identified.
摘要翻译: 已经鉴定了新鉴定的肿瘤坏死因子(TNF)家族的异聚配体(以下称为“APBF”)。
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8.BAFF, inhibitors thereof and their use in the modulation of B-cell response 失效
标题翻译: BAFF,其抑制剂及其在B细胞应答调节中的应用公开(公告)号:US06869605B2
公开(公告)日:2005-03-22
申请号:US09911777
申请日:2001-07-24
IPC分类号: C12N15/09 , A01K67/027 , A61K31/44 , A61K38/00 , A61K38/17 , A61K38/19 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P7/00 , A61P9/00 , A61P9/12 , A61P13/12 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P43/00 , C07C233/44 , C07C271/22 , C07D213/73 , C07D401/04 , C07D405/12 , C07K14/705 , C07K16/28 , C12N15/85 , A61A39/395 , C07K16/44
CPC分类号: C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0331 , A01K2267/0368 , A01K2267/0375 , A01K2267/0381 , A61K38/00 , A61K2039/505 , C07K14/70575 , C07K16/2875 , C07K16/2878
摘要: The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists.
摘要翻译: 本发明提供了治疗或预防与包含BAFF及其片段,抗体,激动剂和拮抗剂的BAFF的表达相关的病症的方法。
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公开(公告)号:US20060079457A1
公开(公告)日:2006-04-13
申请号:US11249714
申请日:2005-10-14
IPC分类号: A61K38/16
CPC分类号: C07K16/2875
摘要: The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists.
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10.BAFF, inhibitors thereof and their use in the modulation of B-cell response 审中-公开
标题翻译: BAFF,其抑制剂及其在B细胞应答调节中的应用公开(公告)号:US20100233179A1
公开(公告)日:2010-09-16
申请号:US12570518
申请日:2009-09-30
IPC分类号: A61K39/395 , A61P13/12 , A61P9/00 , A61P9/12
CPC分类号: C07K16/2875
摘要: The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists.
摘要翻译: 本发明提供了治疗或预防与包含BAFF及其片段,抗体,激动剂和拮抗剂的BAFF的表达相关的病症的方法。
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