公开(公告)号：US06770435B1

公开(公告)日：2004-08-03

申请号：US09431384

申请日：1999-11-01

申请人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  John C. Russell ,  Christi P. Scheffel ,  Stephen D. Stroupe

发明人： Patricia A. Billing-Medel ,  Maurice Cohen ,  Tracey L. Colpitts ,  Paula N. Friedman ,  Julian Gordon ,  Edward N. Granados ,  Steven C. Hodges ,  Michael R. Klass ,  Jon D. Kratochvil ,  John C. Russell ,  Christi P. Scheffel ,  Stephen D. Stroupe

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BU101 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为BU101并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BU101编码的多肽或蛋白质的抗体，以及预防组织特异性BU101多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。