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1.发明申请公开(公告)号：US20110237450A1
公开(公告)日：2011-09-29
申请号：US13009393
申请日：2011-01-19
IPC分类号： C40B30/04 , G01N33/574 , C12Q1/68 , B82Y15/00
CPC分类号： G01N33/57484 , C12Q1/6811 , C12Q1/6886 , C12Q2600/112 , C12Q2600/16 , C12Q2600/178 , G01N33/5023 , G01N33/54326 , G01N33/574 , G01N33/57419 , G01N33/57434 , G01N33/6848 , C12Q2525/205
摘要： Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
摘要翻译： 外来体可用于检测用于诊断，治疗相关或预后方法的生物标志物，以鉴定表型，例如病症或疾病，例如疾病的阶段或进展。 原核细胞外源体可用于生理状态的分析或确定表型。 可以使用来自细胞来源特异性外来体的生物标志物或标记来确定疾病，病症，疾病阶段和病症阶段的治疗方案，并且还可以用于确定治疗功效。 来自细胞来源的特异性外来体的标记物也可用于鉴定未知来源的疾病状况。
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公开(公告)号：US07479537B2
公开(公告)日：2009-01-20
申请号：US11126456
申请日：2005-05-11
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
IPC分类号： C07K5/00
CPC分类号： G01N33/57415 , A61K38/00 , C07K14/47 , C07K16/3015 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/00
摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的RNA序列和由此编码的多肽，命名为BS106并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对乳腺疾病和状况（例如乳腺癌）的倾向。 还提供了特异性结合BS106编码的多肽或蛋白质的抗体，以及预防组织特异性BS106多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤。
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公开(公告)号：US06949357B2
公开(公告)日：2005-09-27
申请号：US09092297
申请日：1998-06-05
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe , Hong Yu
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe , Hong Yu
IPC分类号： G01N33/53 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/566 , G01N33/574 , C07H21/02 , C07H21/04 , C12N15/00 , C12N15/63
CPC分类号： C07K14/47 , C07K16/18 , C12Q1/6886 , C12Q2600/136 , G01N33/57438 , G01N33/57484
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BL172 and transcribed from urinary tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary tract cancer. Also provided are antibodies which specifically bind to BL172-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BL172 polypeptide, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为BL172并从尿道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对泌尿道疾病和病症如尿道癌的倾向。 还提供了特异性结合BL172编码的多肽或蛋白质的抗体，以及预防组织特异性BL172多肽的作用的激动剂或抑制剂，该分子可用于治疗尿路疾病，肿瘤或转移瘤。
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公开(公告)号：US06391543B2
公开(公告)日：2002-05-21
申请号：US09065383
申请日：1998-04-23
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
IPC分类号： C12Q168
CPC分类号： C07K16/3069 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS118 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS118-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS118 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为PS118并从前列腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS118编码的多肽或蛋白质的抗体，以及预防组织特异性PS118多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。
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公开(公告)号：US06252047B1
公开(公告)日：2001-06-26
申请号：US09525397
申请日：2000-03-15
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe , Hong Yu
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe , Hong Yu
IPC分类号： C07K1300
CPC分类号： C07K16/3069 , A61K38/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N2500/04
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为PS108并从前列腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS108编码的多肽或蛋白质的抗体，以及预防组织特异性PS108多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。
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公开(公告)号：US6110675A
公开(公告)日：2000-08-29
申请号：US946869
申请日：1997-10-08
申请人： Maurice Cohen , Paula N. Friedman , Julian Gordon , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe , Hong Yu
发明人： Maurice Cohen , Paula N. Friedman , Julian Gordon , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe , Hong Yu
IPC分类号： C12N15/09 , C07K14/47 , C07K14/82 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68 , G01N33/574 , C12Q1/70 , C07H21/04 , C12P19/34 , G01N33/53
CPC分类号： C07K14/82 , C07K14/47 , C12Q1/6886 , G01N33/57434 , C12Q2600/136
摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS112 and transcribed from prostate tissue is described. A fully sequenced clone representing a continuous sequence of PS112 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS112-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS112 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
摘要翻译： 描述了一组由其编码的连续和部分重叠的RNA序列和多肽，称为PS112并从前列腺组织转录。 还公开了表示PS112的连续序列的完全测序的克隆。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS112编码的多肽或蛋白质的抗体，以及预防组织特异性PS112多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。
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公开(公告)号：US5939265A
公开(公告)日：1999-08-17
申请号：US964725
申请日：1997-11-05
申请人： Maurice Cohen , Paula N. Friedman , Julian Gordon , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Steven D. Stroupe
发明人： Maurice Cohen , Paula N. Friedman , Julian Gordon , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Steven D. Stroupe
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as LU103 and transcribed from lung tissue is described. A fully sequenced clone representing the longest continuous sequence of LU103 is also disclosed. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung such as lung cancer.
摘要翻译： 描述了一组由此编码的连续和部分重叠的RNA序列和多肽，命名为LU103并从肺组织转录。 还公开了表示LU103的最长连续序列的完全测序的克隆。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗，或确定个体对肺部疾病和病症的倾向，如肺癌。
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8.发明授权公开(公告)号：US06867016B1
公开(公告)日：2005-03-15
申请号：US09052855
申请日：1998-03-31
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , John C. Russell , Stephen D. Stroupe
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/30 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04 , C12N15/00
CPC分类号： C07K16/3046 , A61K38/00 , C07K14/47 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS141 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS141-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS141 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
摘要翻译： 描述了一组连续且部分重叠的cDNA序列和由此编码的多肽，命名为CS141并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS141编码的多肽或蛋白质的抗体以及预防组织特异性CS141多肽的作用的激动剂或抑制剂，该分子可用于治疗GI道疾病，肿瘤或转移瘤的治疗。
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公开(公告)号：US07122653B2
公开(公告)日：2006-10-17
申请号：US10082659
申请日：2002-02-25
申请人： Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Edward N. Granados , Michael R. Klass , John C. Russell , Stephen D. Stroupe
发明人： Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Edward N. Granados , Michael R. Klass , John C. Russell , Stephen D. Stroupe
CPC分类号： G01N33/57434
摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS190 and transcribed from prostate tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS190-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS190 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
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公开(公告)号：US07087393B2
公开(公告)日：2006-08-08
申请号：US10646873
申请日：2003-08-22
申请人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
发明人： Patricia A. Billing-Medel , Maurice Cohen , Tracey L. Colpitts , Paula N. Friedman , Julian Gordon , Edward N. Granados , Mark A. Hayden , Steven C. Hodges , Michael R. Klass , Jon D. Kratochvil , Lisa Roberts-Rapp , John C. Russell , Stephen D. Stroupe
CPC分类号： G01N33/6893 , C07K14/47 , C07K16/3046 , C12Q1/6886 , C12Q2600/136 , G01N2800/06 , Y10S435/81 , Y10S530/828
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为CS198并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS198编码的多肽或蛋白质的抗体，以及预防组织特异性CS198多肽的作用的激动剂或抑制剂，该分子可用于胃肠道疾病，肿瘤或转移瘤的治疗性治疗。
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