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1.发明申请Reagents and methods useful for detecting diseases of the gastrointestinal tract 审中-公开用于检测胃肠道疾病的试剂和方法公开(公告)号：US20050170414A1
公开(公告)日：2005-08-04
申请号：US11055308
申请日：2005-02-10
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Mark Hayden , Michael Klass , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Mark Hayden , Michael Klass , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
CPC分类号： C07K16/3046 , C07K2317/34 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS193 and transcribed from GI tract tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS193-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS193 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为CS193并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS193编码的多肽或蛋白质的抗体，以及预防组织特异性CS193多肽作用的激动剂或抑制剂，该分子可用于胃肠道疾病，肿瘤或转移瘤的治疗性治疗。
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2.发明申请Reagents and methods useful for detecting diseases of the gastrointestinal tract 审中-公开用于检测胃肠道疾病的试剂和方法公开(公告)号：US20050014189A1
公开(公告)日：2005-01-20
申请号：US10926217
申请日：2004-08-25
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Mark Hayden , Michael Klass , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Mark Hayden , Michael Klass , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS197 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS197-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS197 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为CS197并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS197编码的多肽或蛋白质的抗体，以及预防组织特异性CS197多肽的作用的激动剂或抑制剂，该分子可用于胃肠道疾病，肿瘤或转移瘤的治疗性治疗。
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3.发明申请Reagents and methods useful for detecting diseases of the gastrointestinal tract 审中-公开用于检测胃肠道疾病的试剂和方法公开(公告)号：US20050266477A1
公开(公告)日：2005-12-01
申请号：US11148108
申请日：2005-06-08
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Michael Klass , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Michael Klass , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
IPC分类号： C07H21/04 , C07K14/47 , C07K16/00 , C07K16/22 , C07K16/32 , C12N9/24 , C12N9/64 , C12P21/06 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/47 , C07K16/005 , C07K16/22 , C07K16/32 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C12Q1/6886 , C12Q2600/136 , G01N33/57419 , G01N33/57438 , G01N33/57446
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS194 and transcribed from GI tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS194-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS194 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为CS194并从胃肠道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对胃肠道疾病和病症（例如胃肠道癌）的倾向。 还提供了特异性结合CS194编码的多肽或蛋白质的抗体，以及预防组织特异性CS194多肽的作用的激动剂或抑制剂，该分子可用于治疗GI道疾病，肿瘤或转移瘤。
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公开(公告)号：US20050191633A1
公开(公告)日：2005-09-01
申请号：US10719144
申请日：2003-11-21
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/136
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS274 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS274-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS274 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为BS274并从乳腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对乳腺疾病和病症如乳腺癌的倾向。 还提供了特异性结合BS274编码的多肽或蛋白质的抗体，以及预防组织特异性BS274多肽的作用的激动剂或抑制剂，该分子可用于治疗乳腺疾病，肿瘤或转移瘤
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公开(公告)号：US20050181401A1
公开(公告)日：2005-08-18
申请号：US11043675
申请日：2005-01-26
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS116 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS116-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS116 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
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公开(公告)号：US20050255519A1
公开(公告)日：2005-11-17
申请号：US11185111
申请日：2005-07-20
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe , Hong Yu
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe , Hong Yu
IPC分类号： A61K38/00 , C07K16/30 , C12N15/12 , C12Q1/68 , G01N33/574
CPC分类号： C07K16/3069 , A61K38/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N2500/04
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为PS108并从前列腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对前列腺疾病和病症如前列腺癌的倾向。 还提供了特异性结合PS108编码的多肽或蛋白质的抗体，以及预防组织特异性PS108多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。
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公开(公告)号：US20050208567A1
公开(公告)日：2005-09-22
申请号：US11122741
申请日：2005-05-05
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Michael Klass , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Michael Klass , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
CPC分类号： C12Q1/6886 , C12Q2600/136
摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS123, and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate such as prostate cancer. Also provided are antibodies which specifically bind to PS123-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS123 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
摘要翻译： 描述了一组由其编码的连续和部分重叠的RNA序列和多肽，命名为PS123，并从前列腺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，预防或治疗或确定个体对诸如前列腺癌的前列腺疾病和病症的倾向。 还提供了特异性结合PS123编码的多肽或蛋白质的抗体，以及预防组织特异性PS123多肽的作用的激动剂或抑制剂，该分子可用于治疗前列腺疾病，肿瘤或转移瘤。
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公开(公告)号：US20050153373A1
公开(公告)日：2005-07-14
申请号：US10991681
申请日：2004-11-18
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
IPC分类号： A61K38/00 , C07K14/47 , C07K16/30 , C12Q1/68 , G01N33/574 , C07K14/705 , C12N5/06
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4748 , C07K16/3015 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57415
摘要： A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
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9.发明申请公开(公告)号：US20050282187A1
公开(公告)日：2005-12-22
申请号：US11094071
申请日：2005-03-30
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
CPC分类号： C07K16/18 , C07K14/47 , C12Q1/6886 , C12Q2600/136 , G01N33/6893 , G01N2800/348
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as UT116 and transcribed from urinary tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary tract cancer. Also provided are antibodies which specifically bind to UT116-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific UT116 polypeptide, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，其被命名为UT116并从尿道组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对泌尿道疾病和病症如尿道癌的倾向。 还提供了特异性结合UT116编码的多肽或蛋白质的抗体，以及预防组织特异性UT116多肽的作用的激动剂或抑制剂，该分子可用于治疗尿路疾病，肿瘤或转移瘤。
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公开(公告)号：US20050170407A1
公开(公告)日：2005-08-04
申请号：US11049923
申请日：2005-02-03
申请人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
发明人： Patricia Billing-Medel , Maurice Cohen , Tracey Colpitts , Paula Friedman , Julian Gordon , Edward Granados , Steven Hodges , Michael Klass , Jon Kratochvil , Lisa Roberts-Rapp , John Russell , Stephen Stroupe
IPC分类号： G01N33/574 , A61K39/00 , C07K14/47 , C07K16/18 , C07K16/30 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12Q1/6886 , C12P19/34
CPC分类号： C07K16/3023 , C07K2317/34 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as LS170 and transcribed from lung tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung, such as lung cancer. Also provided are antibodies which specifically bind to a LS170-encoded polypeptide or protein, and agonists or inhibitors which prevent action of tissue-specific LS170 polypeptides, which molecules are useful for the therapeutic treatment of lung diseases, tumors or metastases.
摘要翻译： 描述了一组连续和部分重叠的cDNA序列和由此编码的多肽，命名为LS170并从肺组织转录。 这些序列可用于检测，诊断，分期，监测，预后，体内成像，预防或治疗或确定个体对肺的疾病和状况（例如肺癌）的倾向。 还提供了特异性结合LS170编码的多肽或蛋白质的抗体，以及预防组织特异性LS170多肽作用的激动剂或抑制剂，该分子可用于治疗肺部疾病，肿瘤或转移瘤。
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