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    Tetracyclic indole derivatives
    2.
    发明授权
    Tetracyclic indole derivatives 失效
    四环吲哚衍生物

    公开(公告)号：US4317912A

    公开(公告)日：1982-03-02

    申请号：US129333

    申请日：1980-03-11

    申请人： Aldemio Temperilli ,  Sergio Mantegani ,  Giuliana Arcari ,  Anna M. Caravaggi

    发明人： Aldemio Temperilli ,  Sergio Mantegani ,  Giuliana Arcari ,  Anna M. Caravaggi

    IPC分类号： C07D457/02 ,  A61K31/40 ,  A61K31/48 ,  A61P9/12 ,  C07D487/06 ,  A61K31/445 ,  A61K31/535 ,  C07D487/00

    CPC分类号： C07D487/06

    摘要： A compound is disclosed of the formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom, or a carboxy, alkoxycarbonyl, piperidinocarbonyl, 1-pyrrolidinylcarbonyl, morpholinocarbonyl, carbamoyl or benzylcarbamoyl group, or an alkylcarbamoyl or dialkylcarbamoyl group in which the, or each, alkyl group has from 1 to 4 carbon atoms;R.sub.2 represents a hydrogen or fluorine atom, or a cyano, acetyl or carbamoyl group; andR.sub.3 represents a hydrogen atom or a methyl group; and represents a single or a double bond, with the proviso that R.sub.1 and R.sub.2 do not simultaneously represent hydrogen atoms;or a pharmaceutically acceptable salt thereof.

    摘要翻译： 公开了式（I）的化合物：其中R 1表示氢原子，或羧基，烷氧基羰基，哌啶子基羰基，1-吡咯烷基羰基，吗啉代羰基，氨基甲酰基或苄基氨基甲酰基，或烷基氨基甲酰基或二烷基氨基甲酰基 其中或每个烷基具有1至4个碳原子; R2表示氢或氟原子，或氰基，乙酰基或氨基甲酰基; 并且R 3表示氢原子或甲基; 并且表示单键或双键，条件是R1和R2不同时表示氢原子; 或其药学上可接受的盐。

    Ergot derivatives
    3.
    发明授权
    Ergot derivatives 失效
    Ergot衍生物

    公开(公告)号：US4321381A

    公开(公告)日：1982-03-23

    申请号：US188620

    申请日：1980-09-19

    申请人： Sergio Mantegani ,  Guiliana Arcari ,  Anna M. Caravaggi ,  Germano Bosisio

    发明人： Sergio Mantegani ,  Guiliana Arcari ,  Anna M. Caravaggi ,  Germano Bosisio

    IPC分类号： C07D457/04 ,  A61K31/48 ,  A61P9/12 ,  C07D457/02 ,  A61K31/495

    CPC分类号： C07D457/02

    摘要： Compounds and process for making same are disclosed, the compounds having the formula (I): ##STR1## wherein R.sub.1 represents methyl, phenyl, piperidino, 1-pyrrolidinyl, morpholino or 4-methyl-1-piperazinyl, alkyl or alkoxy having from 1 to 4 carbon atoms, amino, substituted amino of the formula NHR' (wherein R' is alkyl having from 1 to 4 carbon atoms, cycloalkyl, a benzyl, or phenyl) or substituted amino of the formula NR" R"' (wherein R" and R"' both represent alkyl having from 1 to 4 carbon atoms);R.sub.2 represents a hydrogen atom, alkyl having from 1 to 4 carbon atoms, or phenyl;R.sub.3 represents a fluorine atom, cyano, difluoromethyl, difluorobromomethyl, trifluoromethyl, methylthio, methylsulphonyl, sulphonamido, an alkoxy having from 1 to 4 carbon atoms, an alkanoyl having from 2 to 5 carbon atoms, or benzoyl;R.sub.4 represents a hydrocarbon having from 1 to 4 carbon atoms;R.sub.5 represents a hydrogen atom or methoxy;R.sub.6 represents a hydrogen or halogen atom or methyl; andR.sub.7 represents a hydrogen atom or methyl. The 2-cyano derivatives are especially preferred.The compounds are useful as antihypertensive agents.

    Ergot derivatives
    4.
    发明授权
    Ergot derivatives 失效
    Ergot衍生物

    公开(公告)号：US4252941A

    公开(公告)日：1981-02-24

    申请号：US72289

    申请日：1979-09-04

    申请人： Sergio Mantegani ,  Giuliana Arcari ,  Anna M. Caravaggi ,  Germano Bosisio

    发明人： Sergio Mantegani ,  Giuliana Arcari ,  Anna M. Caravaggi ,  Germano Bosisio

    IPC分类号： C07D457/04 ,  A61K31/48 ,  A61P9/12 ,  C07D457/02

    CPC分类号： C07D457/02

    摘要： Compounds and process for making same are disclosed, the compounds having the formula (I): ##STR1## wherein R.sub.1 represents a methyl, phenyl, piperidino, 1-pyrrolidinyl, morpholino or 4-methyl-1-piperazinyl group, an alkyl or alkoxy group having from 1 to 4 carbon atoms, an amino group, a substituted amino group of the formula NHR' (wherein R' represents an alkyl group having from 1 to 4 carbon atoms, a cycloalkyl group, a benzyl group, or a phenyl group) or a substituted amino group of the formula NR" R"' (wherein R" and R"' both represent alkyl groups having from 1 to 4 carbon atoms);R.sub.2 represents a hydrogen atom, an alkyl group having from 1 to 4 carbon atoms, or a phenyl group;R.sub.3 represents a fluorine atom, a cyano, difluoromethyl, difluorobromomethyl, trifluoromethyl, methylthio, methylsulphonyl, or sulphonamido group, an alkoxy group having from 1 to 4 carbon atoms, an acyl group having from 2 to 4 carbon atoms, or a benzoyl group;R.sub.4 represents a hydrocarbon group having from 1 to 4 carbon atoms;R.sub.5 represents a hydrogen atom or a methoxy group;R.sub.6 represents a hydrogen or halogen atom or a methyl group; andR.sub.7 represents a hydrogen atom or a methyl group.The 2-cyano derivatives are especially preferred.

    摘要翻译： 公开了化合物及其制备方法，具有式（I）的化合物：其中R 1表示甲基，苯基，哌啶子基，1-吡咯烷基，吗啉代或4-甲基-1-哌嗪基， 具有1至4个碳原子的烷基或烷氧基，氨基，式NHR'的取代氨基（其中R'表示具有1至4个碳原子的烷基，环烷基，苄基或 苯基）或式NR“R”'的取代氨基（其中R“和R”“均表示具有1至4个碳原子的烷基）; R2表示氢原子，具有1至4个碳原子的烷基或苯基; R 3表示氟原子，氰基，二氟甲基，二氟溴甲基，三氟甲基，甲硫基，甲磺酰基或磺酰胺基，具有1至4个碳原子的烷氧基，具有2至4个碳原子的酰基或苯甲酰基; R4表示具有1至4个碳原子的烃基; R5表示氢原子或甲氧基; R6表示氢或卤素原子或甲基; 并且R 7表示氢原子或甲基。 2-氰基衍生物是特别优选的。