专利检索 ap:("Patrick Pfister" OR "Matthew E. Rogers" OR "Khalid Jerod Parris") AND inv:"Khalid Jerod Parris" 第 1 页

1.

发明授权
Methods of identifying, isolating and using odorant and aroma receptors 有权

公开(公告)号：US09914760B2

公开(公告)日：2018-03-13

申请号：US14318641

申请日：2014-06-28

申请人： Patrick Pfister , Matthew E. Rogers , Khalid Jerod Parris

发明人： Patrick Pfister , Matthew E. Rogers , Khalid Jerod Parris

IPC分类号： C12Q1/68 , C07K14/705 , G01N33/50

CPC分类号： C07K14/705 , C12Q1/6809 , C12Q2600/136 , G01N33/5058 , G01N2333/705 , G01N2500/04 , G01N2570/00

摘要： Provided here are new methods to identify specific families of mammalian odorant receptors for odorants or aroma, particularly indole and skatole malodors and their use in assays that may be used to discover compounds that modulate (blocking, enhancing, masking or mimicking compounds) their activity. Orphan mouse odorant receptors are identified from olfactory sensory neurons that respond to target compounds. The resulting receptors as well as their human counterparts can be screened in assays against test compounds to confirm their identity as odorant or aroma receptors, particularly malodor receptors and subsequently discover for example modulators that inhibit the perception of the malodor in humans.