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公开(公告)号：US4765989A
公开(公告)日：1988-08-23
申请号：US902915
申请日：1986-09-02
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains an osmotic composition comprising a beneficial drug selected from the group consisting of nifedipine, prazosin and doxazosin, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
摘要翻译： 公开了渗透系统，其包括围绕隔室的至少一部分半渗透材料的壁。 隔室含有渗透组合物，其包含选自硝苯地平，哌唑嗪和多沙唑嗪的有益药物，以及第二和不同的渗透组合物。 墙壁上的通道将第一个组合物与系统的外部连接起来。
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公开(公告)号：US5082668A
公开(公告)日：1992-01-21
申请号：US595140
申请日：1990-10-09
CPC分类号： A61K9/0004
摘要： A device is disclosed comprising a wall that surrounds a compartment. The compartment comprises a beneficial agent composition and a push composition. A passageway in the wall connects the compartment with the exterior of the device for delivering the beneficial agent at a rate governed, in combination, by the wall, the beneficial agent composition and the push composition through the passageway of the device over time.
摘要翻译： 公开了一种包括围绕隔室的壁的装置。 隔室包含有益剂组合物和推组合物。 壁中的通道将隔室与装置的外部连接，用于通过墙壁，有益剂组合物和推动组合物通过装置的通道随时间而被组合地传递有益剂。
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公开(公告)号：US4837111A
公开(公告)日：1989-06-06
申请号：US173524
申请日：1988-03-21
IPC分类号： A61K9/00 , A61K9/22 , A61K9/36 , A61K31/505 , A61P25/02
CPC分类号： A61K9/0004 , A61K31/505
摘要： An osmotic dosage system is disclosed for delivering the therapeutically beneficial drug doxazosin to an environment of use over time.
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公开(公告)号：US4783337A
公开(公告)日：1988-11-08
申请号：US912712
申请日：1986-09-29
CPC分类号： A61K9/0004 , Y10S428/913 , Y10T428/249994
摘要： An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial drug selected from the group consisting of a calcium antagonist, angiotensin enzyme inhibitor and nonsteroidal antiinflammatory drugs, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
摘要翻译： 公开了渗透系统，其包括围绕隔室的至少一部分半渗透材料的壁。 隔室包含第一渗透组合物，其包含选自钙拮抗剂，血管紧张素酶抑制剂和非甾体抗炎药物的有益药物，以及第二和不同的渗透组合物。 墙壁上的通道将第一个组合物与系统的外部连接起来。
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公开(公告)号：US5413572A
公开(公告)日：1995-05-09
申请号：US203135
申请日：1994-02-18
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K9/52 , A61K9/66
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
摘要翻译： 公开了用于将有益剂制剂递送到使用环境的渗透系统。 渗透系统包括（a）外部半透壁，（b）中间渗透活性层，（c）包含有益剂的胶囊，和（d）用于从渗透系统分配有益剂的通道。
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6.发明授权Osmotic dosage system for delivering a formulation comprising liquid carrier and drug 失效用于递送包含液体载体和药物的制剂的渗透剂量系统
公开(公告)号：US5324280A
公开(公告)日：1994-06-28
申请号：US502705
申请日：1990-04-02
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K9/52 , A61K9/66
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
摘要翻译： 公开了用于将有益剂制剂递送到使用环境的渗透系统。 渗透系统包括（a）外部半透壁，（b）中间渗透活性层，（c）包含有益剂的胶囊，和（d）用于从渗透系统分配有益剂的通道。
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公开(公告)号：US5830501A
公开(公告)日：1998-11-03
申请号：US964548
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. -L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. -L. Wong , Jerry D. Childers , Brian L. Barclay
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译： 公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。 剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。
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公开(公告)号：US5200195A
公开(公告)日：1993-04-06
申请号：US804137
申请日：1991-12-06
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译： 公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。 剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。
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公开(公告)号：US5053032A
公开(公告)日：1991-10-01
申请号：US633590
申请日：1990-12-21
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： An osmotic device for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device comprises a wall surrounding a compartment housing a layer of an agent that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer of a fluid swellable, hydrophilic polymer. A passageway in the wall connects the agent with the exterior of the device. The wall is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer. In one embodiment the beneficial agent has a different color than the hydrophilic polymer. The wall is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent remaining to be delivered. Marking lines may be provided on the wall indicating the amount of drug/agent which has been delivered and/or the amount remaining to be delivered.
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公开(公告)号：US5021053A
公开(公告)日：1991-06-04
申请号：US380229
申请日：1989-07-14
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： An osmotic device for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device comprises a wall surrounding a compartment housing a layer of an agent that is insoluble to very soluble in aqueous biological fluid, e.g., saliva, and a layer of a fluid swellable, hydrophilic polymer. A passageway in the wall connects the agent with the exterior of the device. The wall is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer. In one embodiment the beneficial agent has a different color than the hydrophilic polymer. The wall is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent remaining to be delivered. Marking lines may be provided on the wall indicating the amount of drug/agent which has been delivered and/or the amount remaining to be delivered.
摘要翻译： 公开了用于将有益药物（例如抗真菌）递送到人类患者的口腔中的渗透装置。 该装置的尺寸和形状适应于舒适地保持在口中长时间。 该装置包括一个围绕隔室的壁，该隔室容纳不溶于非常可溶于水生物流体例如唾液的一层试剂，以及一层流体可溶胀的亲水性聚合物。 墙壁上的一个通道可将药剂与装置的外部连接起来。 该壁对于水性生物流体的通道是可渗透的，但是对亲水性聚合物的通过基本上是不可渗透的。 在一个实施方案中，有益剂具有与亲水性聚合物不同的颜色。 该壁足够半透明以允许患者看到剩余的待传递的药物/有益剂的量。 可以在墙上提供标记线，指示已经递送的药物/药剂的量和/或剩余的待传送量。
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