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公开(公告)号：US4765989A
公开(公告)日：1988-08-23
申请号：US902915
申请日：1986-09-02
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains an osmotic composition comprising a beneficial drug selected from the group consisting of nifedipine, prazosin and doxazosin, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
摘要翻译： 公开了渗透系统，其包括围绕隔室的至少一部分半渗透材料的壁。 隔室含有渗透组合物，其包含选自硝苯地平，哌唑嗪和多沙唑嗪的有益药物，以及第二和不同的渗透组合物。 墙壁上的通道将第一个组合物与系统的外部连接起来。
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公开(公告)号：US5082668A
公开(公告)日：1992-01-21
申请号：US595140
申请日：1990-10-09
CPC分类号： A61K9/0004
摘要： A device is disclosed comprising a wall that surrounds a compartment. The compartment comprises a beneficial agent composition and a push composition. A passageway in the wall connects the compartment with the exterior of the device for delivering the beneficial agent at a rate governed, in combination, by the wall, the beneficial agent composition and the push composition through the passageway of the device over time.
摘要翻译： 公开了一种包括围绕隔室的壁的装置。 隔室包含有益剂组合物和推组合物。 壁中的通道将隔室与装置的外部连接，用于通过墙壁，有益剂组合物和推动组合物通过装置的通道随时间而被组合地传递有益剂。
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公开(公告)号：US4837111A
公开(公告)日：1989-06-06
申请号：US173524
申请日：1988-03-21
IPC分类号： A61K9/00 , A61K9/22 , A61K9/36 , A61K31/505 , A61P25/02
CPC分类号： A61K9/0004 , A61K31/505
摘要： An osmotic dosage system is disclosed for delivering the therapeutically beneficial drug doxazosin to an environment of use over time.
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公开(公告)号：US4612008A
公开(公告)日：1986-09-16
申请号：US685092
申请日：1984-12-21
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed comprising a wall formed in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial agent, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
摘要翻译： 公开了渗透系统，其包括形成在围绕隔间的半透性材料的至少一部分中的壁。 隔室含有包含有益剂的第一渗透组合物和第二和不同的渗透组合物。 墙壁上的通道将第一个组合物与系统的外部连接起来。
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5.发明授权Agent dispenser comprising a semipermeable wall surrounding single-piece or two-piece container 失效代理分配器包括围绕单件或两件式容器的半透壁
公开(公告)号：US4814180A
公开(公告)日：1989-03-21
申请号：US941971
申请日：1986-12-15
CPC分类号： A61K9/0004 , A61M31/002
摘要： A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
摘要翻译： 公开了一种用于将有益剂递送到使用环境的分配器。 分配器包括围绕包含热响应组合物的隔室的半透壁和可膨胀组合物。 墙壁上的通道将隔间与分配器的外部相连。
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公开(公告)号：US4663148A
公开(公告)日：1987-05-05
申请号：US829633
申请日：1986-02-14
CPC分类号： A61K9/0004 , A61M31/002
摘要： A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
摘要翻译： 公开了一种用于将有益剂递送到使用环境的分配器。 分配器包括围绕包含热响应组合物的隔室的半透壁和可膨胀组合物。 墙壁上的通道将隔间与分配器的外部相连。
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公开(公告)号：US4692326A
公开(公告)日：1987-09-08
申请号：US829353
申请日：1986-02-14
CPC分类号： A61K9/0004 , A61M31/002
摘要： A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeble wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
摘要翻译： 公开了一种用于将有益剂递送到使用环境的分配器。 分配器包括围绕包含热响应组合物的隔室的半透壁和可膨胀组合物。 墙壁上的通道将隔间与分配器的外部相连。
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公开(公告)号：US4627850A
公开(公告)日：1986-12-09
申请号：US548219
申请日：1983-11-02
IPC分类号： A01N25/10 , A01N25/34 , A61J3/07 , A61K8/00 , A61K8/11 , A61K8/18 , A61K8/73 , A61K9/00 , A61K9/52 , A61L9/04 , A61M31/00 , A61Q13/00 , A61Q19/10 , B01J4/04 , C11B9/00
CPC分类号： A61K9/0004 , Y10S526/93 , Y10T428/249958 , Y10T428/249988 , Y10T428/31772
摘要： An osmotic capsule is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic capsule comprises an outer semipermeable wall surrounding and laminating an inner capsule wall formed of a different polymeric composition than the outer wall. The walls define an interior space containing the beneficial agent formulation. A passageway through the walls connects the exterior of the osmotic capsule with the interior of the osmotic capsule.
摘要翻译： 公开了一种用于将有益剂制剂递送到使用环境的渗透性胶囊。 渗透性胶囊包括围绕并层压由与外壁不同的聚合物组合物形成的内胶囊壁的外半透壁。 墙壁限定了含有有益剂制剂的内部空间。 穿过墙壁的通道将渗透胶囊的外部与渗透胶囊的内部连接。
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公开(公告)号：US4576604A
公开(公告)日：1986-03-18
申请号：US472333
申请日：1983-03-04
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed for delivering a beneficial agent. The device comprises a wall surrounding a compartment containing an agent, a passageway in the wall connecting the exterior of the device with the compartment, and (a) an agent in the wall or (b) an agent carried on the wall in the wall. The device delivers the agent from the compartment and the wall.
摘要翻译： 公开了用于递送有益剂的渗透装置。 该装置包括围绕包含试剂的隔室的壁，连接装置外部与隔室的通道，和（a）壁中的试剂或（b）承载在墙壁上的试剂。 该设备从隔室和墙壁传送代理。
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公开(公告)号：US4800056A
公开(公告)日：1989-01-24
申请号：US829356
申请日：1986-02-14
CPC分类号： A61K9/0004 , A61M31/002
摘要： A method of forming a dispenser for delivering a beneficial agent to a biological environment. A beneficial agent and an expandable composition are placed in a capsule made of fluid dissolvable material. The capsule is closed and surrounded by a semipermeable wall which is permeable to fluid but not to the beneficial agent. Then a passageway is drilled in the capsule between the exterior and the interior which contains the beneficial agent.
摘要翻译： 一种形成用于将有益剂输送到生物环境的分配器的方法。 将有益剂和可发性组合物置于由可流体溶解的材料制成的胶囊中。 胶囊被封闭并被可渗透流体而不是有益剂的半透壁围绕。 然后在包含有益剂的外部和内部之间的胶囊中钻出通道。
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