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公开(公告)号：US4765989A
公开(公告)日：1988-08-23
申请号：US902915
申请日：1986-09-02
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains an osmotic composition comprising a beneficial drug selected from the group consisting of nifedipine, prazosin and doxazosin, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
摘要翻译： 公开了渗透系统，其包括围绕隔室的至少一部分半渗透材料的壁。 隔室含有渗透组合物，其包含选自硝苯地平，哌唑嗪和多沙唑嗪的有益药物，以及第二和不同的渗透组合物。 墙壁上的通道将第一个组合物与系统的外部连接起来。
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公开(公告)号：US5082668A
公开(公告)日：1992-01-21
申请号：US595140
申请日：1990-10-09
CPC分类号： A61K9/0004
摘要： A device is disclosed comprising a wall that surrounds a compartment. The compartment comprises a beneficial agent composition and a push composition. A passageway in the wall connects the compartment with the exterior of the device for delivering the beneficial agent at a rate governed, in combination, by the wall, the beneficial agent composition and the push composition through the passageway of the device over time.
摘要翻译： 公开了一种包括围绕隔室的壁的装置。 隔室包含有益剂组合物和推组合物。 壁中的通道将隔室与装置的外部连接，用于通过墙壁，有益剂组合物和推动组合物通过装置的通道随时间而被组合地传递有益剂。
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公开(公告)号：US4837111A
公开(公告)日：1989-06-06
申请号：US173524
申请日：1988-03-21
IPC分类号： A61K9/00 , A61K9/22 , A61K9/36 , A61K31/505 , A61P25/02
CPC分类号： A61K9/0004 , A61K31/505
摘要： An osmotic dosage system is disclosed for delivering the therapeutically beneficial drug doxazosin to an environment of use over time.
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公开(公告)号：US4612008A
公开(公告)日：1986-09-16
申请号：US685092
申请日：1984-12-21
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed comprising a wall formed in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial agent, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
摘要翻译： 公开了渗透系统，其包括形成在围绕隔间的半透性材料的至少一部分中的壁。 隔室含有包含有益剂的第一渗透组合物和第二和不同的渗透组合物。 墙壁上的通道将第一个组合物与系统的外部连接起来。
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5.发明授权Osmotic dosage system for delivering a formulation comprising liquid carrier and drug 失效用于递送包含液体载体和药物的制剂的渗透剂量系统
公开(公告)号：US5324280A
公开(公告)日：1994-06-28
申请号：US502705
申请日：1990-04-02
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K9/52 , A61K9/66
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
摘要翻译： 公开了用于将有益剂制剂递送到使用环境的渗透系统。 渗透系统包括（a）外部半透壁，（b）中间渗透活性层，（c）包含有益剂的胶囊，和（d）用于从渗透系统分配有益剂的通道。
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公开(公告)号：US5413572A
公开(公告)日：1995-05-09
申请号：US203135
申请日：1994-02-18
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K9/52 , A61K9/66
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
摘要翻译： 公开了用于将有益剂制剂递送到使用环境的渗透系统。 渗透系统包括（a）外部半透壁，（b）中间渗透活性层，（c）包含有益剂的胶囊，和（d）用于从渗透系统分配有益剂的通道。
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公开(公告)号：US5198229A
公开(公告)日：1993-03-30
申请号：US710607
申请日：1991-06-05
IPC分类号： A61K9/00
CPC分类号： A61K9/0065 , A61K9/0004
摘要： The present invention is directed to a fluid-imbibing drug delivery device having a first, low density such that it floats in the stomach contents for a predetermined prolonged period of time, during which prolonged period of time it dispenses a drug or other active agent to the stomach, and having a second, higher density such that the device exits the stomach at the end of the predetermined prolonged period of time.
摘要翻译： 本发明涉及一种流体吸收药物递送装置，其具有第一低密度，使得其在胃内容物中漂浮预定的较长时间段，在此期间，其将药物或其它活性剂分配到 胃，并且具有第二较高密度，使得装置在预定的较长时间段结束时离开胃。
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公开(公告)号：US4986987A
公开(公告)日：1991-01-22
申请号：US312845
申请日：1989-02-21
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译： 一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。
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公开(公告)号：US4957494A
公开(公告)日：1990-09-18
申请号：US283631
申请日：1988-12-13
CPC分类号： A61M31/002 , A61K9/0004
摘要： A dispenser for use in a fluid environment which is capable of delivery of plurality of discrete drug containing layers in any desired delivery pattern or profile. The dispenser comprises a rigid housing containing a plurality of drug layers which may be separated by drug-free layers. An outlet is provided at one end of the housing and a fluid actuated driving means is provided between the other end of the housing and the drug layers. The portion of the housing in proximity to the driving means has a controlled permeability to water whereby, upon immersion in a fluid environment the drug layers are driven towards the outlet. Various delivery patterns are possible by appropriate selection of the comparison and dimensions of the drug and drug-free layers.
摘要翻译： 一种在流体环境中使用的分配器，其能够以任何期望的输送模式或轮廓递送多个离散的含药层。 分配器包括容纳多个药物层的刚性壳体，其可由无药物层分离。 出口设在壳体的一端，并且流体驱动的驱动装置设置在壳体的另一端和药物层之间。 壳体靠近驱动装置的部分对水具有受控的渗透性，因此当浸入流体环境中时，药物层朝着出口被驱动。 可以通过适当选择药物和无药物层的比较和尺寸来实现各种递送模式。
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公开(公告)号：US4751071A
公开(公告)日：1988-06-14
申请号：US1135
申请日：1987-01-07
CPC分类号： A61K9/0004 , A61M31/002
摘要： An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
摘要翻译： 公开了一种渗透递送系统，用于以受控和恒定的速率递送有用的试剂，该有效试剂通过有用试剂的脉冲输送调节到使用环境。
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