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公开(公告)号：US06572582B1
公开(公告)日：2003-06-03
申请号：US09447655
申请日：1999-11-23
IPC分类号： A61M3700
CPC分类号： A61J1/2093 , A61J7/0038
摘要： The present invention is directed to a mixing system for an active agent delivery device. The device comprises an elongate tubular member having first and second ends and a mixing system. The mixing system enables the entire dose of active agent to be entrained in a liquid. In use, liquid is drawn into the first end of the device, the mixing system mixes the liquid and active agent within the device and the active agent entrained in the liquid is drawn out of the second end of the member and into the patient's mouth.
摘要翻译： 本发明涉及一种用于活性剂输送装置的混合系统。 该装置包括具有第一端和第二端的细长管状构件和混合系统。 混合系统使整个剂量的活性剂被夹带在液体中。 在使用中，液体被吸入装置的第一端，混合系统将液体和活性剂混合在装置内，并且夹带在液体中的活性剂从该构件的第二端引出并进入患者的口中。
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公开(公告)号：US6024721A
公开(公告)日：2000-02-15
申请号：US950424
申请日：1997-10-15
CPC分类号： A61J1/2093 , A61J7/0038
摘要： The present invention is directed to a mixing system for an active agent delivery device. The device comprises an elongate tubular member having first and second ends and a mixing system. The mixing system enables the entire dose of active agent to be entrained in a liquid. In use, liquid is drawn into the first end of the device, the mixing system mixes the liquid and active agent within the device and the active agent entrained in the liquid is drawn out of the second end of the member and into the patient's mouth.
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公开(公告)号：US06224908B1
公开(公告)日：2001-05-01
申请号：US09577041
申请日：2000-05-24
申请人： Patrick S.-L. Wong , Vincent J. Ferrari , Jeffrey W. Etter , Miriam A. Martin , Nathan Roth , Christopher M. G. Ohms , Andrew I. Poutiatine , James Horvath
发明人： Patrick S.-L. Wong , Vincent J. Ferrari , Jeffrey W. Etter , Miriam A. Martin , Nathan Roth , Christopher M. G. Ohms , Andrew I. Poutiatine , James Horvath
IPC分类号： A61K924
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0092
摘要： Oral active agent delivery system having improved flow controllers. A hollow tubular member containing the active agent formulation and having a fluid passing controller is placed at one end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.
摘要翻译： 具有改进的流量控制器的口服活性剂递送系统。 含有活性剂制剂并具有流体通过控制器的空心管状构件一端放置在流体中，并在第二端放入患者口中。 当患者唾液在腔室的末端时，递送活性剂。 改进的控制器防止活性剂制剂的泄漏。
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公开(公告)号：US06183466B2
公开(公告)日：2001-02-06
申请号：US09344811
申请日：1999-06-25
IPC分类号： A61K948
CPC分类号： A61K9/4808 , A61K9/0004
摘要： A dosage form is disclosed comprising a wall that defines an injection-molded compartment housing a capsule comprising a drug formulation.
摘要翻译： 公开了一种剂型，其包含壁，其限定容纳包含药物制剂的胶囊的注射模制隔室。
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5.发明授权Osmotic device with high drug loading and delayed activation of drug delivery 失效渗透装置具有高药物负荷和药物递送延迟激活
公开(公告)号：US5817335A
公开(公告)日：1998-10-06
申请号：US451647
申请日：1995-05-26
CPC分类号： A61K9/0004 , Y10S514/962
摘要： The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation being of a predetermined length of time. The dispensing device is formed of a first and second housing that are in reversibly sliding telescoping arrangement with each other. The first housing contains the active agent formulation and has an aspect ratio less than 1. The housings are preferably. ovoloid in shape.
摘要翻译： 本发明涉及一种流体吸收药物递送装置，其用于将活性剂制剂初始延迟递送至使用的流体环境，起始或启动的初始延迟时间为预定时间长度。 分配装置由彼此可逆地滑动伸缩布置的第一和第二壳体形成。 第一壳体包含活性剂制剂并且具有小于1的纵横比。该外壳是优选的。 ovoloid形状。
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公开(公告)号：US06595951B1
公开(公告)日：2003-07-22
申请号：US09575074
申请日：2000-05-19
申请人： Patrick S. -L. Wong , James Horvath , Radomir N. M. Vukadin , Joyce C. Anthony , Vincent J. Ferrari , Jeffrey W. Etter , Christopher M. G. Ohms
发明人： Patrick S. -L. Wong , James Horvath , Radomir N. M. Vukadin , Joyce C. Anthony , Vincent J. Ferrari , Jeffrey W. Etter , Christopher M. G. Ohms
IPC分类号： A61M3700
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0092
摘要： The present invention is directed to a closure system for an oral active agent delivery device. The device comprises an elongate tubular member having first and second ends. The closure system includes a deformable closure means adapted to allow delivery of the active agent upon deformation. The closure system prevents spillage and maintains the integrity of the dose within the device. In use, the closure system is deformed and separated from the second end of the tubular member, liquid is drawn up into the first end of the member, and the liquid and active agent are drawn out of the second end of the member and into the patient's mouth.
摘要翻译： 本发明涉及用于口服活性剂递送装置的封闭系统。 该装置包括具有第一端和第二端的细长管状构件。 闭合系统包括适于允许活化剂在变形时输送的可变形闭合装置。 闭合系统防止溢出并维持装置内剂量的完整性。 在使用中，封闭系统变形并与管状构件的第二端分离，液体被拉入构件的第一端，并且液体和活性剂从构件的第二端被拉出并进入 病人的嘴。
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公开(公告)号：US6153678A
公开(公告)日：2000-11-28
申请号：US167372
申请日：1998-10-06
申请人： Liang-Chang Dong , Crystal Pollock , Patrick S.-L. Wong , Keru O. Shafi , Vincent J. Ferrari , Ted Smith
发明人： Liang-Chang Dong , Crystal Pollock , Patrick S.-L. Wong , Keru O. Shafi , Vincent J. Ferrari , Ted Smith
CPC分类号： C08L71/02 , A61K9/0004 , C08L67/04
摘要： Polymeric compositions are disclosed comprising a poly(caprolactone), a poly(alkylene oxide), a poly(oxyethylenated fatty acid ester), or a poly(oxyethylenated fatty acid), or a poly(oxyethylene-co-oxypropylene).
摘要翻译： 公开了包含聚（己内酯），聚（环氧烷），聚（氧乙烯化脂肪酸酯）或聚（氧乙烯化脂肪酸）或聚（氧乙烯 - 共 - 氧丙烯）的聚合物组合物。
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公开(公告)号：US6103265A
公开(公告)日：2000-08-15
申请号：US401610
申请日：1999-09-22
申请人： Patrick S.-L. Wong , Vincent J. Ferrari , Jeffrey W. Etter , Miriam A. Martin , Nathan Roth , Christopher M. G. Ohms , Andrew I. Poutiatine , James Horvath
发明人： Patrick S.-L. Wong , Vincent J. Ferrari , Jeffrey W. Etter , Miriam A. Martin , Nathan Roth , Christopher M. G. Ohms , Andrew I. Poutiatine , James Horvath
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0092
摘要： The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.
摘要翻译： 本发明涉及包含改进的流量控制器的口服活性剂递送系统。 含有活性剂制剂并具有流体通过控制器（14）的中空管状构件（10）在一端（16）处放置成流体，并在第二端（18）放置到患者口中。 当患者唾液在腔室的末端时，递送活性剂。 改进的控制器防止活性剂制剂的泄漏。
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公开(公告)号：US5614578A
公开(公告)日：1997-03-25
申请号：US330892
申请日：1994-10-28
IPC分类号： A61K9/00 , A61K9/20 , A61K47/34 , A61K47/38 , B01D71/48 , C08L1/28 , C08L67/04 , C08L71/02 , C08K5/06
CPC分类号： C08L67/04 , A61K47/34 , A61K47/38 , A61K9/0004 , A61K9/2095 , B01D71/48 , C08L71/02 , C08L1/284
摘要： A dosage form is disclosed comprising an injection-molded housing member free of organic solvents.
摘要翻译： 公开了一种剂型，其包括不含有机溶剂的注塑外壳构件。
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公开(公告)号：US6096003A
公开(公告)日：2000-08-01
申请号：US950016
申请日：1997-10-14
申请人： Patrick S.-L. Wong , James Horvath , Radomir N. M. Vukadin , Joyce C. Anthony , Vincent J. Ferrari , Jeffrey W. Etter , Christopher M. G. Ohms
发明人： Patrick S.-L. Wong , James Horvath , Radomir N. M. Vukadin , Joyce C. Anthony , Vincent J. Ferrari , Jeffrey W. Etter , Christopher M. G. Ohms
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0092
摘要： The present invention is directed to a closure system for an oral active agent delivery device. The device comprises an elongate tubular member having first and second ends. The closure system includes a deformable closure means adapted to allow delivery of the active agent upon deformation. The closure system prevents spillage and maintains the integrity of the dose within the device. In use, the closure system is deformed and separated from the second end of the tubular member, liquid is drawn up into the first end of the member, and the liquid and active agent are drawn out of the second end of the member and into the patient's mouth.
摘要翻译： 本发明涉及用于口服活性剂递送装置的封闭系统。 该装置包括具有第一端和第二端的细长管状构件。 闭合系统包括适于允许活化剂在变形时输送的可变形闭合装置。 闭合系统防止溢出并维持装置内剂量的完整性。 在使用中，封闭系统变形并与管状构件的第二端分离，液体被拉入构件的第一端，并且液体和活性剂从构件的第二端被拉出并进入 病人的嘴。
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