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1.发明授权Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging 失效用于制备用于医学成像的含氟碳聚合物壳的方法
公开(公告)号：US5505932A
公开(公告)日：1996-04-09
申请号：US478986
申请日：1995-06-06
申请人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
发明人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
CPC分类号： A61K49/223 , A61K47/48853 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1806 , A61K49/186 , A61K49/1863 , A61K49/1869 , A61K49/222 , Y10S436/806 , Y10T436/24
摘要： In accordance with the present invention, compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
摘要翻译： 根据本发明，提供了包含聚合物壳内的成像剂的组合物。 本发明组合物可用作例如磁共振成像（MRI），超声检查和X射线计算机断层摄影的造影剂。 聚合物外壳直径通常为约2微米。 因此，这些材料由于网状上游系统（RES）或单核吞噬细胞（MNP）系统在静脉注射后迅速清除而具有器官特异性。 此外，本发明的聚合物壳可用于测量和监测局部氧气和温度。 考虑用于本发明实践的示例性造影剂包括氟化合物。 氟化合物通常是疏水性的，因此具有有限的水溶性。 本发明方法允许以适于准备输送的生物相容形式制备这些化合物。
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2.发明授权Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor 失效用于体内递送基本上不溶于水的药理学活性剂及其有用的组合物的方法
公开(公告)号：US5439686A
公开(公告)日：1995-08-08
申请号：US23698
申请日：1993-02-22
申请人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Mark W. Grinstaff , Kenneth S. Suslick
发明人： Neil P. Desai , Patrick Soon-Shiong , Paul A. Sandford , Mark W. Grinstaff , Kenneth S. Suslick
CPC分类号： A61K9/0026 , A23L33/40 , A61K47/48869 , A61K47/48876 , A61K49/0002 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug taxol) in which the pharmacologically active agent is delivered in a soluble form or in the form of suspended particles. In particular, the soluble form may comprise a solution of pharmacologically active agent in a biocompatible dispersing agent contained within a protein walled shell. Alternatively, the protein walled shell may contain particles of taxol. In another aspect, the suspended form comprises particles of pharmacologically active agent in a biocompatible aqueous liquid.
摘要翻译： 根据本发明，提供了用于体内递送基本上不溶于水的药理活性剂（例如抗癌药物紫杉醇）的组合物，其中药理活性剂以可溶形式或以悬浮颗粒的形式递送 。 特别地，可溶形式可以包含药物活性剂在包含在蛋白质壁壳中的生物相容性分散剂中的溶液。 或者，蛋白质壁壳可以含有紫杉醇颗粒。 在另一方面，悬浮形式包括生物相容性水性液体中的药理活性剂颗粒。
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3.发明授权
公开(公告)号：US5665383A
公开(公告)日：1997-09-09
申请号：US488804
申请日：1995-06-07
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
CPC分类号： A61K47/48876 , A23L33/40 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/0026 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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公开(公告)号：US5508021A
公开(公告)日：1996-04-16
申请号：US326116
申请日：1994-10-19
申请人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
发明人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
IPC分类号： A61K9/00 , A61K9/50 , A61K9/51 , A61K47/48 , A61K49/18 , A61K49/22 , A61B5/055 , A61B8/13 , A61K49/04
CPC分类号： A61K49/223 , A61K47/48853 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1806 , A61K49/186 , A61K49/1863 , A61K49/1869 , A61K49/222 , Y10S436/806 , Y10T436/24
摘要： In accordance with the present invention compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
摘要翻译： 根据本发明，提供了包含聚合物壳内的成像剂的组合物。 本发明组合物可用作例如磁共振成像（MRI），超声检查和X射线计算机断层摄影的造影剂。 聚合物外壳直径通常为约2微米。 因此，这些材料由于网状上游系统（RES）或单核吞噬细胞（MNP）系统在静脉注射后迅速清除而具有器官特异性。 此外，本发明的聚合物壳可用于测量和监测局部氧气和温度。 考虑用于本发明实践的示例性造影剂包括氟化合物。 氟化合物通常是疏水性的，因此具有有限的水溶性。 本发明方法允许以适于准备输送的生物相容形式制备这些化合物。
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5.发明授权Composition useful for in vivo delivery of biologics and methods employing same 失效可用于体内递送生物制剂的组合物和使用其的方法
公开(公告)号：US5498421A
公开(公告)日：1996-03-12
申请号：US200235
申请日：1994-02-22
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
IPC分类号： A23L33/00 , A61K9/00 , A61K9/50 , A61K9/51 , A61K47/30 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00 , A61K38/00 , A61K9/127
CPC分类号： A61K9/0026 , A23L33/40 , A61K47/48869 , A61K47/48876 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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6.发明授权Polymeric shells for medical imaging prepared from synthetic polymers, and methods for the use thereof 失效由合成聚合物制备的用于医学成像的聚合物壳及其使用方法
公开(公告)号：US5512268A
公开(公告)日：1996-04-30
申请号：US486268
申请日：1995-06-06
申请人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
发明人： Mark W. Grinstaff , Neil P. Desai , Kenneth S. Suslick , Patrick Soon-Shiong , Paul A. Sandford , Noma R. Merideth
IPC分类号： A61K9/00 , A61K9/50 , A61K9/51 , A61K47/48 , A61K49/18 , A61K49/22 , A61B5/055 , A61B8/13 , A61K49/04
CPC分类号： A61K49/223 , A61K47/48853 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1806 , A61K49/186 , A61K49/1863 , A61K49/1869 , A61K49/222 , Y10S436/806 , Y10T436/24
摘要： In accordance with the present invention, compositions comprising imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography. The polymeric shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, polymeric shells of the invention can be used to measure and monitor local oxygen and temperature. Exemplary contrast agents contemplated for use in the practice of the present invention include fluorinated compounds. Fluorinated compounds in general are hydrophobic and as such have limited water solubility. The invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery.
摘要翻译： 根据本发明，提供了包含聚合物壳内的成像剂的组合物。 本发明组合物可用作例如磁共振成像（MRI），超声检查和X射线计算机断层摄影的造影剂。 聚合物外壳直径通常为约2微米。 因此，这些材料由于网状上游系统（RES）或单核吞噬细胞（MNP）系统在静脉注射后迅速清除而具有器官特异性。 此外，本发明的聚合物壳可用于测量和监测局部氧气和温度。 考虑用于本发明实践的示例性造影剂包括氟化合物。 氟化合物通常是疏水性的，因此具有有限的水溶性。 本发明方法允许以适于准备输送的生物相容形式制备这些化合物。
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公开(公告)号：US5639473A
公开(公告)日：1997-06-17
申请号：US483295
申请日：1995-06-07
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
IPC分类号： A23L33/00 , A61K9/00 , A61K9/50 , A61K9/51 , A61K47/30 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00 , A61K9/127
CPC分类号： A61K9/0026 , A23L33/40 , A61K47/48869 , A61K47/48876 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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公开(公告)号：US5560933A
公开(公告)日：1996-10-01
申请号：US412726
申请日：1995-03-29
申请人： Patrick Soon-Shiong , Neil P. Desai , Mark W. Grinstaff , Paul A. Sandford , Kenneth S. Suslick
发明人： Patrick Soon-Shiong , Neil P. Desai , Mark W. Grinstaff , Paul A. Sandford , Kenneth S. Suslick
CPC分类号： A61K9/0026 , A23L33/40 , A61K47/48869 , A61K47/48876 , A61K49/0002 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug taxol) in which the pharmacologically active agent is delivered in a soluble form or in the form of suspended particles. In particular, the soluble form may comprise a solution of pharmacologically active agent in a biocompatible dispersing agent contained within a protein walled shell. Alternatively, the protein walled shell may contain particles of taxol. In another aspect, the suspended form comprises particles of pharmacologically active agent in a biocompatible aqueous liquid.
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9.发明授权Methods for the preparation of pharmaceutically active agents for in vivo delivery 失效用于制备用于体内递送的药物活性剂的方法
公开(公告)号：US5665382A
公开(公告)日：1997-09-09
申请号：US485448
申请日：1995-06-07
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
CPC分类号： A61K47/48876 , A23L33/40 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/0026 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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10.发明授权Methods for in vivo delivery of nutriceuticals and compositions useful therefor 失效用于体内递送营养物质和用于其的组合物的方法
公开(公告)号：US5650156A
公开(公告)日：1997-07-22
申请号：US482272
申请日：1995-06-07
申请人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
发明人： Mark W. Grinstaff , Patrick Soon-Shiong , Michael Wong , Paul A. Sandford , Kenneth S. Suslick , Neil P. Desai
CPC分类号： A61K47/48876 , A23L33/40 , A61K47/48869 , A61K49/126 , A61K49/18 , A61K49/1818 , A61K49/1863 , A61K49/222 , A61K49/223 , A61K49/226 , A61K9/0026 , A61K9/5052 , A61K9/5138 , A61K9/5146 , A61K9/5161 , A61K9/5169 , B82Y5/00
摘要： In accordance with the present invention, there are provided compositions useful for the in vivo delivery of a biologic, wherein the biologic is associated with a polymeric shell formulated from a biocompatible material. The biologic can be associated with the polymeric shell itself, and/or the biologic, optionally suspended/dispersed in a biocompatible dispersing agent, can be encased by the polymeric shell. In another aspect, the biologic associated with polymeric shell is administered to a subject, optionally dispersed in a suitable biocompatible liquid.
摘要翻译： 根据本发明，提供了可用于生物体的体内递送的组合物，其中生物体与由生物相容性材料配制的聚合物壳相关联。 生物体可以与聚合物壳本身相关联，和/或任选地悬浮/分散在生物相容性分散剂中的生物物质可以被聚合物壳包裹。 在另一方面，将与聚合物壳相关的生物体施用于受试者，任选地分散在合适的生物相容性液体中。
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