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    Vaccination Regimen for B-Cell Vaccines
    2.
    发明申请
    Vaccination Regimen for B-Cell Vaccines 审中-公开
    B细胞疫苗接种方案

    公开(公告)号：US20100119540A1

    公开(公告)日：2010-05-13

    申请号：US12594650

    申请日：2008-04-18

    申请人： Martin Bachmann ,  Patrik Maurer ,  Philipp Muller ,  Thomas Pfister ,  Wolfgang Renner

    发明人： Martin Bachmann ,  Patrik Maurer ,  Philipp Muller ,  Thomas Pfister ,  Wolfgang Renner

    IPC分类号： A61K39/385

    CPC分类号： A61K39/0013 ,  A61K47/646 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55505

    摘要： This invention relates to the field of vaccination and treatment or prevention diseases. In particular this invention relates to the treatment or prevention of diseases by inducing hapten-specific antibody responses in a vaccinated subject. The invention further provides a method for prevention or treatment of a disease by inducing hapten-specific antibodies in a subject comprising administering into said subject a composition comprising a virus-like particle of an RNA bacteriophage and at least one hapten linked thereto.

    摘要翻译： 本发明涉及疫苗接种和治疗或预防疾病领域。 特别地，本发明涉及通过在接种疫苗的受试者中诱导半抗原特异性抗体应答来治疗或预防疾病。 本发明还提供了通过在受试者中诱导半抗原特异性抗体来预防或治疗疾病的方法，所述方法包括向所述受试者施用包含RNA噬菌体的病毒样颗粒和至少一种与其连接的半抗原的组合物。

    Parenteral bisphosphonate composition with improved local tolerance
    3.
    发明授权
    Parenteral bisphosphonate composition with improved local tolerance 有权
    肠胃外二膦酸盐组合物具有改善的局部耐受性

    公开(公告)号：US06677320B2

    公开(公告)日：2004-01-13

    申请号：US09758605

    申请日：2001-01-11

    申请人： Anke Diederich ,  Pierre Goldbach ,  Thomas Pfister

    发明人： Anke Diederich ,  Pierre Goldbach ,  Thomas Pfister

    IPC分类号： A61K3166

    CPC分类号： A61K47/18 ,  A61K9/0019 ,  A61K31/66 ,  A61K31/663 ,  A61K47/183

    摘要： The present invention relates to a parenteral composition comprising a bisphosphonic acid or a pharmaceutically acceptable salt thereof (bisphosphonate) as active component and a pharmaceutically acceptable chelating agent, processes of the preparation of this composition, and methods of their use in the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, hypercalcemia of malignancy, and metabolic bone disease. The compositions are especially useful for improving the local tolerance of the active component when administered parenterally.

    摘要翻译： 本发明涉及包含双膦酸或其药学上可接受的盐（二膦酸盐）作为活性成分和药学上可接受的螯合剂的肠胃外组合物，该组合物的制备方法及其用于治疗和预防 涉及骨吸收的疾病，特别是骨质疏松症，佩吉特氏病，恶性高钙血症和代谢性骨病。 当肠胃外给药时，组合物特别可用于改善活性成分的局部耐受性。