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公开(公告)号:US4235868A
公开(公告)日:1980-11-25
申请号:US11666
申请日:1979-02-12
申请人: Michael J. Cleare , Paul C. Hydes
发明人: Michael J. Cleare , Paul C. Hydes
IPC分类号: C01B21/08 , C01B21/092 , C01C3/20 , C12Q1/68 , G01N1/30
CPC分类号: C01B21/092 , C01B21/08 , C01C3/20 , C12Q1/68
摘要: This invention relates to the staining of cells, and in particular provides a novel reagent for the detection, for example, of DNA (deoxyribonucleic acid) and polysaccharides by electron microscopy.A reagent for staining cells in accordance with the present invention comprises an aqueous solution of a nitrido-bridged complex of osmium or ruthenium and having the general formula:[M.sub.2.sup.IV N(NH.sub.3).sub.8-2x X.sub.5-y (H.sub.2 O).sub.x ]Y.sub.y.where M represents either Os or Ru, X and Y are the same or different anions selected from nitrate, halide and pseudohalide, x is 0 or 1 and y is 2 or 3.
摘要翻译: 本发明涉及细胞的染色,特别是提供了用于通过电子显微镜检测例如DNA(脱氧核糖核酸)和多糖的新型试剂。 根据本发明的用于染色细胞的试剂包含锇或钌的硝基桥接复合物的水溶液,并具有以下通式:[M2IVN(NH3)8-2xX5-y(H2O)x] Yy。 其中M表示Os或Ru,X和Y是选自硝酸盐,卤化物和拟卤化物的相同或不同的阴离子,x为0或1,y为2或3。
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公开(公告)号:US4148870A
公开(公告)日:1979-04-10
申请号:US905791
申请日:1978-05-15
申请人: Paul C. Hydes , Michael J. Cleare
发明人: Paul C. Hydes , Michael J. Cleare
IPC分类号: C07D217/02 , C07D237/08 , C07D237/30 , C07D453/02 , C07D487/08 , C07F15/00 , G01N1/00 , G01N1/28 , G01N1/30
CPC分类号: C07D487/08 , C07D217/02 , C07D237/08 , C07D237/30 , C07D453/02 , C07F15/0026
摘要: This specification describes a complex of osmium tetroxide and a compound having a heterocyclic ring containing one or two tertiary nitrogen atoms. The compound may be an aromatic tertiary amine and the tertiary nitrogen atom may be the sole heterocyclic atom in the heterocyclic ring. The complexes described are suitable for fixing and staining cells and may be used in the preparation of biological specimens for examination by electron microscopy.
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公开(公告)号:US4952676A
公开(公告)日:1990-08-28
申请号:US193097
申请日:1988-07-20
CPC分类号: C07F15/0093 , A61K47/48384 , Y10S514/885 , Y10S530/808
摘要: A platinum co-ordination compound linkable to a monoclonal antibody by a functional group which forms part of a moiety which stabilizes the antibody against in vivo hydrolysis. Also the use of such compounds in the treatment of cancer.
摘要翻译: 可通过官能团与单克隆抗体相连的铂配位化合物,该官能团形成部分稳定抗体以抵抗体内水解的部分。 还可以使用这些化合物治疗癌症。
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公开(公告)号:US4760156A
公开(公告)日:1988-07-26
申请号:US873131
申请日:1986-06-11
IPC分类号: G01N33/574 , A61K39/395 , A61K47/48 , C07D317/30 , C07F15/00 , C12P21/08 , G01N33/577
CPC分类号: C07F15/0093 , A61K47/48384
摘要: A platinum co-ordination compound linkable to a monoclonal antibody by a functional group which forms part of a moiety which stabilises the antibody against in vivo hydrolysis. Also the use of such compounds in the treatment of cancer.
摘要翻译: 可通过官能团与单克隆抗体相连的铂配位化合物,该官能团形成部分稳定抗体以抵抗体内水解的部分。 还可以使用这些化合物治疗癌症。
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公开(公告)号:US4657927A
公开(公告)日:1987-04-14
申请号:US497806
申请日:1983-05-25
CPC分类号: C07F15/0093 , C07C55/02
摘要: Malonato platinum coordination compounds and a method of treating malignant tumors sensitive to a planar dsp.sup.2 platinum (II) coordination compound or an octahedral d.sup.2 sp.sup.3 platinum (IV) coordination compound comprising the parenteral administration to an affected animal of a solution of the compound.
摘要翻译: 丙二酸铂配位化合物和治疗对平面dsp2铂(II)配位化合物或八面体d2sp3铂(IV)配位化合物敏感的恶性肿瘤的方法,包括向受影响的动物施用化合物溶液。
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公开(公告)号:US4140707A
公开(公告)日:1979-02-20
申请号:US778955
申请日:1977-03-18
IPC分类号: A61K31/28 , A61K31/282 , A61P35/00 , C07F15/00
CPC分类号: C07F15/0093
摘要: Malonato platinum coordination compounds and a method of treating malignant tumors comprising the parenteral administration to an affected animal of a solution of the compound.
摘要翻译: 丙二酸铂配位化合物和治疗恶性肿瘤的方法,包括向受影响的动物肠胃外给药该化合物的溶液。
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