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公开(公告)号：US09220403B2
公开(公告)日：2015-12-29
申请号：US13814677
申请日：2011-08-12
IPC分类号： A61B3/10 , A61B3/00 , A61B3/14 , A61B3/117 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B3/11 , A61B3/135
CPC分类号： A61B5/14546 , A61B3/0008 , A61B3/1005 , A61B3/107 , A61B3/111 , A61B3/117 , A61B3/1173 , A61B3/135 , A61B5/0068 , A61B5/0071 , A61B5/1455 , A61B5/4088 , A61B5/6821 , A61B2562/0238 , A61B2562/0242
摘要： In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
摘要翻译： 根据本发明的一个实施方案，提供了用于检测哺乳动物眼睛中淀粉样蛋白质的装置和方法。 一种方法包括用具有波长特性，极化性质或其组合中的至少一种的光源照射眼睛，当淀粉样蛋白结合化合物与 淀粉样蛋白，已经引入到眼睛中的淀粉样蛋白结合化合物与指示淀粉样变性疾病的淀粉样蛋白特异性结合; 以及确定至少由与淀粉样蛋白结合的淀粉样蛋白结合化合物产生的荧光的荧光的时间衰减速率，所述确定允许基于在...的区别在眼睛中结合到淀粉样蛋白的淀粉样蛋白结合化合物的存在 时间衰减率最小。
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公开(公告)号：US20130135580A1
公开(公告)日：2013-05-30
申请号：US13814677
申请日：2011-08-12
CPC分类号： A61B5/14546 , A61B3/0008 , A61B3/1005 , A61B3/107 , A61B3/111 , A61B3/117 , A61B3/1173 , A61B3/135 , A61B5/0068 , A61B5/0071 , A61B5/1455 , A61B5/4088 , A61B5/6821 , A61B2562/0238 , A61B2562/0242
摘要： In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
摘要翻译： 根据本发明的一个实施方案，提供了用于检测哺乳动物眼睛中淀粉样蛋白质的装置和方法。 一种方法包括用具有波长特性，极化性质或其组合中的至少一种的光源照射眼睛，当淀粉样蛋白结合化合物与 淀粉样蛋白，已经引入到眼睛中的淀粉样蛋白结合化合物与指示淀粉样变性疾病的淀粉样蛋白特异性结合; 以及确定至少由与淀粉样蛋白结合的淀粉样蛋白结合化合物产生的荧光的荧光的时间衰减速率，所述确定允许基于在...的区别在眼睛中结合到淀粉样蛋白的淀粉样蛋白结合化合物的存在 时间衰减率最小。
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公开(公告)号：US08955969B2
公开(公告)日：2015-02-17
申请号：US12933591
申请日：2009-03-27
申请人： Paul D. Hartung , Vincent Valvo , Dennis J. Nilan
发明人： Paul D. Hartung , Vincent Valvo , Dennis J. Nilan
摘要： A system for performing at least one of quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and received from the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye.
摘要翻译： 用于对受试者的眼睛进行准弹性光散射和荧光配体扫描中的至少一种的系统包括：被配置为朝向被检者的眼睛发射光的光源;被配置为聚焦从源发送并从受检者眼睛接收的光的透镜 设置成接收聚焦光的至少一部分并被配置为反射所接收的光的第一部分的测量反射器，配置和设置成接收所接收的光的第一部分并被配置为提供对应于图像的图像的标记的照相机 耦合到相机并且被配置为分析图像中的光的强度以确定与眼睛的一部分的界面相对应的参考点的位置的处理器。
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公开(公告)号：US20110116041A1
公开(公告)日：2011-05-19
申请号：US12933591
申请日：2009-03-27
申请人： Paul D. Hartung , Vincent Valvo , Dennis J. Nilan
发明人： Paul D. Hartung , Vincent Valvo , Dennis J. Nilan
摘要： A system for performing at least one of quasi-elastic light scattering and fluorescent ligand scanning on a subject's eye includes a light source configured to transmit light toward the subject's eye, a lens configured to focus light sent from the source and received from the subject's eye, a measurement reflector disposed to receive at least a portion of the focused light and configured to reflect a first portion of the received light, a camera configured and disposed to receive the first portion of the received light and configured to provide indicia of an image corresponding to the first portion of the received light, and a processor coupled to the camera and configured to analyze intensities of light in the image to determine a location of a reference point corresponding to an interface of a portion of the eye.
摘要翻译： 用于对受试者的眼睛进行准弹性光散射和荧光配体扫描中的至少一种的系统包括：被配置为朝向被检者的眼睛发射光的光源;被配置为聚焦从源发送并从受检者眼睛接收的光的透镜 设置成接收聚焦光的至少一部分并被配置为反射所接收的光的第一部分的测量反射器，配置和设置成接收所接收的光的第一部分并被配置为提供对应于图像的图像的标记的照相机 耦合到相机并且被配置为分析图像中的光的强度以确定与眼睛的一部分的界面相对应的参考点的位置的处理器。
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