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公开(公告)号：US09220403B2
公开(公告)日：2015-12-29
申请号：US13814677
申请日：2011-08-12
IPC分类号： A61B3/10 , A61B3/00 , A61B3/14 , A61B3/117 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B3/11 , A61B3/135
CPC分类号： A61B5/14546 , A61B3/0008 , A61B3/1005 , A61B3/107 , A61B3/111 , A61B3/117 , A61B3/1173 , A61B3/135 , A61B5/0068 , A61B5/0071 , A61B5/1455 , A61B5/4088 , A61B5/6821 , A61B2562/0238 , A61B2562/0242
摘要： In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
摘要翻译： 根据本发明的一个实施方案，提供了用于检测哺乳动物眼睛中淀粉样蛋白质的装置和方法。 一种方法包括用具有波长特性，极化性质或其组合中的至少一种的光源照射眼睛，当淀粉样蛋白结合化合物与 淀粉样蛋白，已经引入到眼睛中的淀粉样蛋白结合化合物与指示淀粉样变性疾病的淀粉样蛋白特异性结合; 以及确定至少由与淀粉样蛋白结合的淀粉样蛋白结合化合物产生的荧光的荧光的时间衰减速率，所述确定允许基于在...的区别在眼睛中结合到淀粉样蛋白的淀粉样蛋白结合化合物的存在 时间衰减率最小。
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公开(公告)号：US20130135580A1
公开(公告)日：2013-05-30
申请号：US13814677
申请日：2011-08-12
CPC分类号： A61B5/14546 , A61B3/0008 , A61B3/1005 , A61B3/107 , A61B3/111 , A61B3/117 , A61B3/1173 , A61B3/135 , A61B5/0068 , A61B5/0071 , A61B5/1455 , A61B5/4088 , A61B5/6821 , A61B2562/0238 , A61B2562/0242
摘要： In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
摘要翻译： 根据本发明的一个实施方案，提供了用于检测哺乳动物眼睛中淀粉样蛋白质的装置和方法。 一种方法包括用具有波长特性，极化性质或其组合中的至少一种的光源照射眼睛，当淀粉样蛋白结合化合物与 淀粉样蛋白，已经引入到眼睛中的淀粉样蛋白结合化合物与指示淀粉样变性疾病的淀粉样蛋白特异性结合; 以及确定至少由与淀粉样蛋白结合的淀粉样蛋白结合化合物产生的荧光的荧光的时间衰减速率，所述确定允许基于在...的区别在眼睛中结合到淀粉样蛋白的淀粉样蛋白结合化合物的存在 时间衰减率最小。
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公开(公告)号：US20120302601A1
公开(公告)日：2012-11-29
申请号：US13514769
申请日：2010-12-09
IPC分类号： A61K31/47 , A61P27/02 , A61K31/423
CPC分类号： A61K31/423 , A61K9/0048 , A61K31/47 , A61K47/40
摘要： The present invention is directed to topical ophthalmic compositions of a lipophilic compound and an oligomeric or polymeric carrier wherein the compositions are useful in the treatment and prevention of macular degeneration. The invention also includes methods of treating macular degeneration by using a topical ophthalmic composition of a lipophilic compound and an oligomeric or polymeric carrier.
摘要翻译： 本发明涉及亲脂性化合物和低聚物或聚合物载体的局部眼用组合物，其中所述组合物可用于治疗和预防黄斑变性。 本发明还包括通过使用亲脂性化合物和低聚物或聚合物载体的局部眼用组合物治疗黄斑变性的方法。
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公开(公告)号：US08080028B2
公开(公告)日：2011-12-20
申请号：US11294618
申请日：2005-12-05
申请人： Gerald D. Cagle
发明人： Gerald D. Cagle
IPC分类号： A61B17/32
CPC分类号： A61B17/3211 , A61B2017/00889 , A61B2017/00893 , A61L31/16 , A61L2300/404 , A61L2300/606
摘要： A surgical knife blade or other surgical device containing an anti-microbial coating. The coating may be adhered to the device by a water-soluble adhesive that allows the anti-microbial coating to be released into the wound track. The coating may be of a consistency that allows a certain amount of the coating to slough off and pool or puddle around the surgical site as the surgical device is moved into and out of the surgical site.
摘要翻译： 手术刀片或其他包含抗微生物涂层的手术装置。 涂层可以通过允许将抗微生物涂层释放到伤口轨道中的水溶性粘合剂粘附到装置上。 涂层可以是一致的，其允许一定量的涂层在外科手术装置移入和移出外科手术部位时脱落并且在手术部位周围聚集或聚集。
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公开(公告)号：US5985259A
公开(公告)日：1999-11-16
申请号：US846406
申请日：1997-04-30
IPC分类号： A61K9/00 , A61K31/496 , A61K31/70 , A61K31/74
CPC分类号： A61K31/496 , A61K9/0048
摘要： An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painfull and potentially traumatic injections of antibiotics by utilizing sustained release compositions which allow the antibiotics contained therein to penetrate deeply into the eye, thereby ensuring a sterile field of surgery during intraocular surgical procedures. The compositions may also be utilized to prevent post-surgical infections.
摘要翻译： 描述了在眼外科手术之前对手术领域进行消毒的改进方法。 本发明通过使用允许其中包含的抗生素深入眼睛的持续释放组合物消除了对抗生素的疼痛和潜在创伤性注射抗生素的需要，从而确保了眼内手术过程中的无菌手术领域。 组合物也可用于预防手术后感染。
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公开(公告)号：US5149694A
公开(公告)日：1992-09-22
申请号：US440546
申请日：1989-11-22
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , Y10S514/912
摘要： Disclosed are pharmaceutical compositions comprising tobramycin and dexamethasone for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for infection and control of inflammatory response for optimal wound healing and normalization of the eye.
摘要翻译： 公开了包含用于局部眼科递送的妥布霉素和地塞米松的药物组合物，以及治疗方法，其包括当指示感染时施用所述组合物并控制炎症反应以获得最佳伤口愈合和眼睛正常化。
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公开(公告)号：US09814701B2
公开(公告)日：2017-11-14
申请号：US13514769
申请日：2010-12-09
IPC分类号： A61K31/47 , A61K47/40 , A61K9/00 , A61K31/423
CPC分类号： A61K31/423 , A61K9/0048 , A61K31/47 , A61K47/40
摘要： The present invention is directed to topical ophthalmic compositions of a lipophilic compound and an oligomeric or polymeric carrier wherein the compositions are useful in the treatment and prevention of macular degeneration. The invention also includes methods of treating macular degeneration by using a topical ophthalmic composition of a lipophilic compound and an oligomeric or polymeric carrier.
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公开(公告)号：US06261547B1
公开(公告)日：2001-07-17
申请号：US09448038
申请日：1999-11-23
申请人： Rajan Bawa , Rex E. Hall , Bhagwati P. Kabra , James E. Teague , Gerald D. Cagle , Kerry L. Markwardt , Mandar V. Shah
发明人： Rajan Bawa , Rex E. Hall , Bhagwati P. Kabra , James E. Teague , Gerald D. Cagle , Kerry L. Markwardt , Mandar V. Shah
IPC分类号： A61K3174
CPC分类号： A61K47/36 , A61K9/0048 , A61K31/5377 , Y10S514/912
摘要： Ophthalmic drug delivery vehicles which are administrable as a liquid and which gel upon contact with the eye are disclosed. The vehicles contain xanthan gum and an ophthalmically acceptable anesthetic agent.
摘要翻译： 公开了可与液体接触并与眼睛接触凝胶的眼药物递送载体。 车辆含有黄原胶和眼科可接受的麻醉剂。
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9.发明授权Use of sustained release antibiotic compositions in ophthalmic surgical procedures 失效缓释抗生素组合物在眼科手术中的应用公开(公告)号：US06630135B1
公开(公告)日：2003-10-07
申请号：US09438987
申请日：1999-11-12
IPC分类号： A61K3170
CPC分类号： A61K31/496 , A61K9/0048
摘要： An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of antibiotics by utilizing sustained release compositions which allow the antibiotics contained therein to penetrate deeply into the eye, thereby ensuring a sterile field of surgery during intraocular surgical procedures. The compositions may also be utilized to prevent post-surgical infections.
摘要翻译： 描述了在眼外科手术之前对手术领域进行消毒的改进方法。 本发明通过使用允许其中包含的抗生素深入眼睛的持续释放组合物消除了对抗生素疼痛和潜在创伤性注射抗生素的需要，从而确保了眼内手术过程中的无菌手术领域。 组合物也可用于预防手术后感染。
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10.发明授权Use of sustained release antibiotic compositions in ophthalmic surgical procedures 失效缓释抗生素组合物在眼科手术中的应用
公开(公告)号：US5631004A
公开(公告)日：1997-05-20
申请号：US129924
申请日：1993-09-30
IPC分类号： A61K9/00 , A61K31/496 , A61K31/70 , A61K31/74
CPC分类号： A61K31/496 , A61K9/0048
摘要： An improved method of sterilizing the field of surgery prior to an ophthalmic surgical procedure is described. The invention eliminates the need for painful and potentially traumatic injections of antibiotics by utilizing sustained release compositions which allow the antibiotics contained therein to penetrate deeply into the eye, thereby ensuring a sterile field of surgery during intraocular surgical procedures. The compositions may also be utilized to prevent post-surgical infections.
摘要翻译： 描述了在眼外科手术之前对手术领域进行消毒的改进方法。 本发明通过使用允许其中包含的抗生素深入眼睛的持续释放组合物消除了对抗生素疼痛和潜在创伤性注射抗生素的需要，从而确保了眼内手术过程中的无菌手术领域。 组合物也可用于预防手术后感染。
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