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    THIENOPYRIMIDINE DERIVATIVES AS P13K INHIBITORS
    4.
    发明申请
    THIENOPYRIMIDINE DERIVATIVES AS P13K INHIBITORS 失效
    作为P13K抑制剂的三硝基嘧啶衍生物

    公开(公告)号：US20110021496A1

    公开(公告)日：2011-01-27

    申请号：US12739435

    申请日：2008-10-27

    申请人： Timothy Colin Hancox ,  Neil Anthony Pegg ,  Alan John Nadin ,  Stephen Price

    发明人： Timothy Colin Hancox ,  Neil Anthony Pegg ,  Alan John Nadin ,  Stephen Price

    IPC分类号： A61K31/5377 ,  C07D413/14 ,  A61K31/397

    CPC分类号： C07D495/04 ,  C07D519/00

    摘要： Thienopyrimidines of formula (I) wherein W and R1 to R4 are as defined in the claims, and the pharmaceutically acceptable salts thereof are inhibitors of PI3K and are selective for the p110δ isoform, which is a class Ia PI3 kinase, over both other class Ia and class Ib kinases. The compounds may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

    摘要翻译： 其中W和R 1至R 4如权利要求中所定义的式（I）的噻吩并嘧啶及其药学上可接受的盐是PI3K的抑制剂，并且对于作为Ia类PI3激酶的p110δ同种型，对于其它Ia类 和1b类激酶。 所述化合物可用于治疗与PI3激酶例如癌症，免疫疾病，心血管疾病，病毒感染，炎症，代谢/内分泌功能障碍和神经障碍相关的异常细胞生长，功能或行为引起的疾病和障碍。

    Thienopyrimidine derivatives as P13K inhibitors
    7.
    发明授权
    Thienopyrimidine derivatives as P13K inhibitors 失效
    噻吩并嘧啶衍生物作为P13K抑制剂

    公开(公告)号：US08293735B2

    公开(公告)日：2012-10-23

    申请号：US12739435

    申请日：2008-10-27

    申请人： Timothy Colin Hancox ,  Neil Anthony Pegg ,  Alan John Nadin ,  Stephen Price

    发明人： Timothy Colin Hancox ,  Neil Anthony Pegg ,  Alan John Nadin ,  Stephen Price

    IPC分类号： A61K31/535 ,  C07D413/14

    CPC分类号： C07D495/04 ,  C07D519/00

    摘要： Thienopyrimidines of formula (I) wherein W and R1 to R4 are as defined in the claims, and the pharmaceutically acceptable salts thereof are inhibitors of PI3K and are selective for the p110δ isoform, which is a class Ia PI3 kinase, over both other class Ia and class Ib kinases. The compounds may be used to treat diseases and disorders arising from abnormal cell growth, function or behavior associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

    摘要翻译： 其中W和R 1至R 4如权利要求中所定义的式（I）的噻吩并嘧啶及其药学上可接受的盐是PI3K的抑制剂，并且对于作为Ia类PI3激酶的p110δ同种型，对于其它1a类 和1b类激酶。 该化合物可用于治疗与PI3激酶例如癌症，免疫疾病，心血管疾病，病毒感染，炎症，代谢/内分泌功能障碍和神经障碍相关的异常细胞生长，功能或行为引起的疾病和障碍。