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47 条记录 (耗时 0.03 秒)

    Disubstituted azepan orexin receptor antagonists
    1.
    发明授权
    Disubstituted azepan orexin receptor antagonists 有权
    二取代的azepan orexin受体拮抗剂

    公开(公告)号：US08623863B2

    公开(公告)日：2014-01-07

    申请号：US13125174

    申请日：2009-10-15

    申请人： Paul J. Coleman ,  Mark E. Fraley ,  John D. Schreier

    发明人： Paul J. Coleman ,  Mark E. Fraley ,  John D. Schreier

    IPC分类号： A61K31/55 ,  A61P43/00 ,  C07D223/12

    CPC分类号： C07D223/12 ,  C07D401/14 ,  C07D403/10 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14

    摘要： The present invention is directed to disubstituted azepan and oxazepan amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的二取代氮杂环庚烷和氧氮杂环酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

    Amidoethylthioether Orexin Receptor Antagonists
    6.
    发明申请
    Amidoethylthioether Orexin Receptor Antagonists 审中-公开
    酰胺乙硫醚矿物蛋白受体拮抗剂

    公开(公告)号：US20090105318A1

    公开(公告)日：2009-04-23

    申请号：US12225375

    申请日：2007-03-27

    申请人： Paul J. Coleman ,  John D. Schreier

    发明人： Paul J. Coleman ,  John D. Schreier

    IPC分类号： A61K31/427 ,  C07D417/12 ,  A61K31/4192 ,  C07D403/12 ,  A61P25/20

    CPC分类号： C07D403/12 ,  C07D417/12

    摘要： The present invention is directed to amidoethylthioether compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲肽受体的拮抗剂的酰氨基乙硫醚化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

    Pyridyl piperidine orexin receptor antagonists
    7.
    发明授权
    Pyridyl piperidine orexin receptor antagonists 有权
    吡啶基哌啶食欲素受体拮抗剂

    公开(公告)号：US08569311B2

    公开(公告)日：2013-10-29

    申请号：US13568242

    申请日：2012-08-07

    申请人： Michael J. Breslin ,  Paul J. Coleman ,  Christopher D. Cox ,  John D. Schreier

    发明人： Michael J. Breslin ,  Paul J. Coleman ,  Christopher D. Cox ,  John D. Schreier

    IPC分类号： C07D401/14 ,  A61K31/4525

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

    摘要： The present invention is directed to pyridyl piperidine compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的吡啶基哌啶化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

    Alkoxy tetrahydro-pyridopyrimidine PDE10 inhibitors
    8.
    发明授权
    Alkoxy tetrahydro-pyridopyrimidine PDE10 inhibitors 失效
    烷氧基四氢 - 吡啶并嘧啶PDE10抑制剂

    公开(公告)号：US08492392B2

    公开(公告)日：2013-07-23

    申请号：US13320038

    申请日：2010-05-24

    申请人： Michael J. Breslin ,  Paul J. Coleman ,  Christopher D. Cox ,  Izzat T. Raheem ,  John D. Schreier

    发明人： Michael J. Breslin ,  Paul J. Coleman ,  Christopher D. Cox ,  Izzat T. Raheem ,  John D. Schreier

    IPC分类号： A61K31/519

    CPC分类号： C07D471/04 ,  C07D519/00

    摘要： The present invention is directed to alkoxy tetrahydro-pyridopyrimidine compounds of formula I, which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

    摘要翻译： 本发明涉及式I的烷氧基四氢 - 吡啶并嘧啶化合物，其可用作治疗与磷酸二酯酶10（PDE10）相关的中枢神经系统疾病的治疗剂。 本发明还涉及这些化合物用于治疗神经和精神疾病如精神分裂症，精神病或亨廷顿病以及与纹状体功能减退或基底神经节功能障碍相关的疾病的用途。

    2,5-disubstituted morpholine orexin receptor antagonists
    9.
    发明授权
    2,5-disubstituted morpholine orexin receptor antagonists 有权
    2,5-二取代吗啉食欲肽受体拮抗剂

    公开(公告)号：US08466281B2

    公开(公告)日：2013-06-18

    申请号：US13124884

    申请日：2009-10-15

    申请人： Paul J. Coleman ,  Christopher D. Cox ,  Broc Flores ,  John D. Schreier

    发明人： Paul J. Coleman ,  Christopher D. Cox ,  Broc Flores ,  John D. Schreier

    IPC分类号： C07D265/30 ,  A61K31/535

    CPC分类号： A61K31/445 ,  C07D265/28 ,  C07D413/10 ,  C07D413/14

    摘要： The present invention is directed to 2,5-disubstituted morpholine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的2,5-二取代的吗啉酰胺化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。